DTP3_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description DTP3 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the DTP3_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0995921
MYH9 myosin, heavy chain 9, non-muscle 0.0949249
CEP250 centrosomal protein 250kDa 0.0778028
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0766855
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.073274
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0634129
ZSWIM6 zinc finger, SWIM-type containing 6 0.0628175
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0604985
SMAD3 SMAD family member 3 0.0604491
DSCAM Down syndrome cell adhesion molecule 0.0603896
DST dystonin 0.0602137
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0601798
NONO non-POU domain containing, octamer-binding 0.0594096
CPNE1 copine I 0.0591331
SMYD3 SET and MYND domain containing 3 0.0571949
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0549102
TRIO trio Rho guanine nucleotide exchange factor 0.05342
BIRC3 baculoviral IAP repeat containing 3 0.0533524
EEF2 eukaryotic translation elongation factor 2 0.0532936
TNIP1 TNFAIP3 interacting protein 1 0.0496309
SET SET nuclear proto-oncogene 0.049321
ANKRD11 ankyrin repeat domain 11 0.0489146
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047015
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0464127
INTS6 integrator complex subunit 6 0.0459649
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0458247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0436798
POTEF POTE ankyrin domain family, member F 0.0432027
PKM pyruvate kinase, muscle 0.0418802
MSN moesin 0.0413675
MPRIP myosin phosphatase Rho interacting protein 0.0413671
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0412127
HSPA8 heat shock 70kDa protein 8 0.0409093
FLNA filamin A, alpha 0.040707
NUMA1 nuclear mitotic apparatus protein 1 0.04069
STEAP3 STEAP family member 3, metalloreductase 0.0404961
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.039334
MED13L mediator complex subunit 13-like 0.0389268
FMNL2 formin-like 2 0.0384196
SRRM2 serine/arginine repetitive matrix 2 0.0380928
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0374554
ACTN1 actinin, alpha 1 0.037335
YBX3 Y box binding protein 3 0.036581
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0365383
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0364528
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0361083
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0358428
NIBAN2 niban apoptosis regulator 2 0.03582
OGA O-GlcNAcase 0.0357184
MACF1 microtubule-actin crosslinking factor 1 0.0356725
RANBP2 RAN binding protein 2 0.0354193
CSNK1A1 casein kinase 1, alpha 1 0.035201
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0349233
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0347951
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0343219
SHB Src homology 2 domain containing adaptor protein B 0.034301
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0340335
CD59 CD59 molecule, complement regulatory protein 0.0337806
RPL3 ribosomal protein L3 0.03346
FUS FUS RNA binding protein 0.0333194
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0332302
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0329348
NFE2L2 nuclear factor, erythroid 2-like 2 0.0323271
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0320452
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0319871
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0315687
UBE2H ubiquitin-conjugating enzyme E2H 0.0314265
NDRG1 N-myc downstream regulated 1 0.0311383
SEPTIN9 septin 9 0.0308968
PRKCA protein kinase C, alpha 0.0307466
BICD1 bicaudal D homolog 1 (Drosophila) 0.0306948
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0305024
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0301277
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02992
PICALM phosphatidylinositol binding clathrin assembly protein 0.0297948
KDM4B lysine (K)-specific demethylase 4B 0.0296635
CXCL8 chemokine (C-X-C motif) ligand 8 0.0294493
ANKRD36 ankyrin repeat domain 36 0.0294103
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0294017
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0293094
LMO7 LIM domain 7 0.0290336
AFF4 AF4/FMR2 family, member 4 0.0287811
ZNF638 zinc finger protein 638 0.0285679
SEPTIN2 septin 2 0.0284488
TBC1D5 TBC1 domain family, member 5 0.0282817
VMP1 vacuole membrane protein 1 0.0282229
GIGYF2 GRB10 interacting GYF protein 2 0.0282222
PRRC2C proline-rich coiled-coil 2C 0.0281491
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0281235
WNK1 WNK lysine deficient protein kinase 1 0.027828
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0277486
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0275121
EXT1 exostosin glycosyltransferase 1 0.0274017
FAM168A family with sequence similarity 168, member A 0.027331
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0271563
CALR calreticulin 0.0268375
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0264821
DARS1 aspartyl-tRNA synthetase 1 0.0262214
