DTP3_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.133523
SMAD3 SMAD family member 3 0.0959963
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0878246
FAM20C family with sequence similarity 20, member C 0.0751461
TRIO trio Rho guanine nucleotide exchange factor 0.0676633
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0644863
RBM39 RNA binding motif protein 39 0.0613491
SOD2 superoxide dismutase 2, mitochondrial 0.0552321
PRELID2 PRELI domain containing 2 0.0525994
MYH9 myosin, heavy chain 9, non-muscle 0.0516749
FAM13A family with sequence similarity 13, member A 0.0482904
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.048253
NAV2 neuron navigator 2 0.0466541
AKAP12 A kinase (PRKA) anchor protein 12 0.0453011
KDM3A lysine (K)-specific demethylase 3A 0.0448711
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0406874
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0403713
EEF2 eukaryotic translation elongation factor 2 0.0385411
APP amyloid beta (A4) precursor protein 0.0385008
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0366995
OGA O-GlcNAcase 0.0364331
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0356869
TNIP1 TNFAIP3 interacting protein 1 0.0356133
CNOT12 CCR4-NOT transcription complex subunit 12 0.0346942
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0340221
DOCK5 dedicator of cytokinesis 5 0.0339552
VEGFA vascular endothelial growth factor A 0.0336966
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0329549
CEP250 centrosomal protein 250kDa 0.0325546
ELL2 elongation factor, RNA polymerase II, 2 0.0313976
MAP2K1 mitogen-activated protein kinase kinase 1 0.0306649
FNDC3B fibronectin type III domain containing 3B 0.0305684
RUNX1 runt-related transcription factor 1 0.0300956
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0295512
AMPD3 adenosine monophosphate deaminase 3 0.0294191
PFKP phosphofructokinase, platelet 0.0283192
KDM2A lysine (K)-specific demethylase 2A 0.028165
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0275541
ANKRD11 ankyrin repeat domain 11 0.0265797
KANSL1 KAT8 regulatory NSL complex subunit 1 0.026417
CTNND1 catenin (cadherin-associated protein), delta 1 0.0254679
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0242805
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0242756
ANKRD36 ankyrin repeat domain 36 0.0238505
PCBP2 poly(rC) binding protein 2 0.0235809
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0235142
YEATS2 YEATS domain containing 2 0.0235114
GRB10 growth factor receptor-bound protein 10 0.0234811
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0227434
ZNF292 zinc finger protein 292 0.0225958
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0223592
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0223152
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0221832
UBE2O ubiquitin-conjugating enzyme E2O 0.0217168
SUN1 Sad1 and UNC84 domain containing 1 0.0213937
CCNY cyclin Y 0.0210139
MLPH melanophilin 0.020947
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0204499
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0202289
CPNE1 copine I 0.020054
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0200108
RPL3 ribosomal protein L3 0.0199774
SIK3 SIK family kinase 3 0.019794
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0192514
FLNB filamin B, beta 0.0190646
DSCAM Down syndrome cell adhesion molecule 0.0188587
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.018808
CABIN1 calcineurin binding protein 1 0.018744
TMSB4X thymosin beta 4, X-linked 0.0186828
INTS1 integrator complex subunit 1 0.0186533
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0186163
ARHGAP5 Rho GTPase activating protein 5 0.018509
BACE2 beta-site APP-cleaving enzyme 2 0.0184696
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0184342
DPYSL3 dihydropyrimidinase-like 3 0.0182736
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0182721
SRRM2 serine/arginine repetitive matrix 2 0.0182499
ZNF638 zinc finger protein 638 0.0182199
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0181996
RAB27B RAB27B, member RAS oncogene family 0.0181798
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0180511
FMNL2 formin-like 2 0.0179897
USP34 ubiquitin specific peptidase 34 0.0179841
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.017964
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0179046
ESYT2 extended synaptotagmin-like protein 2 0.0178265
NGLY1 N-glycanase 1 0.0177463
IGF1R insulin-like growth factor 1 receptor 0.0175919
NBAS neuroblastoma amplified sequence 0.0175854
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0175021
BASP1 brain abundant, membrane attached signal protein 1 0.0174382
ETV6 ets variant 6 0.0173757
BHLHE40 basic helix-loop-helix family, member e40 0.0173668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0172047
ATP13A3 ATPase type 13A3 0.0171943
