DTP3_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.145028
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.127186
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.106866
MLPH melanophilin 0.102851
SRRM2 serine/arginine repetitive matrix 2 0.0972011
ARGLU1 arginine and glutamate rich 1 0.0962719
SMAD3 SMAD family member 3 0.095451
MYH9 myosin, heavy chain 9, non-muscle 0.0913752
SPTBN1 spectrin, beta, non-erythrocytic 1 0.080239
EPHB2 EPH receptor B2 0.0734205
VEGFA vascular endothelial growth factor A 0.0629508
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0549887
AKAP13 A kinase (PRKA) anchor protein 13 0.0509398
SORBS1 sorbin and SH3 domain containing 1 0.0507563
NCOR2 nuclear receptor corepressor 2 0.0505924
ASPH aspartate beta-hydroxylase 0.049083
SH3PXD2A SH3 and PX domains 2A 0.0481399
DST dystonin 0.0471024
MSI2 musashi RNA-binding protein 2 0.046954
FAT1 FAT atypical cadherin 1 0.046616
ABHD2 abhydrolase domain containing 2 0.0463916
YAP1 Yes-associated protein 1 0.0448843
TRIO trio Rho guanine nucleotide exchange factor 0.0446201
CTNND1 catenin (cadherin-associated protein), delta 1 0.0431839
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.042297
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0418014
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0415579
HDAC4 histone deacetylase 4 0.0414945
SHB Src homology 2 domain containing adaptor protein B 0.0410245
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0389919
DSCAM Down syndrome cell adhesion molecule 0.0388122
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0381104
APP amyloid beta (A4) precursor protein 0.0379651
BICRAL BICRA like chromatin remodeling complex associated protein 0.0379565
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0375827
KDM4C lysine (K)-specific demethylase 4C 0.0373337
VMP1 vacuole membrane protein 1 0.037058
EEF2 eukaryotic translation elongation factor 2 0.0364689
DIAPH1 diaphanous-related formin 1 0.0363599
TRERF1 transcriptional regulating factor 1 0.0358033
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0355017
LCN2 lipocalin 2 0.0351762
CDHR2 cadherin-related family member 2 0.0350662
SEPTIN9 septin 9 0.0341848
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.033241
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0329473
ATXN1 ataxin 1 0.032401
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0319822
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0318659
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0315948
NIBAN2 niban apoptosis regulator 2 0.0315572
AFF1 AF4/FMR2 family, member 1 0.0314225
ACIN1 apoptotic chromatin condensation inducer 1 0.0313029
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0312879
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0310249
NONO non-POU domain containing, octamer-binding 0.0306032
KRT8 keratin 8, type II 0.0305997
ANKRD11 ankyrin repeat domain 11 0.0302345
NKD1 naked cuticle homolog 1 (Drosophila) 0.0302029
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0301647
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0301278
DSPP dentin sialophosphoprotein 0.0300278
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0299492
ATP11A ATPase, class VI, type 11A 0.0298063
RBM39 RNA binding motif protein 39 0.0293361
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029242
PADI1 peptidyl arginine deiminase, type I 0.0288593
APOL1 apolipoprotein L, 1 0.0288132
MACF1 microtubule-actin crosslinking factor 1 0.0286234
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0280651
MINK1 misshapen-like kinase 1 0.0279555
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0277036
SLK STE20-like kinase 0.0273973
FNIP2 folliculin interacting protein 2 0.027396
STYXL2 serine/threonine/tyrosine interacting like 2 0.0273837
MYO10 myosin X 0.0273644
SFTPA2 surfactant protein A2 0.0273444
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0270776
RPL3 ribosomal protein L3 0.0267446
SAMD4A sterile alpha motif domain containing 4A 0.026608
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0262844
HKDC1 hexokinase domain containing 1 0.0262214
EIF4B eukaryotic translation initiation factor 4B 0.0257768
PCBP2 poly(rC) binding protein 2 0.0257689
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0256798
APOL2 apolipoprotein L, 2 0.0250858
PUM1 pumilio RNA-binding family member 1 0.0249224
IFNGR1 interferon gamma receptor 1 0.0246719
RBM26 RNA binding motif protein 26 0.024642
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0243064
HYOU1 hypoxia up-regulated 1 0.0239657
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0238217
ERCC5 excision repair cross-complementation group 5 0.0236676
TMEM65 transmembrane protein 65 0.0235776
PDZD8 PDZ domain containing 8 0.0234913
KIF16B kinesin family member 16B 0.0232201
MPRIP myosin phosphatase Rho interacting protein 0.0231342
