DT-061_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DT-061 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DT-061_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.145372
NRXN3 neurexin 3 0.125642
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.12386
FTH1 ferritin, heavy polypeptide 1 0.0838313
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0737201
SEC24D SEC24 family member D 0.0722387
ZSWIM6 zinc finger, SWIM-type containing 6 0.0705718
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0686356
ELL2 elongation factor, RNA polymerase II, 2 0.063542
AKAP12 A kinase (PRKA) anchor protein 12 0.0625227
UBC ubiquitin C 0.0597262
AKAP9 A kinase (PRKA) anchor protein 9 0.0596432
B2M beta-2-microglobulin 0.0578952
GOLGB1 golgin B1 0.0578293
FNIP1 folliculin interacting protein 1 0.0562116
FAM13A family with sequence similarity 13, member A 0.0559254
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.055275
ESYT2 extended synaptotagmin-like protein 2 0.0521615
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0496867
COPA coatomer protein complex, subunit alpha 0.049442
ALK anaplastic lymphoma receptor tyrosine kinase 0.0489672
HMGA2 high mobility group AT-hook 2 0.0480662
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0476379
RAB1A RAB1A, member RAS oncogene family 0.0476333
IQGAP1 IQ motif containing GTPase activating protein 1 0.0473883
FNDC3B fibronectin type III domain containing 3B 0.0469508
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0462689
ANXA5 annexin A5 0.045541
COL6A3 collagen, type VI, alpha 3 0.0450482
SEC31A SEC31 homolog A (S. cerevisiae) 0.0445404
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0437255
ATXN1 ataxin 1 0.0433102
USP34 ubiquitin specific peptidase 34 0.0428498
COPB1 coatomer protein complex, subunit beta 1 0.0420409
SEC24A SEC24 family member A 0.0418282
COG6 component of oligomeric golgi complex 6 0.0413702
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0403005
PDIA6 protein disulfide isomerase family A, member 6 0.0396334
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.038996
KYNU kynureninase 0.0383381
PIBF1 progesterone immunomodulatory binding factor 1 0.0379301
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0373073
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0369576
ZBTB20 zinc finger and BTB domain containing 20 0.0363307
TMEM165 transmembrane protein 165 0.0361077
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0358932
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0355773
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0355066
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0353111
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0351678
PDIA4 protein disulfide isomerase family A, member 4 0.0350985
AHNAK AHNAK nucleoprotein 0.034871
HIPK2 homeodomain interacting protein kinase 2 0.0348143
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0346172
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.03461
DSCAM Down syndrome cell adhesion molecule 0.0346023
RNF24 ring finger protein 24 0.0345359
ECE1 endothelin converting enzyme 1 0.0344321
SUCO SUN domain containing ossification factor 0.0344061
TTC3 tetratricopeptide repeat domain 3 0.0343338
CLIP2 CAP-GLY domain containing linker protein 2 0.0342168
STC1 stanniocalcin 1 0.0341837
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0340663
IL6ST interleukin 6 signal transducer 0.0339674
SHB Src homology 2 domain containing adaptor protein B 0.0334457
YEATS2 YEATS domain containing 2 0.0332467
LIMS1 LIM and senescent cell antigen-like domains 1 0.0332153
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.033215
IGFBP7 insulin-like growth factor binding protein 7 0.032828
SSR1 signal sequence receptor, alpha 0.0327807
VMP1 vacuole membrane protein 1 0.0322981
RSAD2 radical S-adenosyl methionine domain containing 2 0.0322172
TPM3 tropomyosin 3 0.032137
UBA6 ubiquitin-like modifier activating enzyme 6 0.031867
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0317569
AFF4 AF4/FMR2 family, member 4 0.0315184
CADM1 cell adhesion molecule 1 0.0312544
NECTIN3 nectin cell adhesion molecule 3 0.0311109
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308581
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0306342
ZMIZ1 zinc finger, MIZ-type containing 1 0.0305943
PTK2 protein tyrosine kinase 2 0.0304106
WASF2 WAS protein family, member 2 0.0300364
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0296595
CDK6 cyclin-dependent kinase 6 0.0296046
COG5 component of oligomeric golgi complex 5 0.029603
ENO1 enolase 1, (alpha) 0.0295553
RND3 Rho family GTPase 3 0.0295312
SMAD3 SMAD family member 3 0.0295241
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0289806
TENT2 terminal nucleotidyltransferase 2 0.0287704
EFNA5 ephrin-A5 0.0287678
DPYSL2 dihydropyrimidinase-like 2 0.0287067
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.028614
