DT-061_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DT-061 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DT-061_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.177326
VCL vinculin 0.167103
TLE4 transducin-like enhancer of split 4 0.104533
ZSWIM6 zinc finger, SWIM-type containing 6 0.0896319
PRKCA protein kinase C, alpha 0.0883582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0719388
NALF1 NALCN channel auxiliary factor 1 0.0716577
TPST1 tyrosylprotein sulfotransferase 1 0.0643847
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.062917
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0628213
BPTF bromodomain PHD finger transcription factor 0.0592647
VMP1 vacuole membrane protein 1 0.058414
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0560389
SLIT2 slit homolog 2 (Drosophila) 0.0526495
FAM107B family with sequence similarity 107, member B 0.0487595
FLT1 fms-related tyrosine kinase 1 0.0482799
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0473121
CEMIP cell migration inducing protein, hyaluronan binding 0.0468869
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0455316
ZNF638 zinc finger protein 638 0.0448504
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0444283
FERMT2 fermitin family member 2 0.0439831
INTS6 integrator complex subunit 6 0.0438004
HELZ helicase with zinc finger 0.0431887
NPAS2 neuronal PAS domain protein 2 0.0428348
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.041305
MEIS2 Meis homeobox 2 0.0403064
HOMER1 homer scaffolding protein 1 0.0397676
FNDC3A fibronectin type III domain containing 3A 0.0397662
ANTXR1 anthrax toxin receptor 1 0.0382554
MED13 mediator complex subunit 13 0.0374376
FNDC3B fibronectin type III domain containing 3B 0.0374066
PCBP3 poly(rC) binding protein 3 0.0359318
EXOC4 exocyst complex component 4 0.0347269
ITPRID2 ITPR interacting domain containing 2 0.0345147
ARHGAP5 Rho GTPase activating protein 5 0.0341461
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0340874
FAM13A family with sequence similarity 13, member A 0.0337058
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0335576
PCM1 pericentriolar material 1 0.0330263
PTPRM protein tyrosine phosphatase, receptor type, M 0.0311159
GPBP1 GC-rich promoter binding protein 1 0.0310977
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0309335
MBD5 methyl-CpG binding domain protein 5 0.0307359
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0306392
MCL1 myeloid cell leukemia 1 0.0304588
EXT1 exostosin glycosyltransferase 1 0.0303747
BCAS3 breast carcinoma amplified sequence 3 0.0289745
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0286617
PLAT plasminogen activator, tissue 0.0285402
RPL4 ribosomal protein L4 0.0281426
SEPTIN9 septin 9 0.0281177
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0279715
STK38L serine/threonine kinase 38 like 0.027808
GAB2 GRB2-associated binding protein 2 0.0277397
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0274113
MYO1E myosin IE 0.0273822
RAD51B RAD51 paralog B 0.0273212
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0271259
DNMBP dynamin binding protein 0.0266383
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0265881
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0261716
MYH9 myosin, heavy chain 9, non-muscle 0.0257291
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.02569
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0256165
ASPH aspartate beta-hydroxylase 0.0255006
MRTFA myocardin related transcription factor A 0.0254125
SMYD3 SET and MYND domain containing 3 0.0251492
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.025119
COL4A2 collagen, type IV, alpha 2 0.0250797
RAB30 RAB30, member RAS oncogene family 0.0248009
PDLIM5 PDZ and LIM domain 5 0.0247686
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0246815
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0245981
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0241279
GLCCI1 glucocorticoid induced 1 0.0236655
EEA1 early endosome antigen 1 0.023598
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0235656
CSNK1A1 casein kinase 1, alpha 1 0.0234786
UBAP1 ubiquitin associated protein 1 0.0233568
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0233036
HSPA8 heat shock 70kDa protein 8 0.0231212
SDCCAG8 serologically defined colon cancer antigen 8 0.0229633
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0228188
PTPRK protein tyrosine phosphatase, receptor type, K 0.0227801
FTO fat mass and obesity associated 0.0226287
FNBP1 formin binding protein 1 0.0225128
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0223642
VCAN versican 0.0221804
APLP2 amyloid beta (A4) precursor-like protein 2 0.0220253
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0219977
PDE10A phosphodiesterase 10A 0.0219632
NRIP1 nuclear receptor interacting protein 1 0.0219542
