| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | DT-061 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the DT-061_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.203786 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0899441 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0809961 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0579636 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0528643 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0495893 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0467056 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0452899 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0441205 |
| EXOC4 | exocyst complex component 4 | 0.0425458 |
| INTS6 | integrator complex subunit 6 | 0.0380107 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0371874 |
| RRM2 | ribonucleotide reductase M2 | 0.0370824 |
| HOMER1 | homer scaffolding protein 1 | 0.036823 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0360784 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0357701 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0357348 |
| JMJD1C | jumonji domain containing 1C | 0.0336403 |
| DOCK5 | dedicator of cytokinesis 5 | 0.03361 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0335131 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0334773 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0327576 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0318906 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0306014 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0303979 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0301524 |
| RPL4 | ribosomal protein L4 | 0.0296034 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0294869 |
| NABP1 | nucleic acid binding protein 1 | 0.0282754 |
| PRKCE | protein kinase C, epsilon | 0.0281001 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0274276 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0274264 |
| RCOR1 | REST corepressor 1 | 0.0271556 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0266262 |
| TPM3 | tropomyosin 3 | 0.0261975 |
| FMNL2 | formin-like 2 | 0.0257967 |
| RAD51B | RAD51 paralog B | 0.025714 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0256713 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0252119 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0248263 |
| ANO6 | anoctamin 6 | 0.0247249 |
| SIK3 | SIK family kinase 3 | 0.0245622 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0241963 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0239952 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0238223 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0236508 |
| E2F3 | E2F transcription factor 3 | 0.0234887 |
| CRY1 | cryptochrome circadian clock 1 | 0.0228396 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0226703 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0225248 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0222757 |
| CMIP | c-Maf inducing protein | 0.0220667 |
| TRIM59 | tripartite motif containing 59 | 0.0220246 |
| DST | dystonin | 0.0219789 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0218947 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.0215629 |
| USP34 | ubiquitin specific peptidase 34 | 0.0208521 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.020718 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0206403 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0204659 |
| HMGA2 | high mobility group AT-hook 2 | 0.0201452 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0200892 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0200412 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0200282 |
| SCFD1 | sec1 family domain containing 1 | 0.0199684 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0199583 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.019674 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0193532 |
| AFF3 | AF4/FMR2 family, member 3 | 0.019019 |
| BRD2 | bromodomain containing 2 | 0.0189906 |
| VMP1 | vacuole membrane protein 1 | 0.0187328 |
| FOXP1 | forkhead box P1 | 0.0186088 |
| NF1 | neurofibromin 1 | 0.0185528 |
| RPL3 | ribosomal protein L3 | 0.018407 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0184049 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0182371 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0181765 |
| ETNK1 | ethanolamine kinase 1 | 0.0181186 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0180522 |
| GPHN | gephyrin | 0.0180435 |
| VCL | vinculin | 0.017879 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0176613 |
| YAP1 | Yes-associated protein 1 | 0.0175871 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0173645 |
| ASPH | aspartate beta-hydroxylase | 0.0171998 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0171554 |
| HDAC9 | histone deacetylase 9 | 0.0170803 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0170004 |
| RBM19 | RNA binding motif protein 19 | 0.0169329 |
| INO80 | INO80 complex subunit | 0.0168622 |
| TUT7 | terminal uridylyl transferase 7 | 0.0167271 |
| ATP13A3 | ATPase type 13A3 | 0.016634 |
| CALD1 | caldesmon 1 | 0.016603 |
| FNDC3B | fibronectin type III domain containing 3B | 0.016466 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0162918 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0162074 |
| COPA | coatomer protein complex, subunit alpha | 0.0161769 |
| LRRC23 | leucine rich repeat containing 23 | 0.0161367 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0161121 |
| C1S | complement component 1, s subcomponent | 0.016089 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.141649 |
| VIM | vimentin | -0.121475 |
| PTMA | prothymosin, alpha | -0.117466 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115889 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.115848 |
| TMSB10 | thymosin beta 10 | -0.109636 |
| UBC | ubiquitin C | -0.0880485 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0766733 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0758449 |
| RPL23 | ribosomal protein L23 | -0.0726647 |
| RPS27A | ribosomal protein S27a | -0.0615949 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0536685 |
| PCBP2 | poly(rC) binding protein 2 | -0.052999 |
| RPL35A | ribosomal protein L35a | -0.0485572 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0476485 |
| CANX | calnexin | -0.0466109 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0464479 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0449726 |
| TXNRD1 | thioredoxin reductase 1 | -0.0447178 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0437495 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0436943 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0431535 |
| RPL26 | ribosomal protein L26 | -0.0430937 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0410018 |
| BBX | bobby sox homolog (Drosophila) | -0.0405754 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0398206 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0388603 |
| RPS21 | ribosomal protein S21 | -0.03846 |
| XPO1 | exportin 1 | -0.0383009 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0378045 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0375245 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0371757 |
| RPS8 | ribosomal protein S8 | -0.036496 |
| TPI1 | triosephosphate isomerase 1 | -0.0360126 |
| CAVIN1 | caveolae associated protein 1 | -0.0354575 |
| ENO1 | enolase 1, (alpha) | -0.034957 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0345727 |
| RPL37A | ribosomal protein L37a | -0.0344076 |
| GNAS | GNAS complex locus | -0.0333503 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0321334 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0315927 |
| AHNAK | AHNAK nucleoprotein | -0.0311931 |
| RPL19 | ribosomal protein L19 | -0.0304839 |
| RPS29 | ribosomal protein S29 | -0.030254 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0300636 |
| SEPTIN7 | septin 7 | -0.029784 |
| OGA | O-GlcNAcase | -0.0294666 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0292601 |
| RPL34 | ribosomal protein L34 | -0.0291899 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0288846 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0288153 |
| RBM25 | RNA binding motif protein 25 | -0.0286154 |
| PFN1 | profilin 1 | -0.0282379 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0281236 |
| WDR45B | WD repeat domain 45B | -0.028018 |
| RSF1 | remodeling and spacing factor 1 | -0.0279697 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0279696 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.027902 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0277108 |
| RPS3 | ribosomal protein S3 | -0.0275929 |
| RPL38 | ribosomal protein L38 | -0.0274747 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0272486 |
| LDHB | lactate dehydrogenase B | -0.0271139 |
| S100A6 | S100 calcium binding protein A6 | -0.0270108 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0269869 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0268327 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0268248 |
| RPS19 | ribosomal protein S19 | -0.0268219 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0266473 |
| WASF2 | WAS protein family, member 2 | -0.0265178 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0264873 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0263739 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0258466 |
| SRP72 | signal recognition particle 72kDa | -0.0257433 |
| PHIP | pleckstrin homology domain interacting protein | -0.0253397 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0253133 |
| RPLP1 | ribosomal protein, large, P1 | -0.0251488 |
| RPL12 | ribosomal protein L12 | -0.0250622 |
| TNPO1 | transportin 1 | -0.0250219 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.024452 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0244292 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0242122 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0241118 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0238241 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0234176 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0233023 |
| ZFR | zinc finger RNA binding protein | -0.0232564 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0231853 |
| RPL32 | ribosomal protein L32 | -0.023152 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0231074 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0230497 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0227849 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.022769 |
| PKM | pyruvate kinase, muscle | -0.0224683 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.022433 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0222038 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0220856 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0220288 |
| RPLP2 | ribosomal protein, large, P2 | -0.0219608 |
| KIF5B | kinesin family member 5B | -0.0218223 |
