DTP3_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.232755
POTEF POTE ankyrin domain family, member F 0.136865
MYH9 myosin, heavy chain 9, non-muscle 0.130094
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.127726
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.127528
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0991631
NDRG1 N-myc downstream regulated 1 0.0930953
PLEC plectin 0.0841589
APLP2 amyloid beta (A4) precursor-like protein 2 0.0783155
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0747834
NAV2 neuron navigator 2 0.0742165
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0737532
VEGFA vascular endothelial growth factor A 0.0663649
HSPA8 heat shock 70kDa protein 8 0.0648699
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0640294
EEF2 eukaryotic translation elongation factor 2 0.0605916
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0602635
TPM3 tropomyosin 3 0.0587169
MSN moesin 0.0580329
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0572788
GRB10 growth factor receptor-bound protein 10 0.0555004
DSPP dentin sialophosphoprotein 0.0518642
SAMD4A sterile alpha motif domain containing 4A 0.0482708
ASPH aspartate beta-hydroxylase 0.0482589
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0449091
AHNAK AHNAK nucleoprotein 0.0444734
RPL3 ribosomal protein L3 0.042566
SQSTM1 sequestosome 1 0.0416728
TNIP1 TNFAIP3 interacting protein 1 0.041558
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0404321
CALR calreticulin 0.0401865
TRIO trio Rho guanine nucleotide exchange factor 0.0397532
FHIT fragile histidine triad 0.0390323
KRT8 keratin 8, type II 0.0385577
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0380009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.037909
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0378236
SET SET nuclear proto-oncogene 0.0376883
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0365587
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0357023
MACF1 microtubule-actin crosslinking factor 1 0.0355403
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0354102
BRD2 bromodomain containing 2 0.0351718
ARRDC3 arrestin domain containing 3 0.0345515
SMAD3 SMAD family member 3 0.0344377
LAMB3 laminin, beta 3 0.0341647
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0341617
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0337632
ENO1 enolase 1, (alpha) 0.0334286
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0331854
HDGF hepatoma-derived growth factor 0.0324586
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0314218
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0311122
PRRC2C proline-rich coiled-coil 2C 0.0303495
PCBP2 poly(rC) binding protein 2 0.0294296
NONO non-POU domain containing, octamer-binding 0.029382
FLNB filamin B, beta 0.0291591
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290521
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0285974
SFPQ splicing factor proline/glutamine-rich 0.0280679
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0270309
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0270067
ZSWIM6 zinc finger, SWIM-type containing 6 0.0268572
KTN1 kinectin 1 (kinesin receptor) 0.0268042
SRRM2 serine/arginine repetitive matrix 2 0.0267193
STAT1 signal transducer and activator of transcription 1, 91kDa 0.026615
MX1 MX dynamin-like GTPase 1 0.0265309
MYO5B myosin VB 0.0264062
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0261226
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0260851
PKM pyruvate kinase, muscle 0.0259311
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0258676
KIAA1217 KIAA1217 0.0255894
SMYD3 SET and MYND domain containing 3 0.0255037
EXT1 exostosin glycosyltransferase 1 0.0253173
ERRFI1 ERBB receptor feedback inhibitor 1 0.0250156
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0246778
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0244463
AKAP13 A kinase (PRKA) anchor protein 13 0.0244086
ANXA11 annexin A11 0.024375
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0239085
FNDC3B fibronectin type III domain containing 3B 0.0237831
MCL1 myeloid cell leukemia 1 0.0237328
CCNB1 cyclin B1 0.0236774
IRF6 interferon regulatory factor 6 0.0235404
TMF1 TATA element modulatory factor 1 0.0234303
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0232669
RSRC2 arginine/serine-rich coiled-coil 2 0.0229754
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0225886
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0220062
RCOR1 REST corepressor 1 0.0219723
MORF4L2 mortality factor 4 like 2 0.0218561
NUMA1 nuclear mitotic apparatus protein 1 0.0217488
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.021572
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0213101
FXR1 fragile X mental retardation, autosomal homolog 1 0.0211639
INTS6 integrator complex subunit 6 0.0211457
