DOCK4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description dedicator of cytokinesis 4|This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9732)
External Link http://www.ncbi.nlm.nih.gov/gene/9732
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Genes

107 interacting proteins for DOCK4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP12 Rho GTPase activating protein 12
ARHGAP20 Rho GTPase activating protein 20
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BCR breakpoint cluster region
C11ORF84 chromosome 11 open reading frame 84
C1ORF27 chromosome 1 open reading frame 27
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD2AP CD2-associated protein
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CTTN cortactin
DIAPH1 diaphanous-related formin 1
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK5 dedicator of cytokinesis 5
EGFR epidermal growth factor receptor
EIF4A3 eukaryotic translation initiation factor 4A3
ELMO2 engulfment and cell motility 2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERRFI1 ERBB receptor feedback inhibitor 1
FASLG Fas ligand (TNF superfamily, member 6)
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FGD6 FYVE, RhoGEF and PH domain containing 6
FRS2 fibroblast growth factor receptor substrate 2
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAREM GRB2 associated, regulator of MAPK1
GAREML GRB2 associated, regulator of MAPK1-like
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRB2 growth factor receptor-bound protein 2
GRK5 G protein-coupled receptor kinase 5
HACD3 3-hydroxyacyl-CoA dehydratase 3
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNRNPL heterogeneous nuclear ribonucleoprotein L
HUNK hormonally up-regulated Neu-associated kinase
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIRREL kin of IRRE like (Drosophila)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MYCBP MYC binding protein
NCKAP1 NCK-associated protein 1
NISCH nischarin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRJ protein tyrosine phosphatase, receptor type, J
RADIL Ras association and DIL domains
RBBP6 retinoblastoma binding protein 6
RNF115 ring finger protein 115
SH2D5 SH2 domain containing 5
SH3PXD2A SH3 and PX domains 2A
SH3PXD2B SH3 and PX domains 2B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRPA signal-regulatory protein alpha
SLAIN2 SLAIN motif family, member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNX18 sorting nexin 18
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STAMBP STAM binding protein
SYNJ1 synaptojanin 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEC tec protein tyrosine kinase
TSG101 tumor susceptibility 101
TTYH2 tweety family member 2
UBC ubiquitin C
VAV3 vav 3 guanine nucleotide exchange factor
WASL Wiskott-Aldrich syndrome-like
WDR44 WD repeat domain 44
WDR6 WD repeat domain 6
WDR77 WD repeat domain 77
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta