DROSHA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description drosha, ribonuclease type III|Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 29102)
External Link http://www.ncbi.nlm.nih.gov/gene/29102
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153 interacting proteins for DROSHA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ALMS1 Alstrom syndrome protein 1
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF7 activating transcription factor 7
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
C1ORF35 chromosome 1 open reading frame 35
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CARM1 coactivator-associated arginine methyltransferase 1
CLASRP CLK4-associating serine/arginine rich protein
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CSMD1 CUB and Sushi multiple domains 1
CUL3 cullin 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGCR8 DGCR8 microprocessor complex subunit
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DIDO1 death inducer-obliterator 1
DNAH9 dynein, axonemal, heavy chain 9
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHB6 EPH receptor B6
ERCC5 excision repair cross-complementation group 5
FUS FUS RNA binding protein
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HNF1A HNF1 homeobox A
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSF4 heat shock transcription factor 4
IDI2 isopentenyl-diphosphate delta isomerase 2
KDM2A lysine (K)-specific demethylase 2A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KHSRP KH-type splicing regulatory protein
KIF13B kinesin family member 13B
KLHL12 kelch-like family member 12
KMT2B lysine (K)-specific methyltransferase 2B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR2 lysophosphatidic acid receptor 2
LPAR4 lysophosphatidic acid receptor 4
LSM1 LSM1, U6 small nuclear RNA associated
LUC7L LUC7-like (S. cerevisiae)
LUC7L2 LUC7-like 2 (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED23 mediator complex subunit 23
MEN1 multiple endocrine neoplasia I
MTMR6 myotubularin related protein 6
NCK1 NCK adaptor protein 1
NCOR2 nuclear receptor corepressor 2
NKRF NFKB repressing factor
NOP2 NOP2 nucleolar protein
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
OLA1 Obg-like ATPase 1
OSBPL1A oxysterol binding protein-like 1A
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PANX3 pannexin 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PCBP1 poly(rC) binding protein 1
PCDH9 protocadherin 9
PDCD6 programmed cell death 6
PKP2 plakophilin 2
PNN pinin, desmosome associated protein
POU2F3 POU class 2 homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRPF4B pre-mRNA processing factor 4B
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
RBBP6 retinoblastoma binding protein 6
RBM14 RNA binding motif protein 14
RBM39 RNA binding motif protein 39
RBM8A RNA binding motif protein 8A
SAE1 SUMO1 activating enzyme subunit 1
SENP7 SUMO1/sentrin specific peptidase 7
SIN3A SIN3 transcription regulator family member A
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMO smoothened, frizzled class receptor
SNIP1 Smad nuclear interacting protein 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SON SON DNA binding protein
SP1 Sp1 transcription factor
SPEN spen family transcriptional repressor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPK1 SRSF protein kinase 1
SRPK2 SRSF protein kinase 2
SRPK3 SRSF protein kinase 3
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SRSF2 serine/arginine-rich splicing factor 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SRSF8 serine/arginine-rich splicing factor 8
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
THRAP3 thyroid hormone receptor associated protein 3
TJP2 tight junction protein 2
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
TRAF3IP3 TRAF3 interacting protein 3
TRIB3 tribbles pseudokinase 3
TULP3 tubby like protein 3
U2AF1 U2 small nuclear RNA auxiliary factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
U2SURP U2 snRNP-associated SURP domain containing
UBC ubiquitin C
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR35 WD repeat domain 35
WNK4 WNK lysine deficient protein kinase 4
WNT16 wingless-type MMTV integration site family, member 16
WWOX WW domain containing oxidoreductase
YAP1 Yes-associated protein 1
YLPM1 YLP motif containing 1
YTHDC1 YTH domain containing 1
YY1 YY1 transcription factor
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYND8 zinc finger, MYND-type containing 8
ZNF443 zinc finger protein 443
ZNF512B zinc finger protein 512B