DNPH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description 2'-deoxynucleoside 5'-phosphate N-hydrolase 1|This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10591)
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Genes

341 genes differentially expressed following the DNPH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ATP13A5 ATPase type 13A5 2.93831
RRAD Ras-related associated with diabetes 2.93831
SIRPB1 signal-regulatory protein beta 1 2.93831
TMEM191B transmembrane protein 191B 2.93831
CCL5 chemokine (C-C motif) ligand 5 2.93831
XCL1 chemokine (C motif) ligand 1 2.93831
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.93831
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.93831
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.93831
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.93831
TAS2R8 taste receptor, type 2, member 8 2.93831
KRT24 keratin 24, type I 2.93831
HORMAD2 HORMA domain containing 2 2.93831
TM4SF1 transmembrane 4 L six family member 1 2.93831
RGS9BP regulator of G protein signaling 9 binding protein 2.93831
FPR2 formyl peptide receptor 2 2.93831
MYBPHL myosin binding protein H-like 2.93831
RASL10A RAS-like, family 10, member A 2.93831
MAP3K7CL MAP3K7 C-terminal like 2.93831
NPAP1 nuclear pore associated protein 1 2.93831
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.93831
KNG1 kininogen 1 2.93831
CABP4 calcium binding protein 4 2.93831
TMEM176A transmembrane protein 176A 2.93831
CA6 carbonic anhydrase VI 2.93831
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.93831
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.93831
RXRG retinoid X receptor, gamma 2.93831
SERTM1 serine-rich and transmembrane domain containing 1 2.93831
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.93831
ZNF804A zinc finger protein 804A 2.93831
EMCN endomucin 2.93831
ERAP2 endoplasmic reticulum aminopeptidase 2 2.93831
CCDC87 coiled-coil domain containing 87 2.93831
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.93831
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.93831
OVCH1 ovochymase 1 2.93831
JCHAIN joining chain of multimeric IgA and IgM 2.93831
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.93831
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.93831
C3ORF22 chromosome 3 open reading frame 22 2.93831
TDRD6 tudor domain containing 6 2.93831
C9ORF152 chromosome 9 open reading frame 152 2.93831
GMFG glia maturation factor, gamma 2.93831
SPP2 secreted phosphoprotein 2, 24kDa 2.93831
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.93831
PSCA prostate stem cell antigen 2.93831
FABP12 fatty acid binding protein 12 2.93831
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.93831
RHOJ ras homolog family member J 2.93831
IZUMO4 IZUMO family member 4 2.93831
LRTM3 leucine rich repeat transmembrane protein 3 2.93831
GBP1 guanylate binding protein 1, interferon-inducible 2.93831
RAG2 recombination activating gene 2 2.93831
RHCG Rh family, C glycoprotein 2.93831
STX11 syntaxin 11 2.93831
FIMP1 fertilization-influencing membrane protein 1 2.93831
C20ORF202 chromosome 20 open reading frame 202 2.93831
RDH8 retinol dehydrogenase 8 (all-trans) 2.93831
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.93831
HNF1B HNF1 homeobox B 2.93831
SOAT2 sterol O-acyltransferase 2 2.93831
PHF24 PHD finger protein 24 2.93831
HTD2 hydroxyacyl-thioester dehydratase type 2 2.93831
DEPP1 DEPP autophagy regulator 1 2.93831
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.93831
SPEGNB SPEG neighbor 2.93831
FAM240A family with sequence similarity 240 member A 2.93831
C20ORF204 chromosome 20 open reading frame 204 2.93831
GSTT4 glutathione S-transferase theta 4 2.93831
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.93831
VXN vexin 2.93831
CFAP141 cilia and flagella associated protein 141 2.93831
AJM1 apical junction component 1 homolog 2.93831
MARCHF10 membrane associated ring-CH-type finger 10 2.93831
LRRC72 leucine rich repeat containing 72 2.93831
PLEK2 pleckstrin 2 2.93831
C10ORF67 chromosome 10 open reading frame 67 2.93831
SLC22A25 solute carrier family 22, member 25 2.93831
OLAH oleoyl-ACP hydrolase 2.93831
