| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | DT-061 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the DT-061_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.291276 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.194279 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.189589 |
| SVIL | supervillin | 0.146864 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117489 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.116717 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.108502 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0988702 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0865979 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0824323 |
| DSPP | dentin sialophosphoprotein | 0.0817756 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0812531 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0787586 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0774038 |
| FAM107B | family with sequence similarity 107, member B | 0.0768309 |
| ENO1 | enolase 1, (alpha) | 0.0707379 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.068955 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.068492 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0635962 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0614236 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0590078 |
| RPL4 | ribosomal protein L4 | 0.0580625 |
| JMJD1C | jumonji domain containing 1C | 0.0569582 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0548799 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0543597 |
| FOXP1 | forkhead box P1 | 0.0529648 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0523367 |
| KYNU | kynureninase | 0.0517905 |
| RPS8 | ribosomal protein S8 | 0.0515805 |
| RPL3 | ribosomal protein L3 | 0.051574 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0514687 |
| TXNRD1 | thioredoxin reductase 1 | 0.051021 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0491457 |
| CRY1 | cryptochrome circadian clock 1 | 0.0486031 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0477079 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0476512 |
| SIK3 | SIK family kinase 3 | 0.046971 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0440073 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0437563 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0428731 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0422351 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.042085 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0417531 |
| DSTN | destrin (actin depolymerizing factor) | 0.0409642 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.040606 |
| USP47 | ubiquitin specific peptidase 47 | 0.0405088 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0404029 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0395846 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0391516 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0386108 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.038405 |
| MT2A | metallothionein 2A | 0.0383044 |
| ASPH | aspartate beta-hydroxylase | 0.0372841 |
| FAT1 | FAT atypical cadherin 1 | 0.0370906 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0368565 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0368252 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0361644 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.036157 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0360179 |
| UBC | ubiquitin C | 0.0353955 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0353942 |
| JAK1 | Janus kinase 1 | 0.0352487 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0352393 |
| DIAPH1 | diaphanous-related formin 1 | 0.035228 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0351259 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0347482 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0347437 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0346666 |
| ITGAV | integrin, alpha V | 0.0346263 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0340605 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0340468 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0336996 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0336573 |
| AHSG | alpha-2-HS-glycoprotein | 0.0335916 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0335068 |
| RPS6 | ribosomal protein S6 | 0.0331524 |
| GOLGA4 | golgin A4 | 0.0329885 |
| SSR1 | signal sequence receptor, alpha | 0.0329371 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0328357 |
| LMO7 | LIM domain 7 | 0.0326957 |
| RTN4 | reticulon 4 | 0.0323105 |
| WAC | WW domain containing adaptor with coiled-coil | 0.032196 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0321548 |
| KIF1B | kinesin family member 1B | 0.0318444 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0317006 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0316819 |
| YME1L1 | YME1-like 1 ATPase | 0.0315853 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0315463 |
| SPAG9 | sperm associated antigen 9 | 0.0312883 |
| RPL5 | ribosomal protein L5 | 0.0307326 |
| CLIC4 | chloride intracellular channel 4 | 0.0304081 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0303495 |
| RPS12 | ribosomal protein S12 | 0.0301056 |
| FAM13A | family with sequence similarity 13, member A | 0.0300503 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0295873 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.029479 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0294462 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0291811 |
| TOP1 | topoisomerase (DNA) I | 0.0290794 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0290749 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.159203 |
| FN1 | fibronectin 1 | -0.134337 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.124949 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0861878 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0772207 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0663053 |
| C3 | complement component 3 | -0.0639456 |
| RNF213 | ring finger protein 213 | -0.0589597 |
| GPC6 | glypican 6 | -0.0536602 |
| APOA2 | apolipoprotein A-II | -0.0524038 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0517086 |
| CP | ceruloplasmin (ferroxidase) | -0.0489073 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0411326 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0410272 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0393711 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0375213 |
| GNAS | GNAS complex locus | -0.0354378 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.033451 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0320553 |
| TMEM123 | transmembrane protein 123 | -0.0318415 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0303315 |
| MSI2 | musashi RNA-binding protein 2 | -0.0291419 |
| EGR1 | early growth response 1 | -0.0286281 |
| PEG3 | paternally expressed 3 | -0.0282573 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0276912 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0250422 |
| PTCHD4 | patched domain containing 4 | -0.0248078 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0245178 |
| NDRG1 | N-myc downstream regulated 1 | -0.0244834 |
| RBM39 | RNA binding motif protein 39 | -0.0238026 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0235694 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0232641 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.023122 |
| ITGA1 | integrin, alpha 1 | -0.0221123 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0214163 |
| ATP10A | ATPase, class V, type 10A | -0.0213525 |
| TMEM51 | transmembrane protein 51 | -0.0204405 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0200856 |
| RPL35A | ribosomal protein L35a | -0.0200513 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0195135 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0188562 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0187481 |
| CMIP | c-Maf inducing protein | -0.0183288 |
| FOXN3 | forkhead box N3 | -0.0183271 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0182211 |
| APOE | apolipoprotein E | -0.0179974 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0177244 |
| LYZ | lysozyme | -0.0176821 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0176742 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0175486 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0175116 |
| MATN3 | matrilin 3 | -0.0174536 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0172619 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0171307 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0170982 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0169934 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0169761 |
| RIGI | RNA sensor RIG-I | -0.0169171 |
| CALD1 | caldesmon 1 | -0.0168866 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0168345 |
| CST3 | cystatin C | -0.0167947 |
| NFIA | nuclear factor I/A | -0.0167153 |
| A2M | alpha-2-macroglobulin | -0.0166851 |
| TMEM45B | transmembrane protein 45B | -0.0166845 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0166382 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0165675 |
| ZFHX3 | zinc finger homeobox 3 | -0.0164264 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0161726 |
| GPC3 | glypican 3 | -0.0161449 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.0160781 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0159983 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0159179 |
| APOC1 | apolipoprotein C-I | -0.0158361 |
| CTSD | cathepsin D | -0.0153975 |
| FKTN | fukutin | -0.0150832 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0148781 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0148356 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0148225 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0147357 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0147327 |
| KIZ | kizuna centrosomal protein | -0.0147261 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0146512 |
| RRBP1 | ribosome binding protein 1 | -0.0146033 |
| CXXC5 | CXXC finger protein 5 | -0.0144444 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0143853 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0139916 |
| PEG10 | paternally expressed 10 | -0.0139787 |
| NHSL1 | NHS-like 1 | -0.013829 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0136976 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0136496 |
| MX2 | MX dynamin-like GTPase 2 | -0.0136107 |
| GSE1 | Gse1 coiled-coil protein | -0.0135477 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0133967 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0130455 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.013043 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0129957 |
| NREP | neuronal regeneration related protein | -0.012994 |
| NOL4L | nucleolar protein 4-like | -0.0128953 |
| AGXT | alanine-glyoxylate aminotransferase | -0.012716 |
| HMGA1 | high mobility group AT-hook 1 | -0.0127159 |
