DU-145 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description A immortal human prostate gland-derived cell line cell that has the characteristics: Human cell line derived from brain metastasis of prostate carcinoma. TKG0604(Deposited from Tohoku Univ.). (Cell Line Ontology, CLO_0051536)
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Genes

331 genes with high or low expression in DU-145 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
STRN3 striatin, calmodulin binding protein 3 3.5826
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 3.25336
CEP55 centrosomal protein 55kDa 3.01901
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.00669
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 2.90792
KIAA0391 KIAA0391 2.69469
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.60336
MPDU1 mannose-P-dolichol utilization defect 1 2.54058
USP25 ubiquitin specific peptidase 25 2.49161
SCFD1 sec1 family domain containing 1 2.45452
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 2.43611
TMX1 thioredoxin-related transmembrane protein 1 2.41019
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.37295
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 2.337
TUBGCP5 tubulin, gamma complex associated protein 5 2.33515
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.31945
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.31839
ERBB2IP erbb2 interacting protein 2.15354
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.1414
MYO19 myosin XIX 2.11827
LRRC20 leucine rich repeat containing 20 2.01871
KIAA0100 KIAA0100 1.99684
KCTD9 potassium channel tetramerization domain containing 9 1.97142
ARHGAP5 Rho GTPase activating protein 5 1.96708
CUTC cutC copper transporter 1.95258
TMOD3 tropomodulin 3 (ubiquitous) 1.93819
DONSON downstream neighbor of SON 1.92633
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.90648
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 1.90135
EFHD2 EF-hand domain family, member D2 1.89204
PITRM1 pitrilysin metallopeptidase 1 1.88757
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) 1.86972
GUF1 GUF1 GTPase homolog (S. cerevisiae) 1.85455
NUMB numb homolog (Drosophila) 1.83421
TIAM2 T-cell lymphoma invasion and metastasis 2 1.83268
RNF115 ring finger protein 115 1.80806
VCP valosin containing protein 1.80523
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 1.80455
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 1.79654
SPAG5 sperm associated antigen 5 1.78838
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.76967
RANBP1 RAN binding protein 1 1.76467
OSMR oncostatin M receptor 1.75933
SRP54 signal recognition particle 54kDa 1.74952
KIF23 kinesin family member 23 1.74632
LOC400655 uncharacterized LOC400655 1.72919
MBIP MAP3K12 binding inhibitory protein 1 1.7234
TKTL1 transketolase-like 1 1.71374
COMMD3 COMM domain containing 3 1.69006
AVPI1 arginine vasopressin-induced 1 1.68554
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.68166
RNASEH1 ribonuclease H1 1.67019
SS18 synovial sarcoma translocation, chromosome 18 1.65854
KLHDC2 kelch domain containing 2 1.6516
TXNRD2 thioredoxin reductase 2 1.64964
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 1.64812
H2BFS H2B histone family, member S (pseudogene) 1.63635
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 1.63367
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.62197
EIF5A eukaryotic translation initiation factor 5A 1.62049
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 1.61766
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.60512
ADK adenosine kinase 1.59192
FLII flightless I homolog (Drosophila) 1.59157
DBR1 debranching RNA lariats 1 1.58977
CEP76 centrosomal protein 76kDa 1.58687
BAG2 BCL2-associated athanogene 2 1.58376
HEATR3 HEAT repeat containing 3 1.58293
ATP10A ATPase, class V, type 10A 1.57446
NUP155 nucleoporin 155kDa 1.56618
BAZ1A bromodomain adjacent to zinc finger domain, 1A 1.55669
ELAC2 elaC ribonuclease Z 2 1.55476
TIPIN TIMELESS interacting protein 1.54865
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.54616
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 1.54252
CDC6 cell division cycle 6 1.5303
UGDH UDP-glucose 6-dehydrogenase 1.52202
COMMD4 COMM domain containing 4 1.52183
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 1.5176
MAP3K14 mitogen-activated protein kinase kinase kinase 14 1.51353
UBXN8 UBX domain protein 8 1.51076
ADGRG6 adhesion G protein-coupled receptor G6 1.49999
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 1.49713
ANXA7 annexin A7 1.49343
KIAA0586 KIAA0586 1.48226
MRPL19 mitochondrial ribosomal protein L19 1.46735
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.46721
WISP2 WNT1 inducible signaling pathway protein 2 1.46462
CORO1C coronin, actin binding protein, 1C 1.46393
CBR1 carbonyl reductase 1 1.46153
PRPF4 pre-mRNA processing factor 4 1.45282
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.45057
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 1.44983
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.44913
MELK maternal embryonic leucine zipper kinase 1.44822
ZFYVE21 zinc finger, FYVE domain containing 21 1.44039
ARF6 ADP-ribosylation factor 6 1.43297
STOML2 stomatin (EPB72)-like 2 1.4291
ARMC7 armadillo repeat containing 7 1.42395
SMC2 structural maintenance of chromosomes 2 1.42074