MYO1E myosin IE 0.022978
ITGA6 integrin, alpha 6 0.0229237
PFKP phosphofructokinase, platelet 0.022874

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.167543
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128572
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0950369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0880322
XAF1 XIAP associated factor 1 -0.0745894
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0703493
PLSCR1 phospholipid scramblase 1 -0.0612958
RIGI RNA sensor RIG-I -0.0611011
H1-0 H1.0 linker histone -0.05919
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0579666
NPSR1 neuropeptide S receptor 1 -0.0568091
TXNIP thioredoxin interacting protein -0.054995
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.053515
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0514867
SP100 SP100 nuclear antigen -0.0506641
TM4SF1 transmembrane 4 L six family member 1 -0.0503113
IFI6 interferon, alpha-inducible protein 6 -0.0474152
EGR1 early growth response 1 -0.0460312
PMP22 peripheral myelin protein 22 -0.0447045
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0446589
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0441024
VCL vinculin -0.0432687
STS steroid sulfatase (microsomal), isozyme S -0.0432152
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0411242
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.040964
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0397072
ZMYND8 zinc finger, MYND-type containing 8 -0.0396522
RPLP1 ribosomal protein, large, P1 -0.0393887
MX2 MX dynamin-like GTPase 2 -0.0385856
GNAS GNAS complex locus -0.038353
ANXA2 annexin A2 -0.0366617
MUC20 mucin 20, cell surface associated -0.0364363
PATJ PATJ crumbs cell polarity complex component -0.0360014
NCOA7 nuclear receptor coactivator 7 -0.0358679
RABGAP1L RAB GTPase activating protein 1-like -0.0351475
PTMA prothymosin, alpha -0.0340556
TMSB10 thymosin beta 10 -0.0329307
PDIA3 protein disulfide isomerase family A, member 3 -0.0329297
PERP PERP, TP53 apoptosis effector -0.0327568
RPL34 ribosomal protein L34 -0.032397
ZBTB20 zinc finger and BTB domain containing 20 -0.03215
UBC ubiquitin C -0.0320322
NCKAP5 NCK-associated protein 5 -0.0317561
SQSTM1 sequestosome 1 -0.0317262
TNRC6B trinucleotide repeat containing 6B -0.0314636
ARF1 ADP-ribosylation factor 1 -0.0311422
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0310828
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.030799
UFM1 ubiquitin-fold modifier 1 -0.0301459
RPS6 ribosomal protein S6 -0.0294718
ERBIN erbb2 interacting protein -0.0293394
NF1 neurofibromin 1 -0.0291287
HLA-E major histocompatibility complex, class I, E -0.0281923
STAU1 staufen double-stranded RNA binding protein 1 -0.0276442
RPS8 ribosomal protein S8 -0.0271992
S100A10 S100 calcium binding protein A10 -0.0271554
GOLGB1 golgin B1 -0.0271212
FTH1 ferritin, heavy polypeptide 1 -0.0270304
AHI1 Abelson helper integration site 1 -0.0270191
HMGB1 high mobility group box 1 -0.0269609
RPL35A ribosomal protein L35a -0.0265828
NIPSNAP2 nipsnap homolog 2 -0.0265157
KLF6 Kruppel-like factor 6 -0.0263678
SSH2 slingshot protein phosphatase 2 -0.0262381
SLC38A1 solute carrier family 38, member 1 -0.0256315
GCC2 GRIP and coiled-coil domain containing 2 -0.0253816
ANKRD10 ankyrin repeat domain 10 -0.0252872
RBBP6 retinoblastoma binding protein 6 -0.0252661
IFIH1 interferon induced with helicase C domain 1 -0.0252591
TMEM263 transmembrane protein 263 -0.0252209
FBXO34 F-box protein 34 -0.0249398
VDAC1 voltage-dependent anion channel 1 -0.0249354
RPS24 ribosomal protein S24 -0.0249242
TAS2R14 taste receptor, type 2, member 14 -0.0248905
ABLIM1 actin binding LIM protein 1 -0.0246469
APOL6 apolipoprotein L, 6 -0.0244095
CANX calnexin -0.0243559
FTL ferritin, light polypeptide -0.0240931
ENO1 enolase 1, (alpha) -0.0237255
COPB1 coatomer protein complex, subunit beta 1 -0.0235335
XRN1 5'-3' exoribonuclease 1 -0.0232932
MX1 MX dynamin-like GTPase 1 -0.0232253
RAB1A RAB1A, member RAS oncogene family -0.0228727
BLZF1 basic leucine zipper nuclear factor 1 -0.0227446
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0227441
SAMD9 sterile alpha motif domain containing 9 -0.02272
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.022714
LYZ lysozyme -0.022683
RAB7A RAB7A, member RAS oncogene family -0.0225743
RPS11 ribosomal protein S11 -0.0224976
SAMD9L sterile alpha motif domain containing 9-like -0.0224377
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0223593
TMEM62 transmembrane protein 62 -0.0220243
RPL12 ribosomal protein L12 -0.021991
NT5C2 5'-nucleotidase, cytosolic II -0.021989
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.021985
CLYBL citrate lyase beta like -0.021836
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0218099
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0215927
SAMD12 sterile alpha motif domain containing 12 -0.0214836