MAL mal, T-cell differentiation protein 2.93831
FAM43B family with sequence similarity 43, member B 2.93831
PTGDR2 prostaglandin D2 receptor 2 2.93831
PCDHB11 protocadherin beta 11 2.93831
GGT6 gamma-glutamyltransferase 6 2.93831
SLFN14 schlafen family member 14 2.93831
ACTL8 actin-like 8 2.93831
ZIC4 Zic family member 4 2.93831
RNF113B ring finger protein 113B 2.93831
C1QL4 complement component 1, q subcomponent-like 4 2.93831
ARHGAP15 Rho GTPase activating protein 15 2.93831
VCX3A variable charge, X-linked 3A 2.93831
ADIG adipogenin 2.93831
C7 complement component 7 2.93831
SAA1 serum amyloid A1 2.93831
UTS2 urotensin 2 2.93831
SBSN suprabasin 2.93831
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.93831
PRR18 proline rich 18 2.93831
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.93831
LIPJ lipase, family member J 2.93831
GALP galanin-like peptide 2.93831
A3GALT2 alpha 1,3-galactosyltransferase 2 2.93831
SPATA3 spermatogenesis associated 3 2.93831
CLEC4G C-type lectin domain family 4, member G 2.93831
IL36R interleukin 36 receptor 2.93831
MAB21L3 mab-21-like 3 (C. elegans) 2.93831
C22ORF42 chromosome 22 open reading frame 42 2.93831
BAHCC1 BAH domain and coiled-coil containing 1 2.93831
EVPLL envoplakin-like 2.93831
IFITM5 interferon induced transmembrane protein 5 2.93831
VWA3A von Willebrand factor A domain containing 3A 2.93831
CDK20 cyclin-dependent kinase 20 2.93831
PLET1 placenta expressed transcript 1 2.93831
WFDC6 WAP four-disulfide core domain 6 2.93831
TBC1D10C TBC1 domain family, member 10C 2.93831
HAMP hepcidin antimicrobial peptide 2.93831
C18ORF63 chromosome 18 open reading frame 63 2.93831
CDC20B cell division cycle 20B 2.93831
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.93831
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.93831
THTPA thiamine triphosphatase 2.93831
HHLA2 HERV-H LTR-associating 2 2.93831
CXCR2 chemokine (C-X-C motif) receptor 2 2.93831
CYSLTR1 cysteinyl leukotriene receptor 1 2.93831
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.93831
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.93831
KLK15 kallikrein-related peptidase 15 2.93831
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.93831
IGIP IgA-inducing protein 2.93831
CPN2 carboxypeptidase N, polypeptide 2 2.93831
ADAM11 ADAM metallopeptidase domain 11 2.93831
NPY2R neuropeptide Y receptor Y2 2.93831
ZNF831 zinc finger protein 831 2.93831
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.93831
BHLHA15 basic helix-loop-helix family, member a15 2.93831
LRRC26 leucine rich repeat containing 26 2.93831
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.93831
RGS4 regulator of G-protein signaling 4 2.93831
FUOM fucose mutarotase 2.93831
PENK proenkephalin 2.93831
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.93831
SIRPD signal-regulatory protein delta 2.93831
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.93831
UTS2B urotensin 2B 2.93831
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.93831
C8G complement component 8, gamma polypeptide 2.93831
EXT2 exostosin glycosyltransferase 2 2.93831
CRYBA4 crystallin, beta A4 2.93831
DMRT2 doublesex and mab-3 related transcription factor 2 2.93831
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.93831
SIDT1 SID1 transmembrane family, member 1 2.93831
FBXO39 F-box protein 39 2.93831
IFNE interferon, epsilon 2.93831
ABRA actin binding Rho activating protein 2.93831
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.93831
MMP10 matrix metallopeptidase 10 2.93831
AQP1 aquaporin 1 (Colton blood group) 2.93831
SCN3A sodium channel, voltage gated, type III alpha subunit 2.93831
MTG2 mitochondrial ribosome-associated GTPase 2 2.93831
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.93831
C5AR2 complement component 5a receptor 2 2.93831
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 2.93831
SLITRK1 SLIT and NTRK-like family, member 1 2.93831
CBR3 carbonyl reductase 3 2.93831
ST18 suppression of tumorigenicity 18, zinc finger 2.93831
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.93831
XCR1 chemokine (C motif) receptor 1 2.93831
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.93831
