DROSHA Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description drosha, ribonuclease type III|Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 29102)
External Link http://www.ncbi.nlm.nih.gov/gene/29102
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Genes

456 target genes of the DROSHA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
AACS acetoacetyl-CoA synthetase
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADAM12 ADAM metallopeptidase domain 12
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADCK3 aarF domain containing kinase 3
ADCY1 adenylate cyclase 1 (brain)
ADGRB1 adhesion G protein-coupled receptor B1
ADGRD1 adhesion G protein-coupled receptor D1
ADORA2B adenosine A2b receptor
AFAP1 actin filament associated protein 1
AFF3 AF4/FMR2 family, member 3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGBL4 ATP/GTP binding protein-like 4
AGO2 argonaute RISC catalytic component 2
AGTPBP1 ATP/GTP binding protein 1
AHRR aryl-hydrocarbon receptor repressor
AK4 adenylate kinase 4
AKNA AT-hook transcription factor
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX5 arachidonate 5-lipoxygenase
ALX4 ALX homeobox 4
AMOTL1 angiomotin like 1
ANKMY1 ankyrin repeat and MYND domain containing 1
ANKRD24 ankyrin repeat domain 24
ANO1 anoctamin 1, calcium activated chloride channel
ANO4 anoctamin 4
ARHGAP22 Rho GTPase activating protein 22
ARHGAP6 Rho GTPase activating protein 6
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMC2 armadillo repeat containing 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASS1 argininosuccinate synthase 1
ATAD5 ATPase family, AAA domain containing 5
ATCAY ataxia, cerebellar, Cayman type
ATF6 activating transcription factor 6
ATG4C autophagy related 4C, cysteine peptidase
ATN1 atrophin 1
ATP10B ATPase, class V, type 10B
ATXN1 ataxin 1
ATXN7L1 ataxin 7-like 1
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
BCAM basal cell adhesion molecule (Lutheran blood group)
BCAS3 breast carcinoma amplified sequence 3
BCL9 B-cell CLL/lymphoma 9
BPI bactericidal/permeability-increasing protein
BPIFB4 BPI fold containing family B, member 4
C10ORF11 chromosome 10 open reading frame 11
C11ORF24 chromosome 11 open reading frame 24
C12ORF4 chromosome 12 open reading frame 4
C12ORF57 chromosome 12 open reading frame 57
C17ORF70 chromosome 17 open reading frame 70
C1ORF228 chromosome 1 open reading frame 228
C1QB complement component 1, q subcomponent, B chain
C21ORF58 chromosome 21 open reading frame 58
C22ORF34 chromosome 22 open reading frame 34
CA10 carbonic anhydrase X
CABP1 calcium binding protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMTA1 calmodulin binding transcription activator 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CARD6 caspase recruitment domain family, member 6
CATSPERD catsper channel auxiliary subunit delta
CCBL2 cysteine conjugate-beta lyase 2
CCDC114 coiled-coil domain containing 114
CCDC57 coiled-coil domain containing 57
CD46 CD46 molecule, complement regulatory protein
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CELF2 CUGBP, Elav-like family member 2
CELF4 CUGBP, Elav-like family member 4
CELF5 CUGBP, Elav-like family member 5
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CEP170B centrosomal protein 170B
CERS4 ceramide synthase 4
CHD5 chromodomain helicase DNA binding protein 5
CHD6 chromodomain helicase DNA binding protein 6
CLCA4 chloride channel accessory 4
CLEC17A C-type lectin domain family 17, member A
CLTC clathrin, heavy chain (Hc)
CNTLN centlein, centrosomal protein
CNTNAP2 contactin associated protein-like 2
CNTNAP5 contactin associated protein-like 5
COL13A1 collagen, type XIII, alpha 1
COL15A1 collagen, type XV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL22A1 collagen, type XXII, alpha 1
COL23A1 collagen, type XXIII, alpha 1
COL26A1 collagen, type XXVI, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A2 collagen, type VI, alpha 2
COPA coatomer protein complex, subunit alpha
