| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | DT-061 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the DT-061_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.329084 |
| SMAD3 | SMAD family member 3 | 0.136506 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.136122 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.115555 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.10534 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0932918 |
| INTS6 | integrator complex subunit 6 | 0.0870895 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0849624 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0825238 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0780889 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0762553 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0748498 |
| ANXA2 | annexin A2 | 0.0733096 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0712674 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0703899 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0653292 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0650452 |
| ASPH | aspartate beta-hydroxylase | 0.0638182 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0616668 |
| VMP1 | vacuole membrane protein 1 | 0.0596644 |
| MAP7 | microtubule-associated protein 7 | 0.0594523 |
| ERBIN | erbb2 interacting protein | 0.0573219 |
| EFNB2 | ephrin-B2 | 0.0569514 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.054698 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0515517 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0510577 |
| MCU | mitochondrial calcium uniporter | 0.0505628 |
| TJP1 | tight junction protein 1 | 0.0505612 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0505316 |
| MYO1E | myosin IE | 0.0496286 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0487375 |
| DST | dystonin | 0.047965 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0466435 |
| PRKCA | protein kinase C, alpha | 0.046159 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0459661 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0458556 |
| YAP1 | Yes-associated protein 1 | 0.0448172 |
| RNF213 | ring finger protein 213 | 0.0445592 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0440438 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.042862 |
| HKDC1 | hexokinase domain containing 1 | 0.0426954 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0420622 |
| RAD51B | RAD51 paralog B | 0.0419389 |
| DIAPH1 | diaphanous-related formin 1 | 0.0418634 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0416158 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0413706 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0406376 |
| MYO5B | myosin VB | 0.0406067 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0404933 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0400937 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0398398 |
| IFNGR1 | interferon gamma receptor 1 | 0.0396547 |
| ETV6 | ets variant 6 | 0.039474 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0390648 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0387989 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0386824 |
| FNIP1 | folliculin interacting protein 1 | 0.038559 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0385518 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0376131 |
| TMEM65 | transmembrane protein 65 | 0.0372559 |
| KYNU | kynureninase | 0.0368605 |
| BCL2L1 | BCL2-like 1 | 0.0367576 |
| PLSCR2 | phospholipid scramblase 2 | 0.0365948 |
| SP100 | SP100 nuclear antigen | 0.035779 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0346481 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.034439 |
| MYO10 | myosin X | 0.0343844 |
| VCL | vinculin | 0.0338027 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0334454 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0333676 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0333449 |
| USP53 | ubiquitin specific peptidase 53 | 0.0327914 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0323983 |
| PDZD8 | PDZ domain containing 8 | 0.032234 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0321449 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0320528 |
| ZNF292 | zinc finger protein 292 | 0.0316733 |
| MSI2 | musashi RNA-binding protein 2 | 0.0311424 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.031088 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0305178 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0304115 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0302172 |
| FNIP2 | folliculin interacting protein 2 | 0.029679 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0296266 |
| TRERF1 | transcriptional regulating factor 1 | 0.0294996 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0294895 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.0288864 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0288248 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0287305 |
| MED13 | mediator complex subunit 13 | 0.028586 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0285125 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0273254 |
| SIK3 | SIK family kinase 3 | 0.0271544 |
| JAK1 | Janus kinase 1 | 0.0269116 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0261684 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0259264 |
| RAB7A | RAB7A, member RAS oncogene family | 0.025879 |