ELL2 elongation factor, RNA polymerase II, 2 0.0219287
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0217209
NPTN neuroplastin 0.0217205
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0216658
PALLD palladin, cytoskeletal associated protein 0.0216583
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.021577
TCF12 transcription factor 12 0.0213911

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.280868
PTMA prothymosin, alpha -0.105943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0943638
VIM vimentin -0.0726173
NRG1 neuregulin 1 -0.07062
RPS24 ribosomal protein S24 -0.0603477
ACTG1 actin gamma 1 -0.055412
RPL35A ribosomal protein L35a -0.0541913
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0525759
TMSB10 thymosin beta 10 -0.0503354
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0491409
RPL11 ribosomal protein L11 -0.0481323
RPL38 ribosomal protein L38 -0.0452215
RPL31 ribosomal protein L31 -0.0409777
SYT1 synaptotagmin I -0.0401141
RPS8 ribosomal protein S8 -0.0395077
RPS6 ribosomal protein S6 -0.0363929
TPT1 tumor protein, translationally-controlled 1 -0.0353235
RPS23 ribosomal protein S23 -0.0352848
FTL ferritin, light polypeptide -0.034361
RPL12 ribosomal protein L12 -0.034122
RPS16 ribosomal protein S16 -0.033385
KPNB1 karyopherin (importin) beta 1 -0.0329665
RPL23 ribosomal protein L23 -0.0323931
NDRG1 N-myc downstream regulated 1 -0.0318207
CD36 CD36 molecule (thrombospondin receptor) -0.0314936
GPC5 glypican 5 -0.0309695
NAP1L1 nucleosome assembly protein 1-like 1 -0.0307057
COL1A1 collagen, type I, alpha 1 -0.0303769
RPLP2 ribosomal protein, large, P2 -0.029961
S100A6 S100 calcium binding protein A6 -0.0295234
SETD5 SET domain containing 5 -0.029327
PDE4D phosphodiesterase 4D, cAMP-specific -0.0283289
RPS25 ribosomal protein S25 -0.0281825
CANX calnexin -0.0280063
RPL28 ribosomal protein L28 -0.026528
GARS1 glycyl-tRNA synthetase 1 -0.0259113
HM13 histocompatibility (minor) 13 -0.0247143
EIF5B eukaryotic translation initiation factor 5B -0.0246798
RTN4 reticulon 4 -0.0245758
RPL36 ribosomal protein L36 -0.0245677
RPS3 ribosomal protein S3 -0.0245182
IARS1 isoleucyl-tRNA synthetase 1 -0.024472
RPS21 ribosomal protein S21 -0.0243955
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0243852
ENO1 enolase 1, (alpha) -0.0240536
RAD21 RAD21 homolog (S. pombe) -0.0240363
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240089
GDF15 growth differentiation factor 15 -0.0237161
PIBF1 progesterone immunomodulatory binding factor 1 -0.0236141
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0235485
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0234415
GCC2 GRIP and coiled-coil domain containing 2 -0.0233168
RPS29 ribosomal protein S29 -0.023207
CALR calreticulin -0.0231974
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0227529
S100A10 S100 calcium binding protein A10 -0.0226115
RPS14 ribosomal protein S14 -0.0224497
RPS19 ribosomal protein S19 -0.0223969
RPL9 ribosomal protein L9 -0.021651
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.021514
IER3 immediate early response 3 -0.021468
DLC1 DLC1 Rho GTPase activating protein -0.0211973
H3-3B H3.3 histone B -0.0209261
PCDH9 protocadherin 9 -0.0208746
RPL34 ribosomal protein L34 -0.0206741
LPIN1 lipin 1 -0.0206513
RPL32 ribosomal protein L32 -0.0205667
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0201066
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0200003
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0199682
WDR45B WD repeat domain 45B -0.0198129
HMGB1 high mobility group box 1 -0.019783
CSDE1 cold shock domain containing E1, RNA-binding -0.0196698
RPLP1 ribosomal protein, large, P1 -0.0196341
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.019618
MAP1B microtubule-associated protein 1B -0.0192889
HMGA1 high mobility group AT-hook 1 -0.0189998
SRPK2 SRSF protein kinase 2 -0.018941
RANBP17 RAN binding protein 17 -0.0188789
RPL36A ribosomal protein L36a -0.0186389
RBMX RNA binding motif protein, X-linked -0.0186219
NCOR1 nuclear receptor corepressor 1 -0.0184785
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.01845
ZNFX1 zinc finger, NFX1-type containing 1 -0.018425
GNAS GNAS complex locus -0.0183709
NF1 neurofibromin 1 -0.0183405
KIF26A kinesin family member 26A -0.0183119
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0182058
OGA O-GlcNAcase -0.0181169
RPS27 ribosomal protein S27 -0.0180175
FN1 fibronectin 1 -0.017818
FBL fibrillarin -0.0177789
TTC3 tetratricopeptide repeat domain 3 -0.0176276
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0175069
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0174936
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0174633
MT2A metallothionein 2A -0.0174436
PCNP PEST proteolytic signal containing nuclear protein -0.0173666
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0172028