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8
CPM carboxypeptidase M
CPNE9 copine family member IX
CPT1C carnitine palmitoyltransferase 1C
CREM cAMP responsive element modulator
CRHR2 corticotropin releasing hormone receptor 2
CTNND2 catenin (cadherin-associated protein), delta 2
CUX2 cut-like homeobox 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DCLK1 doublecortin-like kinase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEFB119 defensin, beta 119
DENND5B DENN/MADD domain containing 5B
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DISC1 disrupted in schizophrenia 1
DLEC1 deleted in lung and esophageal cancer 1
DLG2 discs, large homolog 2 (Drosophila)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNAH9 dynein, axonemal, heavy chain 9
DNASE1L1 deoxyribonuclease I-like 1
DOCK6 dedicator of cytokinesis 6
DPH7 diphthamide biosynthesis 7
DSCR4 Down syndrome critical region 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DYSF dysferlin
E2F6 E2F transcription factor 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFCAB1 EF-hand calcium binding domain 1
EIF3A eukaryotic translation initiation factor 3, subunit A
ELL elongation factor RNA polymerase II
ELN elastin
EMX2 empty spiracles homeobox 2
EPHA10 EPH receptor A10
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ERC2 ELKS/RAB6-interacting/CAST family member 2
EVC2 Ellis van Creveld syndrome 2
EXOC4 exocyst complex component 4
FAM101A family with sequence similarity 101, member A
FAM135B family with sequence similarity 135, member B
FAM157A family with sequence similarity 157, member A
FAM168A family with sequence similarity 168, member A
FAM169B family with sequence similarity 169, member B
FAM188B family with sequence similarity 188, member B
FAM189A1 family with sequence similarity 189, member A1
FAM24A family with sequence similarity 24, member A
FAM3D family with sequence similarity 3, member D
FAT1 FAT atypical cadherin 1
FAT3 FAT atypical cadherin 3
FBLN1 fibulin 1
FBLN2 fibulin 2
FBN3 fibrillin 3
FBRSL1 fibrosin-like 1
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FER fer (fps/fes related) tyrosine kinase
FGD3 FYVE, RhoGEF and PH domain containing 3
FGF3 fibroblast growth factor 3
FIG4 FIG4 phosphoinositide 5-phosphatase
FLRT1 fibronectin leucine rich transmembrane protein 1
FLT4 fms-related tyrosine kinase 4
FRMPD2 FERM and PDZ domain containing 2
FRY furry homolog (Drosophila)
FYB FYN binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GAS6 growth arrest-specific 6
GAS7 growth arrest-specific 7
GHRHR growth hormone releasing hormone receptor
GLIPR2 GLI pathogenesis-related 2
GLRA1 glycine receptor, alpha 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMDS GDP-mannose 4,6-dehydratase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GOLGA1 golgin A1
GOLM1 golgi membrane protein 1
GPR173 G protein-coupled receptor 173
GPR68 G protein-coupled receptor 68
GRAMD4 GRAM domain containing 4
GRB10 growth factor receptor-bound protein 10
GRIK3 glutamate receptor, ionotropic, kainate 3
HHAT hedgehog acyltransferase
HIF3A hypoxia inducible factor 3, alpha subunit
HIST1H1C histone cluster 1, H1c
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNF1A HNF1 homeobox A
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like
HSF2BP heat shock transcription factor 2 binding protein
HTRA3 HtrA serine peptidase 3
ICA1 islet cell autoantigen 1, 69kDa
IER2 immediate early response 2
IGHE immunoglobulin heavy constant epsilon
IGSF21 immunoglobin superfamily, member 21
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL2RA interleukin 2 receptor, alpha
INMT indolethylamine N-methyltransferase
INSR insulin receptor
IPCEF1 interaction protein for cytohesin exchange factors 1
ITGA11 integrin, alpha 11
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
JAKMIP1 janus kinase and microtubule interacting protein 1
JAKMIP3 Janus kinase and microtubule interacting protein 3
JPH2 junctophilin 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM4B lysine (K)-specific demethylase 4B