MAGEA10 melanoma antigen family A10 2.93831
TUBAL3 tubulin, alpha-like 3 2.93831
APOL1 apolipoprotein L, 1 2.93831
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.93831
VWC2L von Willebrand factor C domain containing protein 2-like 2.93831
NLRP11 NLR family, pyrin domain containing 11 2.93831
LOXL4 lysyl oxidase-like 4 2.93831
GLB1L galactosidase, beta 1-like 2.93831
TBC1D26 TBC1 domain family, member 26 2.93831
ICAM5 intercellular adhesion molecule 5, telencephalin 2.93831
ZNF474 zinc finger protein 474 2.93831
KRT15 keratin 15, type I 2.93831
CPO carboxypeptidase O 2.93831
NEUROD4 neuronal differentiation 4 2.93831
MNX1 motor neuron and pancreas homeobox 1 2.93831
CALML6 calmodulin-like 6 2.93831
DBX2 developing brain homeobox 2 2.93831
PTGDR prostaglandin D2 receptor (DP) 2.93831
TRAP1 TNF receptor-associated protein 1 2.8788
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.82461
KCTD21 potassium channel tetramerization domain containing 21 2.82461
TFF3 trefoil factor 3 (intestinal) 2.82461
PRSS53 protease, serine, 53 2.82461
CFAP90 cilia and flagella associated protein 90 2.82461
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.78147
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 2.77617
DIAPH3 diaphanous-related formin 3 2.68678
TOR3A torsin family 3, member A 2.68175
GLTP glycolipid transfer protein 2.65685
ZNF239 zinc finger protein 239 2.59769
MYO5B myosin VB 2.56325
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 2.55754
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.55754
LMX1B LIM homeobox transcription factor 1, beta 2.46919
ILF2 interleukin enhancer binding factor 2 2.44556
RAB36 RAB36, member RAS oncogene family 2.4357
USP50 ubiquitin specific peptidase 50 2.4357
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 2.41739
BSDC1 BSD domain containing 1 2.40224
SLC2A4RG SLC2A4 regulator 2.39042
AXL AXL receptor tyrosine kinase 2.32021
ADCK1 aarF domain containing kinase 1 2.31909
MYO18B myosin XVIIIB 2.31901
ARRDC4 arrestin domain containing 4 2.31901
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.28896
IDI2 isopentenyl-diphosphate delta isomerase 2 2.26896
GPATCH4 G patch domain containing 4 2.22865
TMEM192 transmembrane protein 192 2.21447
RRAGC Ras-related GTP binding C 2.21132
TNRC6A trinucleotide repeat containing 6A 2.21132
TATDN3 TatD DNase domain containing 3 2.17114
D2HGDH D-2-hydroxyglutarate dehydrogenase 2.12891
FOXL2NB FOXL2 neighbor 2.1274
PCP4 Purkinje cell protein 4 2.10825
ANKRD13B ankyrin repeat domain 13B 2.09095
TNIK TRAF2 and NCK interacting kinase 2.07903
TTLL11 tubulin tyrosine ligase-like family member 11 2.07903
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 2.07801
MXRA8 matrix-remodelling associated 8 2.06869
DZIP1 DAZ interacting zinc finger protein 1 2.06534
BLTP2 bridge-like lipid transfer protein family member 2 2.05754
TPD52L2 tumor protein D52-like 2 2.04563
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.03709
SPRYD4 SPRY domain containing 4 2.02886
STK16 serine/threonine kinase 16 2.02886
RANBP3 RAN binding protein 3 2.00648
PGBD2 piggyBac transposable element derived 2 2.0042
HSBP1L1 heat shock factor binding protein 1-like 1 2.00323

decreased expression

Symbol Name Standardized Value
CD34 CD34 molecule -2.93831
GLRA3 glycine receptor, alpha 3 -2.93831
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -2.93831
CHRND cholinergic receptor, nicotinic, delta (muscle) -2.93831
OVGP1 oviductal glycoprotein 1, 120kDa -2.93831
CPED1 cadherin-like and PC-esterase domain containing 1 -2.93831
ACOT1 acyl-CoA thioesterase 1 -2.93831
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.93831
SCRG1 stimulator of chondrogenesis 1 -2.93831
TMEM82 transmembrane protein 82 -2.93831
NUTM2A NUT family member 2A -2.93831
VPREB3 pre-B lymphocyte 3 -2.93831
IRX4 iroquois homeobox 4 -2.93831
TMEM87A transmembrane protein 87A -2.93831
SNX13 sorting nexin 13 -2.93831
ACRBP acrosin binding protein -2.93831
LOC102724877 uncharacterized LOC102724877 -2.93831
FGF16 fibroblast growth factor 16 -2.93831
MMP3 matrix metallopeptidase 3 -2.93831
KIZ kizuna centrosomal protein -2.93831
SERINC4 serine incorporator 4 -2.93831
