DSTN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description destrin (actin depolymerizing factor)|The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 11034)
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Genes

301 genes differentially expressed following the DSTN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN2 claudin 2 2.60181
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.60181
TRIM10 tripartite motif containing 10 2.60181
DNASE1L2 deoxyribonuclease I-like 2 2.60181
CELA3B chymotrypsin-like elastase family, member 3B 2.60181
TM4SF1 transmembrane 4 L six family member 1 2.60181
PNMA5 paraneoplastic Ma antigen family member 5 2.60181
PCDHGB3 protocadherin gamma subfamily B, 3 2.60181
BLK BLK proto-oncogene, Src family tyrosine kinase 2.60181
ZNF492 zinc finger protein 492 2.60181
NPAP1 nuclear pore associated protein 1 2.60181
CARD18 caspase recruitment domain family, member 18 2.60181
PCDHA2 protocadherin alpha 2 2.60181
RAB41 RAB41, member RAS oncogene family 2.60181
SECTM1 secreted and transmembrane 1 2.60181
GUCA1C guanylate cyclase activator 1C 2.60181
CFHR3 complement factor H-related 3 2.60181
CD6 CD6 molecule 2.60181
SOX1 SRY (sex determining region Y)-box 1 2.60181
OR11H4 olfactory receptor, family 11, subfamily H, member 4 2.60181
TMEM191B transmembrane protein 191B 2.60181
FOXR1 forkhead box R1 2.60181
MUC22 mucin 22 2.60181
TREML1 triggering receptor expressed on myeloid cells-like 1 2.60181
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.60181
KRT73 keratin 73, type II 2.60181
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.60181
TAS2R13 taste receptor, type 2, member 13 2.60181
MYL5 myosin, light chain 5, regulatory 2.60181
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.60181
NPIPA8 nuclear pore complex interacting protein family, member A8 2.60181
OR1D2 olfactory receptor, family 1, subfamily D, member 2 2.60181
OC90 otoconin 90 2.60181
ARHGAP36 Rho GTPase activating protein 36 2.60181
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.60181
MSC musculin 2.60181
ASB10 ankyrin repeat and SOCS box containing 10 2.60181
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.60181
SHCBP1L SHC SH2-domain binding protein 1-like 2.60181
PTGFR prostaglandin F receptor (FP) 2.60181
LCN12 lipocalin 12 2.60181
ERAP2 endoplasmic reticulum aminopeptidase 2 2.60181
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.60181
FYB1 FYN binding protein 1 2.60181
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.60181
C3AR1 complement component 3a receptor 1 2.60181
MCHR2 melanin-concentrating hormone receptor 2 2.60181
GPX6 glutathione peroxidase 6 2.60181
TKFC triokinase/FMN cyclase 2.60181
CD300LF CD300 molecule-like family member f 2.60181
FMOD fibromodulin 2.60181
SLURP2 secreted LY6/PLAUR domain containing 2 2.60181
RTL9 retrotransposon Gag like 9 2.60181
CBY2 chibby family member 2 2.60181
OR56B2 olfactory receptor family 56 subfamily B member 2 2.60181
CIMIP7 ciliary microtubule inner protein 7 2.60181
LITAFD LITAF domain containing 2.60181
LINC02268 long intergenic non-protein coding RNA 2268 2.60181
CIMIP3 ciliary microtubule inner protein 3 2.60181
H2BW2 H2B.W histone 2 2.60181
TMEM270 transmembrane protein 270 2.60181
GARIN6 golgi associated RAB2 interactor family member 6 2.60181
ZNF607 zinc finger protein 607 2.60181
TMEM40 transmembrane protein 40 2.60181
MSH6 mutS homolog 6 2.60181
C7 complement component 7 2.60181
CLDN22 claudin 22 2.60181
CCR3 chemokine (C-C motif) receptor 3 2.60181
SLAMF7 SLAM family member 7 2.60181
GZMM granzyme M (lymphocyte met-ase 1) 2.60181
SCRT1 scratch family zinc finger 1 2.60181
SIM2 single-minded family bHLH transcription factor 2 2.60181