KIAA0319 KIAA0319
KIAA1024 KIAA1024
KIAA1549L KIAA1549-like
KIF17 kinesin family member 17
KLHL26 kelch-like family member 26
KLK13 kallikrein-related peptidase 13
KLK15 kallikrein-related peptidase 15
KLK5 kallikrein-related peptidase 5
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1
KRT77 keratin 77, type II
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LGI4 leucine-rich repeat LGI family, member 4
LINC00111 long intergenic non-protein coding RNA 111
LMNB2 lamin B2
LMX1B LIM homeobox transcription factor 1, beta
LOXHD1 lipoxygenase homology domains 1
LRRC2 leucine rich repeat containing 2
LRRC27 leucine rich repeat containing 27
LRRC74A leucine rich repeat containing 74A
LRRK1 leucine-rich repeat kinase 1
MACROD1 MACRO domain containing 1
MAG myelin associated glycoprotein
MBP myelin basic protein
MCF2L MCF.2 cell line derived transforming sequence-like
MGLL monoglyceride lipase
MIER1 mesoderm induction early response 1, transcriptional regulator
MLPH melanophilin
MLXIPL MLX interacting protein-like
MOB3B MOB kinase activator 3B
MPZL1 myelin protein zero-like 1
MSH4 mutS homolog 4
MUC16 mucin 16, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MYBPC2 myosin binding protein C, fast type
MYCBPAP MYCBP associated protein
MYH14 myosin, heavy chain 14, non-muscle
MYO18A myosin XVIIIA
MYO18B myosin XVIIIB
MYO1F myosin IF
MYO1H myosin IH
MYO7A myosin VIIA
MYO7B myosin VIIB
MYO9B myosin IXB
MYT1L myelin transcription factor 1-like
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEGR1 neuronal growth regulator 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NIPAL2 NIPA-like domain containing 2
NLK nemo-like kinase
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS4 neuronal PAS domain protein 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NSUN6 NOP2/Sun domain family, member 6
NUCB1 nucleobindin 1
NUP88 nucleoporin 88kDa
NWD1 NACHT and WD repeat domain containing 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ODF3L2 outer dense fiber of sperm tails 3-like 2
OSBPL5 oxysterol binding protein-like 5
OTOF otoferlin
OTUD7A OTU deubiquitinase 7A
OTUD7B OTU deubiquitinase 7B
OXCT1 3-oxoacid CoA transferase 1
PALLD palladin, cytoskeletal associated protein
PARVG parvin, gamma
PAX4 paired box 4
PBX1 pre-B-cell leukemia homeobox 1
PCBP2 poly(rC) binding protein 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE9A phosphodiesterase 9A
PDZK1IP1 PDZK1 interacting protein 1
PEBP4 phosphatidylethanolamine-binding protein 4
PEPD peptidase D
PEX12 peroxisomal biogenesis factor 12
PEX5L peroxisomal biogenesis factor 5-like
PHACTR1 phosphatase and actin regulator 1
PHACTR3 phosphatase and actin regulator 3
PHF2 PHD finger protein 2
PITPNM3 PITPNM family member 3
PLBD2 phospholipase B domain containing 2
PLVAP plasmalemma vesicle associated protein
PLXNA4 plexin A4
PNPLA7 patatin-like phospholipase domain containing 7
PPP6R2 protein phosphatase 6, regulatory subunit 2
PQLC1 PQ loop repeat containing 1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRIMA1 proline rich membrane anchor 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRLR prolactin receptor
PRR12 proline rich 12
PSAT1 phosphoserine aminotransferase 1
PSD2 pleckstrin and Sec7 domain containing 2
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXDN peroxidasin
RAB8A RAB8A, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RANBP9 RAN binding protein 9
RARB retinoic acid receptor, beta
RASA3 RAS p21 protein activator 3
RELN reelin
RET ret proto-oncogene
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RIMS4 regulating synaptic membrane exocytosis 4
RIN2 Ras and Rab interactor 2
RIN3 Ras and Rab interactor 3
RNF144A ring finger protein 144A
RNF213 ring finger protein 213
RNFT2 ring finger protein, transmembrane 2
RNU11 RNA, U11 small nuclear
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPL10 ribosomal protein L10
RPL27A ribosomal protein L27a
RPL41 ribosomal protein L41
RPS6 ribosomal protein S6
