DTP3_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0768583
THSD4 thrombospondin, type I, domain containing 4 0.0677843
RPL37A ribosomal protein L37a 0.0620357
RPS3 ribosomal protein S3 0.0599783
RPS12 ribosomal protein S12 0.0523418
RPL35A ribosomal protein L35a 0.0515301
PLEC plectin 0.0484476
RPL37 ribosomal protein L37 0.0483523
AKAP12 A kinase (PRKA) anchor protein 12 0.0479906
GRAMD1B GRAM domain containing 1B 0.0432444
SMAD3 SMAD family member 3 0.0428022
RPS6 ribosomal protein S6 0.0388223
EEF2 eukaryotic translation elongation factor 2 0.0360002
HLA-B major histocompatibility complex, class I, B 0.0350815
SRRM2 serine/arginine repetitive matrix 2 0.0343228
RPL11 ribosomal protein L11 0.0338383
IFI6 interferon, alpha-inducible protein 6 0.0329806
RPS27 ribosomal protein S27 0.0324134
TXNRD1 thioredoxin reductase 1 0.0303414
PTPRF protein tyrosine phosphatase, receptor type, F 0.0302383
KMT2D lysine (K)-specific methyltransferase 2D 0.0294532
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0287481
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0284591
MYH9 myosin, heavy chain 9, non-muscle 0.0276483
NONO non-POU domain containing, octamer-binding 0.0270985
RPL31 ribosomal protein L31 0.0269507
DCAF8 DDB1 and CUL4 associated factor 8 0.026809
ARID1A AT rich interactive domain 1A (SWI-like) 0.0261282
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0253603
RPL36 ribosomal protein L36 0.0250938
RPS19 ribosomal protein S19 0.0250807
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0248672
SENP6 SUMO1/sentrin specific peptidase 6 0.0246134
ACTN1 actinin, alpha 1 0.0245736
RNF213 ring finger protein 213 0.0242278
RPL3 ribosomal protein L3 0.0242056
RPS17 ribosomal protein S17 0.0241511
DIDO1 death inducer-obliterator 1 0.0236358
PFKP phosphofructokinase, platelet 0.0235838
HSPA8 heat shock 70kDa protein 8 0.0233577
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.023285
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0232366
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0228944
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225138
NUMA1 nuclear mitotic apparatus protein 1 0.0222813
SHB Src homology 2 domain containing adaptor protein B 0.0218624
CEP250 centrosomal protein 250kDa 0.0211732
IQGAP3 IQ motif containing GTPase activating protein 3 0.0207577
KRT18 keratin 18, type I 0.0206704
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0204333
RPL9 ribosomal protein L9 0.0202215
RLIM ring finger protein, LIM domain interacting 0.020137
PRRC2A proline-rich coiled-coil 2A 0.0201231
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0200451
SQSTM1 sequestosome 1 0.0198516
NCOR2 nuclear receptor corepressor 2 0.0196152
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.01954
MINK1 misshapen-like kinase 1 0.0193133
CALD1 caldesmon 1 0.0188594
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0184988
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.0182894
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.018174
RPL13A ribosomal protein L13a 0.018122
YBX3 Y box binding protein 3 0.0180857
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0175796
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.017427
PRELID3B PRELI domain containing 3B 0.0171922
WDR43 WD repeat domain 43 0.0168322
INTS1 integrator complex subunit 1 0.0168268
GOLGA3 golgin A3 0.0166963
AATF apoptosis antagonizing transcription factor 0.0165569
GSE1 Gse1 coiled-coil protein 0.0164741
HMGA2 high mobility group AT-hook 2 0.0164214
FLNA filamin A, alpha 0.0163324
CTSL cathepsin L 0.0163015
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0162586
MKRN1 makorin ring finger protein 1 0.0160445
ATP11A ATPase, class VI, type 11A 0.015969
POTEF POTE ankyrin domain family, member F 0.015669
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0156215
TJP1 tight junction protein 1 0.0156064
PTK2 protein tyrosine kinase 2 0.0152284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0152174
HMOX1 heme oxygenase 1 0.0151567
UBQLN4 ubiquilin 4 0.0151024
HLA-A major histocompatibility complex, class I, A 0.0150331
MPRIP myosin phosphatase Rho interacting protein 0.0149924
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.014925
MIDEAS mitotic deacetylase associated SANT domain protein 0.0147727
PNN pinin, desmosome associated protein 0.0146602
LSM12 LSM12 homolog (S. cerevisiae) 0.0145809
IGF1R insulin-like growth factor 1 receptor 0.0145754
DCTN1 dynactin 1 0.0144731
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.014469
CMIP c-Maf inducing protein 0.0144505
ACIN1 apoptotic chromatin condensation inducer 1 0.0144039
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0143888
SON SON DNA binding protein 0.0143818
KPNB1 karyopherin (importin) beta 1 0.0143157
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0141977

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.454195
UBC ubiquitin C -0.140893
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.138716
