DTP3_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

76 genes differentially expressed following the DTP3_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.277207
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.196396
RBM39 RNA binding motif protein 39 0.18881
DSCAM Down syndrome cell adhesion molecule 0.176314
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.135422
AKAP12 A kinase (PRKA) anchor protein 12 0.117269
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.111496
PRRC2C proline-rich coiled-coil 2C 0.107679
FNDC3B fibronectin type III domain containing 3B 0.102408
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0937653
RPS8 ribosomal protein S8 0.0906714
PDE10A phosphodiesterase 10A 0.0901111
HMGA2 high mobility group AT-hook 2 0.0888724
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.08638
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0831911
NDRG1 N-myc downstream regulated 1 0.0815586
ZFAND3 zinc finger, AN1-type domain 3 0.0784598
RORA RAR-related orphan receptor A 0.0714688
LMO7 LIM domain 7 0.065495
RPS16 ribosomal protein S16 0.0613081
TPT1 tumor protein, translationally-controlled 1 0.0567319
ENO1 enolase 1, (alpha) 0.0509403
GPC6 glypican 6 0.0508151
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0459941
RPS23 ribosomal protein S23 0.0408674
POTEF POTE ankyrin domain family, member F 0.0399253
TRIO trio Rho guanine nucleotide exchange factor 0.0371291
IER3 immediate early response 3 0.0362298
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0338866
RPLP2 ribosomal protein, large, P2 0.0329834
RPS6 ribosomal protein S6 0.0269143
DST dystonin 0.0215984
EGFR epidermal growth factor receptor 0.0202432
RPL19 ribosomal protein L19 0.0190605
ASPH aspartate beta-hydroxylase 0.0144183
RPS27A ribosomal protein S27a 0.0103321
RPL31 ribosomal protein L31 0.00774579
RPLP0 ribosomal protein, large, P0 0.0073506
RPLP1 ribosomal protein, large, P1 0.00164551

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.315814
PTMA prothymosin, alpha -0.238765
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.163543
FN1 fibronectin 1 -0.153153
VIM vimentin -0.115034
IGF2 insulin-like growth factor 2 -0.110537
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.10842
CADM2 cell adhesion molecule 2 -0.0893427
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0852061
PEG10 paternally expressed 10 -0.0769996
ZBTB20 zinc finger and BTB domain containing 20 -0.0596939
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0569308
SMYD3 SET and MYND domain containing 3 -0.0555706
UBC ubiquitin C -0.0520056
ACTN4 actinin, alpha 4 -0.0497651
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.048639
RPL37A ribosomal protein L37a -0.0468805
PGK1 phosphoglycerate kinase 1 -0.0455558
EXT1 exostosin glycosyltransferase 1 -0.0448034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0413466
PRKCA protein kinase C, alpha -0.0305231
LDHA lactate dehydrogenase A -0.0293074
TMSB10 thymosin beta 10 -0.0283783
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0247782
RTN4 reticulon 4 -0.0247467
ANXA2 annexin A2 -0.024545
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0242938
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0237914
RPS3 ribosomal protein S3 -0.0229547
CD44 CD44 molecule (Indian blood group) -0.0218487
EIF1 eukaryotic translation initiation factor 1 -0.0190395
RPL23 ribosomal protein L23 -0.0125378
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00675791
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.00475877
NUP58 nucleoporin 58 -0.00371712
RPS12 ribosomal protein S12 -9.70343E-4
VCL vinculin -6.24799E-4