RTBDN retbindin
SAE1 SUMO1 activating enzyme subunit 1
SAMD5 sterile alpha motif domain containing 5
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDK1 sidekick cell adhesion molecule 1
SEC14L3 SEC14-like 3 (S. cerevisiae)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERINC2 serine incorporator 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFMBT2 Scm-like with four mbt domains 2
SFT2D2 SFT2 domain containing 2
SH3PXD2A SH3 and PX domains 2A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHISA6 shisa family member 6
SHROOM2 shroom family member 2
SIN3B SIN3 transcription regulator family member B
SLC10A7 solute carrier family 10, member 7
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SLC39A11 solute carrier family 39, member 11
SLC44A3 solute carrier family 44, member 3
SLC44A5 solute carrier family 44, member 5
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLFN12L schlafen family member 12-like
SMOC1 SPARC related modular calcium binding 1
SMOC2 SPARC related modular calcium binding 2
SNORD7 small nucleolar RNA, C/D box 7
SORCS3 sortilin-related VPS10 domain containing receptor 3
SPAG9 sperm associated antigen 9
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPEF2 sperm flagellar 2
SPTBN4 spectrin, beta, non-erythrocytic 4
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRRM4 serine/arginine repetitive matrix 4
SSH2 slingshot protein phosphatase 2
SSPO SCO-spondin
SST somatostatin
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STAB2 stabilin 2
STAP2 signal transducing adaptor family member 2
STK10 serine/threonine kinase 10
STKLD1 serine/threonine kinase-like domain containing 1
STX8 syntaxin 8
SUSD4 sushi domain containing 4
SV2C synaptic vesicle glycoprotein 2C
SYN3 synapsin III
SYNJ2 synaptojanin 2
SYT2 synaptotagmin II
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TBCD tubulin folding cofactor D
TBX5 T-box 5
TEKT1 tektin 1
TERT telomerase reverse transcriptase
TEX14 testis expressed 14
TG thyroglobulin
THBS2 thrombospondin 2
THOP1 thimet oligopeptidase 1
TMEM108 transmembrane protein 108
TMEM132B transmembrane protein 132B
TMEM132D transmembrane protein 132D
TMEM211 transmembrane protein 211
TMEM255B transmembrane protein 255B
TMEM56 transmembrane protein 56
TMEM72 transmembrane protein 72
TMPRSS6 transmembrane protease, serine 6
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNXB tenascin XB
TP73 tumor protein p73
TRAPPC9 trafficking protein particle complex 9
TRIM37 tripartite motif containing 37
TRIO trio Rho guanine nucleotide exchange factor
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSHZ2 teashirt zinc finger homeobox 2
TSHZ3 teashirt zinc finger homeobox 3
TSNARE1 t-SNARE domain containing 1
TSSC1 tumor suppressing subtransferable candidate 1
TTC7A tetratricopeptide repeat domain 7A
TTLL3 tubulin tyrosine ligase-like family member 3
TUBGCP6 tubulin, gamma complex associated protein 6
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UMODL1 uromodulin-like 1
UNC13A unc-13 homolog A (C. elegans)
UNC5A unc-5 homolog A (C. elegans)
USH2A Usher syndrome 2A (autosomal recessive, mild)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VEZF1 vascular endothelial zinc finger 1
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2
VRK3 vaccinia related kinase 3
VSTM2B V-set and transmembrane domain containing 2B
VTRNA1-3 vault RNA 1-3
WAS Wiskott-Aldrich syndrome
WISP1 WNT1 inducible signaling pathway protein 1
WNT3A wingless-type MMTV integration site family, member 3A
WNT7B wingless-type MMTV integration site family, member 7B
WSCD1 WSC domain containing 1
WSCD2 WSC domain containing 2
XKR7 XK, Kell blood group complex subunit-related family, member 7
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZAN zonadhesin (gene/pseudogene)
ZC3H10 zinc finger CCCH-type containing 10
ZFP3 ZFP3 zinc finger protein
ZFYVE28 zinc finger, FYVE domain containing 28
ZNF17 zinc finger protein 17
ZNF454 zinc finger protein 454
ZZZ3 zinc finger, ZZ-type containing 3