TFPI2 tissue factor pathway inhibitor 2 -0.115263
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0953728
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0767594
PDE4D phosphodiesterase 4D, cAMP-specific -0.073165
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0705863
NIPBL Nipped-B homolog (Drosophila) -0.0625459
VIM vimentin -0.0618643
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0604735
TM4SF1 transmembrane 4 L six family member 1 -0.0578694
RPS27A ribosomal protein S27a -0.0576971
EIF4A1 eukaryotic translation initiation factor 4A1 -0.055378
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.051751
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0506926
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0506279
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0487209
ENO1 enolase 1, (alpha) -0.0483371
CANX calnexin -0.0453181
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0448773
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0442818
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0440648
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0428865
MCL1 myeloid cell leukemia 1 -0.0423999
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0421215
PTMA prothymosin, alpha -0.0420554
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.040646
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.039919
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0395688
AHNAK AHNAK nucleoprotein -0.0386192
PCBP2 poly(rC) binding protein 2 -0.0378118
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0364425
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0363453
PDIA3 protein disulfide isomerase family A, member 3 -0.0358802
RPS21 ribosomal protein S21 -0.0351511
CCND2 cyclin D2 -0.0345119
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0343991
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0333924
KDM2A lysine (K)-specific demethylase 2A -0.0332041
PDIA4 protein disulfide isomerase family A, member 4 -0.0324912
PDIA6 protein disulfide isomerase family A, member 6 -0.032063
GNAS GNAS complex locus -0.0319099
CSDE1 cold shock domain containing E1, RNA-binding -0.031522
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314904
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0312364
ZNF207 zinc finger protein 207 -0.0304472
RPL23 ribosomal protein L23 -0.0294726
RRM2 ribonucleotide reductase M2 -0.0292003
SRP72 signal recognition particle 72kDa -0.0291446
STAU1 staufen double-stranded RNA binding protein 1 -0.0289829
SRRM1 serine/arginine repetitive matrix 1 -0.0289338
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0286957
NF1 neurofibromin 1 -0.0286667
SMC4 structural maintenance of chromosomes 4 -0.0286155
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0283154
RAB1A RAB1A, member RAS oncogene family -0.0282105
RAB7A RAB7A, member RAS oncogene family -0.0280617
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0277316
H1-0 H1.0 linker histone -0.0276077
TPX2 TPX2, microtubule-associated -0.0272001
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0268105
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0265817
PRELID2 PRELI domain containing 2 -0.0263522
PREPL prolyl endopeptidase-like -0.0259734
TUBA1B tubulin, alpha 1b -0.0257936
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0256936
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0256359
GOLGA4 golgin A4 -0.0253907
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0251485
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0251426
PKM pyruvate kinase, muscle -0.0246173
LMAN1 lectin, mannose-binding, 1 -0.0243903
OSMR oncostatin M receptor -0.0242719
RHOA ras homolog family member A -0.0241712
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0239746
ZNF638 zinc finger protein 638 -0.023859
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.023522
SPDYA speedy/RINGO cell cycle regulator family member A -0.0234181
MBD5 methyl-CpG binding domain protein 5 -0.0234176
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0232915
SCAF11 SR-related CTD-associated factor 11 -0.0232526
VCP valosin containing protein -0.023161
S100A10 S100 calcium binding protein A10 -0.0230554
GPHN gephyrin -0.0229592
WDPCP WD repeat containing planar cell polarity effector -0.0229454
CCND1 cyclin D1 -0.0229193
KMT2A lysine (K)-specific methyltransferase 2A -0.0226916
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0226693
TOP1 topoisomerase (DNA) I -0.0224979
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0222953
CDK12 cyclin-dependent kinase 12 -0.022014
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0219371
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0219075
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0216671
JMJD1C jumonji domain containing 1C -0.0215874
HDAC8 histone deacetylase 8 -0.0215354
PDE10A phosphodiesterase 10A -0.0214813
DEK DEK proto-oncogene -0.0213033
WASF2 WAS protein family, member 2 -0.0212347