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.93831
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.93831
PRDM6 PR domain containing 6 -2.93831
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.93831
SCN1B sodium channel, voltage gated, type I beta subunit -2.93831
PRELID3B PRELI domain containing 3B -2.93831
SLC49A3 solute carrier family 49 member 3 -2.93831
LRRC8C-DT LRRC8C divergent transcript -2.93831
C5 complement component 5 -2.93831
ZC3H11C zinc finger CCCH-type containing 11C -2.93831
CD53 CD53 molecule -2.93831
TRIM50 tripartite motif containing 50 -2.93831
ZSWIM1 zinc finger, SWIM-type containing 1 -2.93831
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.93831
SYNPO synaptopodin -2.93831
PCDH12 protocadherin 12 -2.93831
SSC5D scavenger receptor cysteine rich family, 5 domains -2.93831
MIGA1 mitoguardin 1 -2.92995
ZDHHC7 zinc finger, DHHC-type containing 7 -2.92948
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.91144
PCGF1 polycomb group ring finger 1 -2.91144
FAM133A family with sequence similarity 133, member A -2.83601
PTCH2 patched 2 -2.7705
GCHFR GTP cyclohydrolase I feedback regulator -2.75441
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.6882
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.61321
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.60668
MED17 mediator complex subunit 17 -2.59769
KIF21B kinesin family member 21B -2.59769
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.56049
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.54619
RAB10 RAB10, member RAS oncogene family -2.51544
FZD7 frizzled class receptor 7 -2.48426
CRYGD crystallin, gamma D -2.4632
MIX23 mitochondrial matrix import factor 23 -2.46293
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.45493
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.41739
IRF4 interferon regulatory factor 4 -2.40981
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.40981
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.40981
SPMIP5 sperm microtubule inner protein 5 -2.3869
SPAG9 sperm associated antigen 9 -2.35417
GRAMD1C GRAM domain containing 1C -2.33735
MRPL18 mitochondrial ribosomal protein L18 -2.31901
ZNF500 zinc finger protein 500 -2.31901
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.30917
RAD51AP1 RAD51 associated protein 1 -2.29233
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.29233
ITLN2 intelectin 2 -2.29233
GLB1L2 galactosidase, beta 1-like 2 -2.27316
REST RE1-silencing transcription factor -2.27295
ACBD7 acyl-CoA binding domain containing 7 -2.2455
RNF6 ring finger protein (C3H2C3 type) 6 -2.23591
FAM117B family with sequence similarity 117, member B -2.23502
GCDH glutaryl-CoA dehydrogenase -2.23043
PAQR3 progestin and adipoQ receptor family member III -2.22767
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.17192
TAOK1 TAO kinase 1 -2.1436
EMC9 ER membrane protein complex subunit 9 -2.12891
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.12797
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.10067
NUTM2E NUT family member 2E -2.09891
HDAC5 histone deacetylase 5 -2.08901
HEXIM2 hexamethylene bis-acetamide inducible 2 -2.08901
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.08772
RIOK2 RIO kinase 2 -2.08411
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.07943
ZCCHC2 zinc finger, CCHC domain containing 2 -2.07903
MECOM MDS1 and EVI1 complex locus -2.05823
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.05003
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) -2.0429
C19ORF33 chromosome 19 open reading frame 33 -2.0429
PRDM15 PR domain containing 15 -2.03709
RAB29 RAB29, member RAS oncogene family -2.02886
DOHH deoxyhypusine hydroxylase/monooxygenase -2.02886
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.0248
CANT1 calcium activated nucleotidase 1 -2.01417
C19ORF38 chromosome 19 open reading frame 38 -2.01064
NCOA5 nuclear receptor coactivator 5 -2.01064
ESRRB estrogen-related receptor beta -2.00842
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.00652
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.00323
IRS2 insulin receptor substrate 2 -2.00279