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0209999
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0209743
PPARD peroxisome proliferator-activated receptor delta 0.0209257

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.270381
FN1 fibronectin 1 -0.15018
TMSB10 thymosin beta 10 -0.120517
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110632
FTL ferritin, light polypeptide -0.0948127
ACTG1 actin gamma 1 -0.0915032
TPT1 tumor protein, translationally-controlled 1 -0.0880018
TM4SF1 transmembrane 4 L six family member 1 -0.0854808
S100A6 S100 calcium binding protein A6 -0.08031
RPL34 ribosomal protein L34 -0.0799069
RPL35A ribosomal protein L35a -0.0723923
S100A10 S100 calcium binding protein A10 -0.0705903
LMO7 LIM domain 7 -0.0650269
PTMA prothymosin, alpha -0.0633416
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0618084
RPL8 ribosomal protein L8 -0.0514951
CCND1 cyclin D1 -0.0485375
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0478809
RPS23 ribosomal protein S23 -0.0477647
GNAS GNAS complex locus -0.046468
FTH1 ferritin, heavy polypeptide 1 -0.0460365
RPLP1 ribosomal protein, large, P1 -0.0451698
TMEM263 transmembrane protein 263 -0.0427004
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0399308
ARF1 ADP-ribosylation factor 1 -0.0396833
SOX4 SRY (sex determining region Y)-box 4 -0.0389938
MDK midkine (neurite growth-promoting factor 2) -0.0386643
RPLP2 ribosomal protein, large, P2 -0.0384373
CD2AP CD2-associated protein -0.0376814
RAB1A RAB1A, member RAS oncogene family -0.0371111
NAMPT nicotinamide phosphoribosyltransferase -0.0367179
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0366872
HMGA1 high mobility group AT-hook 1 -0.0363982
TMEM165 transmembrane protein 165 -0.0363157
NPEPPS aminopeptidase puromycin sensitive -0.0359823
RPL32 ribosomal protein L32 -0.035939
CSTB cystatin B (stefin B) -0.0349472
IFI6 interferon, alpha-inducible protein 6 -0.0345701
RPS8 ribosomal protein S8 -0.0343937
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0343629
STRN3 striatin, calmodulin binding protein 3 -0.0339372
SLC38A1 solute carrier family 38, member 1 -0.0335164
ANXA2 annexin A2 -0.0326477
RPS13 ribosomal protein S13 -0.0326042
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0322678
RPS29 ribosomal protein S29 -0.0318245
RPS16 ribosomal protein S16 -0.031677
MAP4 microtubule-associated protein 4 -0.0315793
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0311277
KMT2E lysine (K)-specific methyltransferase 2E -0.0305236
ALCAM activated leukocyte cell adhesion molecule -0.0302585
RPS27A ribosomal protein S27a -0.0301769
FAM3C family with sequence similarity 3, member C -0.0300507
IFITM1 interferon induced transmembrane protein 1 -0.0292404
RPS21 ribosomal protein S21 -0.0287004
MARCHF6 membrane associated ring-CH-type finger 6 -0.0282818
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0281965
CRABP2 cellular retinoic acid binding protein 2 -0.0281799
RPL12 ribosomal protein L12 -0.0281331
RPS25 ribosomal protein S25 -0.0278332
RPS19 ribosomal protein S19 -0.0276259
KDM5B lysine (K)-specific demethylase 5B -0.0275001
IFI27 interferon, alpha-inducible protein 27 -0.0274955
F3 coagulation factor III (thromboplastin, tissue factor) -0.0269362
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0266592
RPL19 ribosomal protein L19 -0.0262489
RPL27A ribosomal protein L27a -0.026227
TMEM123 transmembrane protein 123 -0.0262027
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.026116
RPS14 ribosomal protein S14 -0.0259727
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259425
UBC ubiquitin C -0.0255076
OSMR oncostatin M receptor -0.0254484
HSPB1 heat shock 27kDa protein 1 -0.0253768
BASP1 brain abundant, membrane attached signal protein 1 -0.0253635
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0252877
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0251872
RTN4 reticulon 4 -0.0249703
LY6E lymphocyte antigen 6 complex, locus E -0.0247894
RPL23 ribosomal protein L23 -0.0246298
S100A9 S100 calcium binding protein A9 -0.0244691
RHOA ras homolog family member A -0.0243134
RPL11 ribosomal protein L11 -0.0242093
CAPN2 calpain 2, (m/II) large subunit -0.0241946
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.024176
CTSB cathepsin B -0.024107
LMAN1 lectin, mannose-binding, 1 -0.0240513
ZFAND6 zinc finger, AN1-type domain 6 -0.023792
RPL30 ribosomal protein L30 -0.0237599
RPS5 ribosomal protein S5 -0.0234416
RACK1 receptor for activated C kinase 1 -0.023171
C15ORF48 chromosome 15 open reading frame 48 -0.0230648
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0228389
IFITM3 interferon induced transmembrane protein 3 -0.0226517
RPL28 ribosomal protein L28 -0.0226288
CTSD cathepsin D -0.022545
PRRC1 proline-rich coiled-coil 1 -0.0222363
CDK17 cyclin-dependent kinase 17 -0.0221808
LIMCH1 LIM and calponin homology domains 1 -0.0221148
RPS24 ribosomal protein S24 -0.0220448