LRRC70 leucine rich repeat containing 70 2.60181
GPR85 G protein-coupled receptor 85 2.60181
DLK2 delta-like 2 homolog (Drosophila) 2.60181
RAB36 RAB36, member RAS oncogene family 2.60181
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.60181
KDM4C lysine (K)-specific demethylase 4C 2.60181
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.60181
GATA3 GATA binding protein 3 2.60181
CLEC6A C-type lectin domain family 6, member A 2.60181
OSTN osteocrin 2.60181
CNTN6 contactin 6 2.60181
UROC1 urocanate hydratase 1 2.60181
ZC2HC1C zinc finger, C2HC-type containing 1C 2.60181
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.60181
EVPLL envoplakin-like 2.60181
PCDHGA4 protocadherin gamma subfamily A, 4 2.60181
CDH10 cadherin 10, type 2 (T2-cadherin) 2.60181
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.60181
C11ORF16 chromosome 11 open reading frame 16 2.60181
FAM177B family with sequence similarity 177, member B 2.60181
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.60181
GOLGA6D golgin A6 family, member D 2.60181
WFDC5 WAP four-disulfide core domain 5 2.60181
TPPP3 tubulin polymerization-promoting protein family member 3 2.60181
KLHL41 kelch-like family member 41 2.60181
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.60181
EHF ets homologous factor 2.60181
CLDN34 claudin 34 2.60181
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.60181
CPA2 carboxypeptidase A2 (pancreatic) 2.60181
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.60181
CCL15 chemokine (C-C motif) ligand 15 2.60181
PRDM5 PR domain containing 5 2.60181
NPM2 nucleophosmin/nucleoplasmin 2 2.60181
CASQ2 calsequestrin 2 (cardiac muscle) 2.60181
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.60181
QRFP pyroglutamylated RFamide peptide 2.60181
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.60181
PLCD4 phospholipase C, delta 4 2.60181
NT5C1A 5'-nucleotidase, cytosolic IA 2.60181
SPHKAP SPHK1 interactor, AKAP domain containing 2.60181
DMRT1 doublesex and mab-3 related transcription factor 1 2.60181
ARL1 ADP-ribosylation factor-like 1 2.60181
DNLZ DNL-type zinc finger 2.60181
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.60181
C8A complement component 8, alpha polypeptide 2.60181
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.60181
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.60181
LRRC15 leucine rich repeat containing 15 2.60181
MRGPRE MAS-related GPR, member E 2.60181
VAX2 ventral anterior homeobox 2 2.60181
IL12A interleukin 12A 2.60181
TCF21 transcription factor 21 2.60181
ADM2 adrenomedullin 2 2.60181
FOXG1 forkhead box G1 2.60181
ITPKA inositol-trisphosphate 3-kinase A 2.60181
GCSAML germinal center-associated, signaling and motility-like 2.60181
TBC1D28 TBC1 domain family, member 28 2.60181
LRRC31 leucine rich repeat containing 31 2.60181
ANGPTL6 angiopoietin-like 6 2.60181
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.60181
CCNO cyclin O 2.60181
CARNS1 carnosine synthase 1 2.60181
CYBB cytochrome b-245, beta polypeptide 2.60181
ASCL1 achaete-scute family bHLH transcription factor 1 2.60181
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.60181
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.60181
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.60181
CD34 CD34 molecule 2.60181
NPC1L1 NPC1-like 1 2.60181
LRRC32 leucine rich repeat containing 32 2.60181
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.60181
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.60181
CLEC2A C-type lectin domain family 2, member A 2.60181
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.60181
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.60181
BMF Bcl2 modifying factor 2.58877
RPL30 ribosomal protein L30 2.55977
