DTP3_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.138636
MYH9 myosin, heavy chain 9, non-muscle 0.110512
CEMIP cell migration inducing protein, hyaluronan binding 0.081936
MACF1 microtubule-actin crosslinking factor 1 0.0664861
SMAD3 SMAD family member 3 0.0642559
MSN moesin 0.0640691
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0639147
BLCAP bladder cancer associated protein 0.0618146
PDE4D phosphodiesterase 4D, cAMP-specific 0.0616367
PODXL podocalyxin-like 0.0603655
MTSS1 metastasis suppressor 1 0.0589653
PDLIM5 PDZ and LIM domain 5 0.0553396
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0541106
BCAR3 breast cancer anti-estrogen resistance 3 0.0509994
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0500384
NAV2 neuron navigator 2 0.0493853
PRELID2 PRELI domain containing 2 0.0478836
NCOR2 nuclear receptor corepressor 2 0.0453528
DOCK5 dedicator of cytokinesis 5 0.045226
LAMA5 laminin, alpha 5 0.0422703
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0408334
AHNAK AHNAK nucleoprotein 0.0405846
MPRIP myosin phosphatase Rho interacting protein 0.0400807
EFNA5 ephrin-A5 0.0397715
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0391225
TNIP1 TNFAIP3 interacting protein 1 0.0388714
RAI14 retinoic acid induced 14 0.0372678
CD59 CD59 molecule, complement regulatory protein 0.037153
NRIP1 nuclear receptor interacting protein 1 0.0368232
BCL2L1 BCL2-like 1 0.0362373
TIMP3 TIMP metallopeptidase inhibitor 3 0.0360506
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0355572
RIN2 Ras and Rab interactor 2 0.0349941
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0341715
FLNB filamin B, beta 0.0341673
AOPEP aminopeptidase O (putative) 0.033712
MYOF myoferlin 0.0336071
TGM2 transglutaminase 2 0.0335777
SOX13 SRY (sex determining region Y)-box 13 0.0334014
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0326444
CEP250 centrosomal protein 250kDa 0.0321617
FLNA filamin A, alpha 0.0319704
DOCK4 dedicator of cytokinesis 4 0.0317101
MEGF6 multiple EGF-like-domains 6 0.0316913
CAPRIN2 caprin family member 2 0.0316677
SMYD3 SET and MYND domain containing 3 0.0316178
AMOTL1 angiomotin like 1 0.0316132
DST dystonin 0.0314913
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0311079
RAD51B RAD51 paralog B 0.0299824
SH3PXD2A SH3 and PX domains 2A 0.0298116
CMIP c-Maf inducing protein 0.0294602
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0294394
FOXP1 forkhead box P1 0.0291376
OSMR oncostatin M receptor 0.0290687
GRB10 growth factor receptor-bound protein 10 0.0285813
ARGLU1 arginine and glutamate rich 1 0.0284755
EXT1 exostosin glycosyltransferase 1 0.0282235
JAG1 jagged 1 0.0280878
AKAP13 A kinase (PRKA) anchor protein 13 0.0280459
ASPH aspartate beta-hydroxylase 0.0277873
NIBAN2 niban apoptosis regulator 2 0.0277302
SRRM2 serine/arginine repetitive matrix 2 0.0274757
CPNE1 copine I 0.0274284
UTRN utrophin 0.0272494
EXOC4 exocyst complex component 4 0.0268637
NUMA1 nuclear mitotic apparatus protein 1 0.0267411
PRSS23 protease, serine, 23 0.0265122
ATXN1 ataxin 1 0.0263065
NONO non-POU domain containing, octamer-binding 0.0263022
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0263014
LAMC2 laminin, gamma 2 0.0258571
TRIO trio Rho guanine nucleotide exchange factor 0.0258017
RABGAP1L RAB GTPase activating protein 1-like 0.0256392
RPL3 ribosomal protein L3 0.0255038
DIDO1 death inducer-obliterator 1 0.0254769
ANXA11 annexin A11 0.0254599
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0254224
SEPTIN9 septin 9 0.0251791
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0250874
CNTNAP3 contactin associated protein-like 3 0.0248913
FOXO1 forkhead box O1 0.0248271
CLIC4 chloride intracellular channel 4 0.0247518
TNS3 tensin 3 0.0247182
EGFR epidermal growth factor receptor 0.0246588
LMO7 LIM domain 7 0.024609
LUZP1 leucine zipper protein 1 0.0243071
ARHGAP23 Rho GTPase activating protein 23 0.0240216
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0236738
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0236433
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231612
ACTN1 actinin, alpha 1 0.0231186
ZMIZ1 zinc finger, MIZ-type containing 1 0.0231052
APP amyloid beta (A4) precursor protein 0.0230099
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.022573
THSD4 thrombospondin, type I, domain containing 4 0.0223358
SLC45A4 solute carrier family 45, member 4 0.0223209
HMGA2 high mobility group AT-hook 2 0.0222718
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0221777
MECOM MDS1 and EVI1 complex locus 0.0220692

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.29017
PTMA prothymosin, alpha -0.12295
