DTP3_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.15388
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.126562
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.110889
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.105261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0983262
APP amyloid beta (A4) precursor protein 0.0858335
TMSB4X thymosin beta 4, X-linked 0.0808627
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0787586
ANKRD33B ankyrin repeat domain 33B 0.0774253
SRRM2 serine/arginine repetitive matrix 2 0.0755037
MACF1 microtubule-actin crosslinking factor 1 0.0754165
HDAC9 histone deacetylase 9 0.0733471
ZFAND3 zinc finger, AN1-type domain 3 0.0695155
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0685169
PUM1 pumilio RNA-binding family member 1 0.0682585
RBM39 RNA binding motif protein 39 0.0678226
NONO non-POU domain containing, octamer-binding 0.0659483
KDM3A lysine (K)-specific demethylase 3A 0.0659109
EEF2 eukaryotic translation elongation factor 2 0.0628493
TENM3 teneurin transmembrane protein 3 0.062487
CALR calreticulin 0.0612639
RAD21 RAD21 homolog (S. pombe) 0.0593959
JMJD1C jumonji domain containing 1C 0.0586442
PRTG protogenin 0.0542388
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0534352
KMT2C lysine (K)-specific methyltransferase 2C 0.0516009
MYH9 myosin, heavy chain 9, non-muscle 0.0510233
ENAH enabled homolog (Drosophila) 0.0506988
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0502306
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0501806
STRN3 striatin, calmodulin binding protein 3 0.0493679
PRRC2C proline-rich coiled-coil 2C 0.0487688
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0476211
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0474922
NOP58 NOP58 ribonucleoprotein 0.0473527
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0473084
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0468146
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0467057
RPL3 ribosomal protein L3 0.0456044
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0449021
ANKRD11 ankyrin repeat domain 11 0.0446962
FNDC3B fibronectin type III domain containing 3B 0.0446778
NCKAP1 NCK-associated protein 1 0.0436241
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0429474
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0426325
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0425617
PDGFC platelet derived growth factor C 0.0412744
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0410319
ZNF608 zinc finger protein 608 0.0409577
ZEB2 zinc finger E-box binding homeobox 2 0.0407577
WAC WW domain containing adaptor with coiled-coil 0.0407103
USP25 ubiquitin specific peptidase 25 0.0405959
TRA2A transformer 2 alpha homolog (Drosophila) 0.0405573
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0404964
ZNF292 zinc finger protein 292 0.0403928
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0402845
RBM33 RNA binding motif protein 33 0.0401539
PRKD1 protein kinase D1 0.0399741
DST dystonin 0.0399638
CDH10 cadherin 10, type 2 (T2-cadherin) 0.039949
TRIO trio Rho guanine nucleotide exchange factor 0.0391379
TNRC6B trinucleotide repeat containing 6B 0.0391036
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0384838
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0384266
KIF5B kinesin family member 5B 0.038409
CLTC clathrin, heavy chain (Hc) 0.0383126
SAMD4A sterile alpha motif domain containing 4A 0.0383007
RSRC2 arginine/serine-rich coiled-coil 2 0.0370689
COL5A2 collagen, type V, alpha 2 0.0369227
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0366246
KMT2E lysine (K)-specific methyltransferase 2E 0.0366197
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0365507
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0362579
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0362279
XPO1 exportin 1 0.0361529
MATR3 matrin 3 0.0361178
CSNK1A1 casein kinase 1, alpha 1 0.0360178
SIK3 SIK family kinase 3 0.0358039
AKAP9 A kinase (PRKA) anchor protein 9 0.0354282
SET SET nuclear proto-oncogene 0.035197
IGF1R insulin-like growth factor 1 receptor 0.0350811
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.034493
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0343971
GSE1 Gse1 coiled-coil protein 0.0343875
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0343281
WDR43 WD repeat domain 43 0.034148
PHF21A PHD finger protein 21A 0.0340447
MARCHF6 membrane associated ring-CH-type finger 6 0.0338191
FBXO11 F-box protein 11 0.03374
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0337129
CPNE1 copine I 0.0336507
EIF4A2 eukaryotic translation initiation factor 4A2 0.0336091
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0334923
NAP1L1 nucleosome assembly protein 1-like 1 0.0333783
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0332902
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0329597