| SLK | STE20-like kinase | 0.0258041 |
| FAT1 | FAT atypical cadherin 1 | 0.0256842 |
| NCKAP5 | NCK-associated protein 5 | 0.024826 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.139273 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.133624 |
| B2M | beta-2-microglobulin | -0.113657 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101716 |
| HLA-B | major histocompatibility complex, class I, B | -0.095937 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0939978 |
| PTMA | prothymosin, alpha | -0.0798975 |
| NDRG1 | N-myc downstream regulated 1 | -0.0675159 |
| LYZ | lysozyme | -0.0622006 |
| FTL | ferritin, light polypeptide | -0.0618572 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0600667 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0563719 |
| RPS6 | ribosomal protein S6 | -0.0562189 |
| EGR1 | early growth response 1 | -0.0541775 |
| RPL35A | ribosomal protein L35a | -0.0500489 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0493285 |
| RPLP1 | ribosomal protein, large, P1 | -0.0466251 |
| CANX | calnexin | -0.0456278 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0449985 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0438505 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0432289 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0414752 |
| LCN2 | lipocalin 2 | -0.0412457 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0393462 |
| TMSB10 | thymosin beta 10 | -0.0386057 |
| RPL34 | ribosomal protein L34 | -0.0383712 |
| RPL19 | ribosomal protein L19 | -0.0377343 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0370302 |
| HLA-C | major histocompatibility complex, class I, C | -0.0369813 |
| TXNIP | thioredoxin interacting protein | -0.0368623 |
| CALR | calreticulin | -0.0363807 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0360513 |
| RPL23 | ribosomal protein L23 | -0.0358863 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0357971 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0351497 |
| PKM | pyruvate kinase, muscle | -0.0329427 |
| MORF4L2 | mortality factor 4 like 2 | -0.0324192 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0323959 |
| SQSTM1 | sequestosome 1 | -0.0321832 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0316599 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0304413 |
| RRBP1 | ribosome binding protein 1 | -0.030159 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0301229 |
| EZR | ezrin | -0.0298936 |
| RPLP2 | ribosomal protein, large, P2 | -0.0298078 |
| RPS8 | ribosomal protein S8 | -0.0296883 |
| HDLBP | high density lipoprotein binding protein | -0.0282743 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0281281 |
| DIAPH3 | diaphanous-related formin 3 | -0.0280179 |
| RPS19 | ribosomal protein S19 | -0.0278037 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0275407 |
| RPL12 | ribosomal protein L12 | -0.0275374 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.027507 |
| GNAS | GNAS complex locus | -0.0274974 |
| IRF1 | interferon regulatory factor 1 | -0.0273242 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0264285 |
| AGR2 | anterior gradient 2 | -0.0261449 |
| HLA-E | major histocompatibility complex, class I, E | -0.0259656 |
| CSTB | cystatin B (stefin B) | -0.0259061 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0256909 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0255932 |
| AHI1 | Abelson helper integration site 1 | -0.0250796 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0249971 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0244977 |
| HLA-A | major histocompatibility complex, class I, A | -0.0242754 |
| RPL11 | ribosomal protein L11 | -0.0241699 |
| MKI67 | marker of proliferation Ki-67 | -0.0240821 |
| EPCAM | epithelial cell adhesion molecule | -0.0239899 |
| TPM4 | tropomyosin 4 | -0.0237965 |
| RNF149 | ring finger protein 149 | -0.0237627 |
| GOLGA2 | golgin A2 | -0.023695 |
| RPS13 | ribosomal protein S13 | -0.0235248 |
| JUN | jun proto-oncogene | -0.0233685 |
| RPS29 | ribosomal protein S29 | -0.0230302 |
| ACTG1 | actin gamma 1 | -0.022715 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.022697 |
| S100A6 | S100 calcium binding protein A6 | -0.0226462 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0226138 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0224566 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0224262 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0223663 |
| BRCA2 | breast cancer 2, early onset | -0.0223629 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0222781 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0222376 |
| RPL26 | ribosomal protein L26 | -0.0220306 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0219714 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0216709 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.021559 |
| GOLGA4 | golgin A4 | -0.0214437 |
| RPS3 | ribosomal protein S3 | -0.0212567 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0211464 |
| S100A10 | S100 calcium binding protein A10 | -0.0210765 |
| RPL37A | ribosomal protein L37a | -0.0207227 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0205711 |
| RPS23 | ribosomal protein S23 | -0.0205546 |
| RPS11 | ribosomal protein S11 | -0.0204088 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0203273 |
| UBC | ubiquitin C | -0.0202422 |
| HMGB1 | high mobility group box 1 | -0.0200533 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.019996 |