S100A10 S100 calcium binding protein A10 -0.0993813
TMSB10 thymosin beta 10 -0.0937841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0913182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0839262
RPS21 ribosomal protein S21 -0.0752717
GNAS GNAS complex locus -0.0707213
EMP1 epithelial membrane protein 1 -0.0674947
GOLGA4 golgin A4 -0.0665211
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0652262
ANXA1 annexin A1 -0.0651717
TPT1 tumor protein, translationally-controlled 1 -0.0632063
NDRG1 N-myc downstream regulated 1 -0.0625001
H1-0 H1.0 linker histone -0.059898
SQLE squalene epoxidase -0.0596049
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0594268
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0554271
ANXA2 annexin A2 -0.0548849
ENO1 enolase 1, (alpha) -0.0534103
NAMPT nicotinamide phosphoribosyltransferase -0.05333
RPS8 ribosomal protein S8 -0.0515315
MEF2A myocyte enhancer factor 2A -0.0489358
LMNA lamin A/C -0.0485244
RPLP2 ribosomal protein, large, P2 -0.0485143
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0483846
S100A6 S100 calcium binding protein A6 -0.0467118
WASF2 WAS protein family, member 2 -0.0465792
RPS13 ribosomal protein S13 -0.0461352
RPLP1 ribosomal protein, large, P1 -0.0461077
RPL8 ribosomal protein L8 -0.045878
LDHA lactate dehydrogenase A -0.0453582
CAV1 caveolin 1, caveolae protein, 22kDa -0.0448119
CANX calnexin -0.0445019
RPS6 ribosomal protein S6 -0.0436868
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.04346
PGK1 phosphoglycerate kinase 1 -0.0431008
STC1 stanniocalcin 1 -0.0428544
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0428447
S100A9 S100 calcium binding protein A9 -0.0417672
LMAN1 lectin, mannose-binding, 1 -0.0416018
S100A2 S100 calcium binding protein A2 -0.0415787
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0401513
IGF2 insulin-like growth factor 2 -0.0394074
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0393278
RPL12 ribosomal protein L12 -0.0391218
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0383144
VDAC1 voltage-dependent anion channel 1 -0.0381758
MORF4L2 mortality factor 4 like 2 -0.0381726
DSTN destrin (actin depolymerizing factor) -0.0379053
RPS24 ribosomal protein S24 -0.037829
KRT17 keratin 17, type I -0.0368633
IFITM3 interferon induced transmembrane protein 3 -0.0364055
FTL ferritin, light polypeptide -0.0360566
MT1X metallothionein 1X -0.0353376
RPL34 ribosomal protein L34 -0.0346655
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0346507
RPS25 ribosomal protein S25 -0.0344454
FSCN1 fascin actin-bundling protein 1 -0.0341865
COPB1 coatomer protein complex, subunit beta 1 -0.0340018
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.033266
RPLP0 ribosomal protein, large, P0 -0.0329026
PDIA3 protein disulfide isomerase family A, member 3 -0.0327632
SEC31A SEC31 homolog A (S. cerevisiae) -0.0326185
PKM pyruvate kinase, muscle -0.032046
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0319502
RPS19 ribosomal protein S19 -0.0317914
SRP54 signal recognition particle 54kDa -0.0315629
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0315524
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0310437
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0309139
S100A11 S100 calcium binding protein A11 -0.0308104
GARS1 glycyl-tRNA synthetase 1 -0.0306784
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0302831
KDM3A lysine (K)-specific demethylase 3A -0.0302038
RPL32 ribosomal protein L32 -0.0299037
ANLN anillin, actin binding protein -0.0297429
SPAG9 sperm associated antigen 9 -0.0296872
CALU calumenin -0.0296457
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0295298
RPL11 ribosomal protein L11 -0.0287303
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0280541
RAB1A RAB1A, member RAS oncogene family -0.0279422
EZR ezrin -0.0278619
RPL27A ribosomal protein L27a -0.0276898
STAU1 staufen double-stranded RNA binding protein 1 -0.0275373
KDM5B lysine (K)-specific demethylase 5B -0.0273699
UFM1 ubiquitin-fold modifier 1 -0.0273491
CD44 CD44 molecule (Indian blood group) -0.0271476
MXI1 MAX interactor 1, dimerization protein -0.0271185
IER3 immediate early response 3 -0.0270793
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.026785
RAB2A RAB2A, member RAS oncogene family -0.0267779
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.026707
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0264801
TM4SF1 transmembrane 4 L six family member 1 -0.0263967
TAGLN2 transgelin 2 -0.0261436
RLF rearranged L-myc fusion -0.0258074
RPL35A ribosomal protein L35a -0.025672
RIOK3 RIO kinase 3 -0.0256527