ZNF395 zinc finger protein 395 0.0285805
HDLBP high density lipoprotein binding protein 0.0284869
GLG1 golgi glycoprotein 1 0.0283726
MYO9A myosin IXA 0.0283543
CD44 CD44 molecule (Indian blood group) 0.0283528
ITCH itchy E3 ubiquitin protein ligase 0.0282776

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.190192
FN1 fibronectin 1 -0.113871
F3 coagulation factor III (thromboplastin, tissue factor) -0.104163
TMSB10 thymosin beta 10 -0.102045
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0886894
MT1X metallothionein 1X -0.0854827
MT2A metallothionein 2A -0.0853571
PTMA prothymosin, alpha -0.0839163
HLA-C major histocompatibility complex, class I, C -0.0810729
COL1A1 collagen, type I, alpha 1 -0.0703724
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0618137
VIM vimentin -0.0612434
COL1A2 collagen, type I, alpha 2 -0.0598279
POTEF POTE ankyrin domain family, member F -0.0567193
WSB1 WD repeat and SOCS box containing 1 -0.0559649
ZMYND8 zinc finger, MYND-type containing 8 -0.0503873
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0490924
RPS24 ribosomal protein S24 -0.048928
PDE4D phosphodiesterase 4D, cAMP-specific -0.047934
ZFAND3 zinc finger, AN1-type domain 3 -0.0455551
LOX lysyl oxidase -0.0428291
S100A9 S100 calcium binding protein A9 -0.0413824
RPL35A ribosomal protein L35a -0.0408862
COL7A1 collagen, type VII, alpha 1 -0.0386713
CALD1 caldesmon 1 -0.038545
MACF1 microtubule-actin crosslinking factor 1 -0.0380409
RPS19 ribosomal protein S19 -0.0374659
HLA-B major histocompatibility complex, class I, B -0.0363851
PSD3 pleckstrin and Sec7 domain containing 3 -0.0359184
ACTG1 actin gamma 1 -0.0358835
FAM20C family with sequence similarity 20, member C -0.0354589
GARS1 glycyl-tRNA synthetase 1 -0.0343465
RRBP1 ribosome binding protein 1 -0.0343386
RPL37A ribosomal protein L37a -0.0341535
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0332184
RPS23 ribosomal protein S23 -0.0321691
DST dystonin -0.0320928
NAV2 neuron navigator 2 -0.0319109
CMIP c-Maf inducing protein -0.0313087
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0311882
SLC38A1 solute carrier family 38, member 1 -0.0309172
BASP1 brain abundant, membrane attached signal protein 1 -0.0307777
TNNC1 troponin C type 1 (slow) -0.0307722
RPL26 ribosomal protein L26 -0.0305832
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0302141
PGK1 phosphoglycerate kinase 1 -0.0300254
RPS5 ribosomal protein S5 -0.0297547
COL5A2 collagen, type V, alpha 2 -0.0291511
THOC2 THO complex 2 -0.0290493
GNAS GNAS complex locus -0.0289536
PDE10A phosphodiesterase 10A -0.0288886
FMNL2 formin-like 2 -0.0287137
GSE1 Gse1 coiled-coil protein -0.0285641
NALF1 NALCN channel auxiliary factor 1 -0.028116
RPL12 ribosomal protein L12 -0.0280784
FTL ferritin, light polypeptide -0.0271238
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0268604
FYN FYN proto-oncogene, Src family tyrosine kinase -0.026617
COL6A2 collagen, type VI, alpha 2 -0.0265264
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0262703
RPS6 ribosomal protein S6 -0.0261516
DCAF7 DDB1 and CUL4 associated factor 7 -0.0260443
NDUFA4 NDUFA4, mitochondrial complex associated -0.0259901
PTN pleiotrophin -0.0259414
TNS3 tensin 3 -0.0258912
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0256844
PFN1 profilin 1 -0.025639
DIAPH3 diaphanous-related formin 3 -0.0253153
ENAH enabled homolog (Drosophila) -0.0252081
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0251278
KDM2A lysine (K)-specific demethylase 2A -0.025107
COL6A1 collagen, type VI, alpha 1 -0.0249948
RPS11 ribosomal protein S11 -0.0249482
STK17A serine/threonine kinase 17a -0.0245832
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0245238
FBN1 fibrillin 1 -0.0244605
TUBB tubulin, beta class I -0.0242169
RPS10 ribosomal protein S10 -0.0239562
NPEPPS aminopeptidase puromycin sensitive -0.0239369
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0232538
GANAB glucosidase, alpha; neutral AB -0.0232156
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0232038
ARHGAP24 Rho GTPase activating protein 24 -0.0231927
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0231715
RPLP1 ribosomal protein, large, P1 -0.0230742
SRPK2 SRSF protein kinase 2 -0.0230295
NIPBL Nipped-B homolog (Drosophila) -0.0226791
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0225675
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0222949
RNF213 ring finger protein 213 -0.0219074
CLINT1 clathrin interactor 1 -0.0215824
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0214827
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0210185
ATP11B ATPase, class VI, type 11B -0.0209312
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.0207671
ACBD6 acyl-CoA binding domain containing 6 -0.0206551
NAMPT nicotinamide phosphoribosyltransferase -0.0206544
GPC6 glypican 6 -0.0205964
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0205359
RPS29 ribosomal protein S29 -0.0203597