TSC22D3 TSC22 domain family, member 3 2.48365
NBPF8 neuroblastoma breakpoint family, member 8 2.47226
MFSD2A major facilitator superfamily domain containing 2A 2.46987
MIEF1 mitochondrial elongation factor 1 2.44906
MRPL23 mitochondrial ribosomal protein L23 2.44589
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.40926
TEAD4 TEA domain family member 4 2.4084
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.3581
NANOS3 nanos homolog 3 (Drosophila) 2.3581
RPL10 ribosomal protein L10 2.35005
LSM10 LSM10, U7 small nuclear RNA associated 2.34063
IFT80 intraflagellar transport 80 2.30184
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.25517
GPATCH1 G patch domain containing 1 2.24686
PTH2R parathyroid hormone 2 receptor 2.24388
RPS11 ribosomal protein S11 2.24206
FBP1 fructose-1,6-bisphosphatase 1 2.23736
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2.20134
NCAPD2 non-SMC condensin I complex, subunit D2 2.1852
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.1852
CD248 CD248 molecule, endosialin 2.18431
KLHL20 kelch-like family member 20 2.18431
XRN1 5'-3' exoribonuclease 1 2.18134
WDR35 WD repeat domain 35 2.17957
CKS2 CDC28 protein kinase regulatory subunit 2 2.15205
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.15205
RREB1 ras responsive element binding protein 1 2.15205
MYO3B myosin IIIB 2.14191
WDFY2 WD repeat and FYVE domain containing 2 2.13405
RBM27 RNA binding motif protein 27 2.12706
CENPX centromere protein X 2.11584
SPAG7 sperm associated antigen 7 2.11562
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 2.11385
LRRC28 leucine rich repeat containing 28 2.09815
ABITRAM actin binding transcription modulator 2.09567
NPIPB11 nuclear pore complex interacting protein family, member B11 2.0883
ZNF593 zinc finger protein 593 2.0883
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.08224
IGSF3 immunoglobulin superfamily, member 3 2.07752
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.07618
SLC35A5 solute carrier family 35, member A5 2.05334
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.05295
SNRPF small nuclear ribonucleoprotein polypeptide F 2.05182
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.04996
MCL1 myeloid cell leukemia 1 2.04996
UNC119 unc-119 homolog (C. elegans) 2.03847
SDAD1 SDA1 domain containing 1 2.03003
CPNE4 copine IV 2.01323
DRC9 dynein regulatory complex subunit 9 2.01323
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.00922
GPKOW G patch domain and KOW motifs 2.00715
DXO decapping exoribonuclease 2.00303

decreased expression

Symbol Name Standardized Value
DSTN destrin (actin depolymerizing factor) -5.3961
TEX53 testis expressed 53 -2.60181
PGAM4 phosphoglycerate mutase family member 4 -2.60181
PCDHB6 protocadherin beta 6 -2.60181
PGBDF plakoglobin binding and degradation factor -2.60181
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.60181
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.60181
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.60181
TGFB1 transforming growth factor, beta 1 -2.60181
RAPSN receptor-associated protein of the synapse -2.60181
BAAT bile acid CoA:amino acid N-acyltransferase -2.60181
UBA7 ubiquitin-like modifier activating enzyme 7 -2.60181
ANKK1 ankyrin repeat and kinase domain containing 1 -2.60181
PTK6 protein tyrosine kinase 6 -2.60181
BFSP2 beaded filament structural protein 2, phakinin -2.60181
PRELP proline/arginine-rich end leucine-rich repeat protein -2.60181
MYBPHL myosin binding protein H-like -2.60181
PRRT1B proline rich transmembrane protein 1B -2.60181
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.60181
C15ORF62 chromosome 15 open reading frame 62 -2.60181
HNF1B HNF1 homeobox B -2.60181