BHLHE40 basic helix-loop-helix family, member e40 0.0262115
SIK3 SIK family kinase 3 0.0258444

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.397272
VIM vimentin -0.0829545
TMSB10 thymosin beta 10 -0.077911
TPT1 tumor protein, translationally-controlled 1 -0.0641503
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0549536
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0484237
TM4SF1 transmembrane 4 L six family member 1 -0.0471882
PNRC1 proline-rich nuclear receptor coactivator 1 -0.047066
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0419389
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0378099
FTH1 ferritin, heavy polypeptide 1 -0.0359457
MBD5 methyl-CpG binding domain protein 5 -0.0354459
BTG1 B-cell translocation gene 1, anti-proliferative -0.0348194
NT5E 5'-nucleotidase, ecto (CD73) -0.0348049
TAS2R14 taste receptor, type 2, member 14 -0.0330178
NALCN sodium leak channel, non selective -0.0316465
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0306292
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0303954
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0302994
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0298968
GPC6 glypican 6 -0.0296891
TPM4 tropomyosin 4 -0.0294054
COPB1 coatomer protein complex, subunit beta 1 -0.0293103
BASP1 brain abundant, membrane attached signal protein 1 -0.028966
SEPTIN7 septin 7 -0.0287692
GCC2 GRIP and coiled-coil domain containing 2 -0.0286886
MAP1B microtubule-associated protein 1B -0.0284149
RAB1A RAB1A, member RAS oncogene family -0.0280305
RPL34 ribosomal protein L34 -0.0277698
S100A10 S100 calcium binding protein A10 -0.0277381
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.027579
DERA deoxyribose-phosphate aldolase (putative) -0.0275603
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.027106
GLCCI1 glucocorticoid induced 1 -0.0269578
IFIH1 interferon induced with helicase C domain 1 -0.0268931
FBXL2 F-box and leucine-rich repeat protein 2 -0.0267843
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0267811
RPLP1 ribosomal protein, large, P1 -0.0255618
LCORL ligand dependent nuclear receptor corepressor-like -0.0253676
NEMF nuclear export mediator factor -0.025213
PDCD6IP programmed cell death 6 interacting protein -0.0250392
TMEM123 transmembrane protein 123 -0.0248703
UBB ubiquitin B -0.0246787
PHACTR4 phosphatase and actin regulator 4 -0.0243456
RPL12 ribosomal protein L12 -0.0243154
GOSR1 golgi SNAP receptor complex member 1 -0.0242608
NIPBL Nipped-B homolog (Drosophila) -0.0241133
EFNA5 ephrin-A5 -0.0237218
ACTG1 actin gamma 1 -0.0231716
IGF2 insulin-like growth factor 2 -0.0231053
RIGI RNA sensor RIG-I -0.0230422
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0229218
RPL30 ribosomal protein L30 -0.0227739
TP53 tumor protein p53 -0.0227462
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0227074
ANKRD12 ankyrin repeat domain 12 -0.0226071
MARCHF7 membrane associated ring-CH-type finger 7 -0.0225963
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0223999
ZNF721 zinc finger protein 721 -0.0222484
ENOSF1 enolase superfamily member 1 -0.0222287
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0222256
SLC35F3 solute carrier family 35, member F3 -0.022006
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0217074
ZFR zinc finger RNA binding protein -0.0214991
CCNI cyclin I -0.0214516
MIS18BP1 MIS18 binding protein 1 -0.0213804
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0207903
CAV1 caveolin 1, caveolae protein, 22kDa -0.0205943
HMGB1 high mobility group box 1 -0.0203311
MTDH metadherin -0.020312
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0201816
LDLR low density lipoprotein receptor -0.0200204
RAI14 retinoic acid induced 14 -0.0199867
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.019961
PAPOLA poly(A) polymerase alpha -0.0197133
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0196781
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0196239
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0194993
IER3 immediate early response 3 -0.019333
ZBTB20 zinc finger and BTB domain containing 20 -0.019325
ANKRD28 ankyrin repeat domain 28 -0.0192431
OSMR oncostatin M receptor -0.0191651
PRH1 proline-rich protein HaeIII subfamily 1 -0.0191
LMAN1 lectin, mannose-binding, 1 -0.0190075
FCHO2 FCH domain only 2 -0.0188264
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0188222
TMEM263 transmembrane protein 263 -0.0187365
HMGA2 high mobility group AT-hook 2 -0.0187182
WSB1 WD repeat and SOCS box containing 1 -0.018619
ERBIN erbb2 interacting protein -0.0185389
BIRC2 baculoviral IAP repeat containing 2 -0.0185311
RFX7 regulatory factor X, 7 -0.0181718
FSCN1 fascin actin-bundling protein 1 -0.0181603
LDHA lactate dehydrogenase A -0.0181457
FKBP10 FK506 binding protein 10, 65 kDa -0.0180836
FAF2 Fas associated factor family member 2 -0.0179457
LARP1 La ribonucleoprotein domain family, member 1 -0.017912
TPST1 tyrosylprotein sulfotransferase 1 -0.0177517
ANKRD37 ankyrin repeat domain 37 -0.01769
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0174602