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0329414
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0326127
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0325346
GLS2 glutaminase 2 (liver, mitochondrial) 0.0322464

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.117381
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112951
VIM vimentin -0.0681651
TOP2A topoisomerase (DNA) II alpha 170kDa -0.068064
PCDH9 protocadherin 9 -0.0504671
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0447298
CADM2 cell adhesion molecule 2 -0.044085
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0427961
HMGA1 high mobility group AT-hook 1 -0.04193
ENO1 enolase 1, (alpha) -0.0381877
GPC3 glypican 3 -0.0352616
TMSB10 thymosin beta 10 -0.035019
RPLP1 ribosomal protein, large, P1 -0.0323785
MDK midkine (neurite growth-promoting factor 2) -0.0322668
MAP4 microtubule-associated protein 4 -0.03208
FTL ferritin, light polypeptide -0.0316518
ADGRG6 adhesion G protein-coupled receptor G6 -0.0307266
SLC44A5 solute carrier family 44, member 5 -0.0277198
HMGB1 high mobility group box 1 -0.0276005
RPS27A ribosomal protein S27a -0.0275503
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0266271
RPL19 ribosomal protein L19 -0.0252377
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0252013
RAD51B RAD51 paralog B -0.0249415
LYST lysosomal trafficking regulator -0.0236492
MT2A metallothionein 2A -0.023615
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0230178
ZBTB20 zinc finger and BTB domain containing 20 -0.0223057
TRIQK triple QxxK/R motif containing -0.0222726
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0220099
ARHGAP15 Rho GTPase activating protein 15 -0.0216683
RPS6 ribosomal protein S6 -0.0215905
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209804
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0209704
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0209384
LMAN1 lectin, mannose-binding, 1 -0.0207773
RPL35A ribosomal protein L35a -0.0202502
RPS25 ribosomal protein S25 -0.0201422
RHOBTB3 Rho-related BTB domain containing 3 -0.0199538
RPL23 ribosomal protein L23 -0.019603
BICD1 bicaudal D homolog 1 (Drosophila) -0.0195775
POTEF POTE ankyrin domain family, member F -0.0195197
SGO2 shugoshin 2 -0.0193381
SMC4 structural maintenance of chromosomes 4 -0.0192797
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -0.0192756
S100A10 S100 calcium binding protein A10 -0.0191787
RPS11 ribosomal protein S11 -0.0190514
TPT1 tumor protein, translationally-controlled 1 -0.018898
RPL37A ribosomal protein L37a -0.0186041
NIPSNAP2 nipsnap homolog 2 -0.0185673
BCAS3 breast carcinoma amplified sequence 3 -0.018558
WDR45B WD repeat domain 45B -0.0185486
NRXN1 neurexin 1 -0.0184415
DEK DEK proto-oncogene -0.0184181
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0183402
RPS12 ribosomal protein S12 -0.018274
RPLP0 ribosomal protein, large, P0 -0.0181934
DOK6 docking protein 6 -0.0181851
NEBL nebulette -0.0178824
RPL31 ribosomal protein L31 -0.0177432
PFN1 profilin 1 -0.0171951
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0171197
RPL26 ribosomal protein L26 -0.0170562
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0170524
ZMYM1 zinc finger, MYM-type 1 -0.0170098
PROS1 protein S (alpha) -0.0168567
B2M beta-2-microglobulin -0.0167424
ZFPM2 zinc finger protein, FOG family member 2 -0.0165327
TAPBP TAP binding protein (tapasin) -0.0165079
THBS1 thrombospondin 1 -0.0164738
RPL9 ribosomal protein L9 -0.0164464
CD46 CD46 molecule, complement regulatory protein -0.0163803
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0163695
RPS23 ribosomal protein S23 -0.0162581
CCDC102B coiled-coil domain containing 102B -0.0162422
RPS15 ribosomal protein S15 -0.0161097
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0160829
TEX11 testis expressed 11 -0.0159843
NPAS3 neuronal PAS domain protein 3 -0.0159825
RHOA ras homolog family member A -0.0159718
ISG15 ISG15 ubiquitin-like modifier -0.015855
SPTSSA serine palmitoyltransferase, small subunit A -0.0156749
CYB5R3 cytochrome b5 reductase 3 -0.0155489
ARHGAP24 Rho GTPase activating protein 24 -0.0155448
LRMDA leucine rich melanocyte differentiation associated -0.0154717
RPS29 ribosomal protein S29 -0.0153936
ELOVL6 ELOVL fatty acid elongase 6 -0.0153921
TMCC1 transmembrane and coiled-coil domain family 1 -0.01537
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0153399
IER3 immediate early response 3 -0.0152622
RPL34 ribosomal protein L34 -0.0152451
PFN2 profilin 2 -0.0152279
SUMF2 sulfatase modifying factor 2 -0.0151457
RPS2 ribosomal protein S2 -0.0151171
RPS8 ribosomal protein S8 -0.0150617
RPS19 ribosomal protein S19 -0.0149506
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0148896
CFL2 cofilin 2 (muscle) -0.0147293
CNRIP1 cannabinoid receptor interacting protein 1 -0.0146831
RPL36 ribosomal protein L36 -0.0145762