DORSOMORPHIN Gene Set

Dataset	DGIdb Drug Targets 2026
Category	physical interactions
Type	drug
Description	A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. (Chemical Entities of Biological Interest Ontology, CHEBI_78510)
External Link	https://dgidb.org/results?searchType=drug&searchTerms=DORSOMORPHIN
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Genes

9 interacting proteins for the DORSOMORPHIN drug from theDGIdb Drug Targets 2026 dataset.

Symbol	Name	Standardized Value
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.84019
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.490111
EPHA2	EPH receptor A2	0.235253
SRC	SRC proto-oncogene, non-receptor tyrosine kinase	0.0773859
LCK	LCK proto-oncogene, Src family tyrosine kinase	0.0735167
FLT1	fms-related tyrosine kinase 1	0.0554843
KDR	kinase insert domain receptor	0.0289721
YES1	YES proto-oncogene 1, Src family tyrosine kinase	0.0276119
FLT3	fms-related tyrosine kinase 3	0.0262559