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.60181
C1QL2 complement component 1, q subcomponent-like 2 -2.60181
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.60181
HHEX hematopoietically expressed homeobox -2.60181
ZNF98 zinc finger protein 98 -2.60181
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -2.60181
OVGP1 oviductal glycoprotein 1, 120kDa -2.60181
TSSK4 testis-specific serine kinase 4 -2.60181
SIX3 SIX homeobox 3 -2.60181
WIZ widely interspaced zinc finger motifs -2.60181
MZB1 marginal zone B and B1 cell-specific protein -2.60181
MT1A metallothionein 1A -2.60181
NRSN1 neurensin 1 -2.60181
NT5C1B 5'-nucleotidase, cytosolic IB -2.60181
UTS2B urotensin 2B -2.60181
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.60181
CERKL ceramide kinase-like -2.60181
RND1 Rho family GTPase 1 -2.60181
PCDHGB2 protocadherin gamma subfamily B, 2 -2.60181
BIN2 bridging integrator 2 -2.60181
SCIN scinderin -2.60181
LYPD5 LY6/PLAUR domain containing 5 -2.60181
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.60181
ADRA2A adrenoceptor alpha 2A -2.60181
ZNF804B zinc finger protein 804B -2.60181
PCDHGA11 protocadherin gamma subfamily A, 11 -2.60181
STMN3 stathmin-like 3 -2.58877
PLA2G10 phospholipase A2, group X -2.53711
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.53711
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.5081
PKD1L1 polycystic kidney disease 1 like 1 -2.5081
H2BC4 H2B clustered histone 4 -2.5081
ANKRD63 ankyrin repeat domain 63 -2.50327
HS1BP3 HCLS1 binding protein 3 -2.47615
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.47247
STRIP1 striatin interacting protein 1 -2.47188
CARMIL2 capping protein regulator and myosin 1 linker 2 -2.42125
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -2.40259
MTCL1 microtubule crosslinking factor 1 -2.39892
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.32033
C6ORF89 chromosome 6 open reading frame 89 -2.31953
ALPL alkaline phosphatase, liver/bone/kidney -2.31817
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.31817
SENP1 SUMO1/sentrin specific peptidase 1 -2.31817
TMEM131L transmembrane 131 like -2.30373
NXPH2 neurexophilin 2 -2.30184
FGFR1 fibroblast growth factor receptor 1 -2.30006
ACVR1B activin A receptor, type IB -2.28928
MTERF4 mitochondrial transcription termination factor 4 -2.27103
SOS1 son of sevenless homolog 1 (Drosophila) -2.23119
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.19372
TET1 tet methylcytosine dioxygenase 1 -2.18451
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -2.18134
NLRP1 NLR family, pyrin domain containing 1 -2.17862
TMEM26 transmembrane protein 26 -2.15752
CCNJL cyclin J-like -2.15752
SMNDC1 survival motor neuron domain containing 1 -2.15752
PCDHAC1 protocadherin alpha subfamily C, 1 -2.15752
FKBP9 FK506 binding protein 9, 63 kDa -2.15205
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.15205
ACAD11 acyl-CoA dehydrogenase family, member 11 -2.1475
HSBP1L1 heat shock factor binding protein 1-like 1 -2.13907
QTMAN queuosine-tRNA mannosyltransferase -2.12676
ZNF724 zinc finger protein 724 -2.12227
CFAP410 cilia and flagella associated protein 410 -2.11584
EVPL envoplakin -2.08786
CAPN11 calpain 11 -2.08786
CCR5AS CCR5 antisense RNA -2.08163
EIF3E eukaryotic translation initiation factor 3, subunit E -2.07887
IL7 interleukin 7 -2.06955
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.06887
GMIP GEM interacting protein -2.06887
MORN2 MORN repeat containing 2 -2.05334
ZNF572 zinc finger protein 572 -2.03053
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.02599
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.02394
FZD5 frizzled class receptor 5 -2.00412
SON SON DNA binding protein -2.00149