AHNAK AHNAK nucleoprotein 0.0171655
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0170583
DIDO1 death inducer-obliterator 1 0.0170435
ZFAND3 zinc finger, AN1-type domain 3 0.0170202
TGM2 transglutaminase 2 0.0167623

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194652
VIM vimentin -0.100012
FN1 fibronectin 1 -0.0718026
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0622321
LOX lysyl oxidase -0.0621155
TMSB10 thymosin beta 10 -0.0592505
FTL ferritin, light polypeptide -0.0533377
GLCCI1 glucocorticoid induced 1 -0.0510018
HMGA1 high mobility group AT-hook 1 -0.0453818
CDH13 cadherin 13 -0.0440791
HMGA2 high mobility group AT-hook 2 -0.0438811
EGR1 early growth response 1 -0.0397077
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0392414
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0377371
NRG1 neuregulin 1 -0.035925
DPYD dihydropyrimidine dehydrogenase -0.0352022
RPL31 ribosomal protein L31 -0.0292552
MT2A metallothionein 2A -0.0287926
RPS12 ribosomal protein S12 -0.0273947
RPL37A ribosomal protein L37a -0.0272764
RPLP1 ribosomal protein, large, P1 -0.0272232
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.026841
NTN4 netrin 4 -0.026822
FTH1 ferritin, heavy polypeptide 1 -0.0262743
RPS19 ribosomal protein S19 -0.0252406
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0252262
MEF2A myocyte enhancer factor 2A -0.0248695
RPL35A ribosomal protein L35a -0.0241462
RPS29 ribosomal protein S29 -0.0237448
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0224173
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0223609
RPS8 ribosomal protein S8 -0.0222251
AADAC arylacetamide deacetylase -0.0219824
TFPI2 tissue factor pathway inhibitor 2 -0.0217141
RPL36 ribosomal protein L36 -0.0215353
LOC102724023 ES1 protein homolog, mitochondrial -0.0214606
RPS6 ribosomal protein S6 -0.0212235
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.020852
DDIT3 DNA-damage-inducible transcript 3 -0.0207159
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0205836
ENO1 enolase 1, (alpha) -0.0201244
ENO2 enolase 2 (gamma, neuronal) -0.0201191
POTEF POTE ankyrin domain family, member F -0.0200163
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0199623
IFI6 interferon, alpha-inducible protein 6 -0.0192311
PSD3 pleckstrin and Sec7 domain containing 3 -0.0191441
RAI14 retinoic acid induced 14 -0.0182016
RASAL2 RAS protein activator like 2 -0.018171
FBXO11 F-box protein 11 -0.0180807
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.017874
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0176405
IER3 immediate early response 3 -0.0175431
IL1B interleukin 1, beta -0.0174661
RPS11 ribosomal protein S11 -0.0174055
RPL32 ribosomal protein L32 -0.0169979
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0168395
SLC38A2 solute carrier family 38, member 2 -0.0167479
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0166103
RPS3 ribosomal protein S3 -0.0164482
RPL28 ribosomal protein L28 -0.016418
VCL vinculin -0.0163967
TPT1 tumor protein, translationally-controlled 1 -0.0162485
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0162166
RPL34 ribosomal protein L34 -0.0158015
NDRG1 N-myc downstream regulated 1 -0.0155537
IFITM3 interferon induced transmembrane protein 3 -0.0154033
BTG1 B-cell translocation gene 1, anti-proliferative -0.0151586
MAP1B microtubule-associated protein 1B -0.0150221
RPS23 ribosomal protein S23 -0.0149727
WLS wntless Wnt ligand secretion mediator -0.0148924
SOS1 son of sevenless homolog 1 (Drosophila) -0.0147843
MSRB3 methionine sulfoxide reductase B3 -0.0147723
RACK1 receptor for activated C kinase 1 -0.0146006
NAP1L1 nucleosome assembly protein 1-like 1 -0.0145826
PDE4D phosphodiesterase 4D, cAMP-specific -0.0145508
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.0145151
RAB7A RAB7A, member RAS oncogene family -0.0143945
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0143729
B2M beta-2-microglobulin -0.014323
ZNF804A zinc finger protein 804A -0.0143132
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142806
MYADM myeloid-associated differentiation marker -0.014172
RPS25 ribosomal protein S25 -0.0140832
TIMP3 TIMP metallopeptidase inhibitor 3 -0.01399
RPLP2 ribosomal protein, large, P2 -0.0138839
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.013478
CLMP CXADR-like membrane protein -0.0133454
OXR1 oxidation resistance 1 -0.0132938
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0132868
TMEM165 transmembrane protein 165 -0.0132849
RAP1B RAP1B, member of RAS oncogene family -0.0132722
GNAS GNAS complex locus -0.0132651
BLZF1 basic leucine zipper nuclear factor 1 -0.0129793
RPL9 ribosomal protein L9 -0.0128354
TM4SF1 transmembrane 4 L six family member 1 -0.0127592
RPS5 ribosomal protein S5 -0.0127505
SYT1 synaptotagmin I -0.0126119
RPS27 ribosomal protein S27 -0.0125878
PDLIM5 PDZ and LIM domain 5 -0.0125617
IFI27 interferon, alpha-inducible protein 27 -0.0125591