low expression

Symbol Name Standardized Value
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -3.53725
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -3.52922
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -3.045
MACROD1 MACRO domain containing 1 -3.04096
KEAP1 kelch-like ECH-associated protein 1 -2.98313
GLTSCR2 glioma tumor suppressor candidate region gene 2 -2.95461
PHF3 PHD finger protein 3 -2.81212
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.7939
SNTG1 syntrophin, gamma 1 -2.76971
PEX16 peroxisomal biogenesis factor 16 -2.76169
PRB4 proline-rich protein BstNI subfamily 4 -2.75973
DGKB diacylglycerol kinase, beta 90kDa -2.73719
CBX4 chromobox homolog 4 -2.71233
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 -2.69099
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -2.67881
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.66517
KIAA1217 KIAA1217 -2.63538
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -2.62678
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.61654
ALK anaplastic lymphoma receptor tyrosine kinase -2.60133
CADM3 cell adhesion molecule 3 -2.51642
SYT5 synaptotagmin V -2.51187
CORT cortistatin -2.51154
RPS4X ribosomal protein S4, X-linked -2.47768
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.43038
CCDC14 coiled-coil domain containing 14 -2.37819
UBN1 ubinuclein 1 -2.355
DOPEY1 dopey family member 1 -2.31182
ESR1 estrogen receptor 1 -2.30106
MPC1 mitochondrial pyruvate carrier 1 -2.2811
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -2.26643
SOX5 SRY (sex determining region Y)-box 5 -2.24014
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.23857
SARM1 sterile alpha and TIR motif containing 1 -2.23564
GRIK1 glutamate receptor, ionotropic, kainate 1 -2.22293
NPR1 natriuretic peptide receptor 1 -2.21916
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.21465
TTLL1 tubulin tyrosine ligase-like family member 1 -2.21464
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -2.19388
TSPAN31 tetraspanin 31 -2.1902
TBL3 transducin (beta)-like 3 -2.18438
EMD emerin -2.17604
IL12RB2 interleukin 12 receptor, beta 2 -2.17256
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -2.16851
CEP104 centrosomal protein 104kDa -2.1672
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.16107
RRAGC Ras-related GTP binding C -2.14208
PADI4 peptidyl arginine deiminase, type IV -2.14138
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2) -2.13937
CD52 CD52 molecule -2.13093
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.12608
BBC3 BCL2 binding component 3 -2.12053
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.11598
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.10767
SULF1 sulfatase 1 -2.09439
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.09415
ECM1 extracellular matrix protein 1 -2.08992
LAMB4 laminin, beta 4 -2.08189
PRSS1 protease, serine, 1 (trypsin 1) -2.08116
DMRT1 doublesex and mab-3 related transcription factor 1 -2.07763
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.04551
LRRC17 leucine rich repeat containing 17 -2.03491
PER2 period circadian clock 2 -2.0306
TMEM184C transmembrane protein 184C -2.02372
TRAPPC6A trafficking protein particle complex 6A -2.02172
GNRHR gonadotropin-releasing hormone receptor -2.00588
CDH8 cadherin 8, type 2 -2.0009
IL2 interleukin 2 -1.98809
FAM3A family with sequence similarity 3, member A -1.97381
FABP3 fatty acid binding protein 3, muscle and heart -1.95762
RPS11 ribosomal protein S11 -1.93181
SLC16A4 solute carrier family 16, member 4 -1.92848
LIMS2 LIM and senescent cell antigen-like domains 2 -1.90768
DRG2 developmentally regulated GTP binding protein 2 -1.90065
TPT1 tumor protein, translationally-controlled 1 -1.87031
ACE2 angiotensin I converting enzyme 2 -1.8688
SSR4 signal sequence receptor, delta -1.86741
RPL39 ribosomal protein L39 -1.86694
CELF1 CUGBP, Elav-like family member 1 -1.86637
MLANA melan-A -1.85346
RXRB retinoid X receptor, beta -1.84548
GZMK granzyme K (granzyme 3; tryptase II) -1.83816
WDTC1 WD and tetratricopeptide repeats 1 -1.83583
NADSYN1 NAD synthetase 1 -1.83217
IGF1 insulin-like growth factor 1 (somatomedin C) -1.82844
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -1.82801
TAL1 T-cell acute lymphocytic leukemia 1 -1.82782
PSG9 pregnancy specific beta-1-glycoprotein 9 -1.82223
KIAA0556 KIAA0556 -1.81276
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -1.80742
RPS15A ribosomal protein S15a -1.78982
RPL5 ribosomal protein L5 -1.78739
MYBPC1 myosin binding protein C, slow type -1.78605
ZNF440 zinc finger protein 440 -1.77631
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -1.7752
ZNF174 zinc finger protein 174 -1.77512
USP36 ubiquitin specific peptidase 36 -1.77073
ADRA1D adrenoceptor alpha 1D -1.7704
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -1.7691
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -1.76908
AKAP4 A kinase (PRKA) anchor protein 4 -1.74312
RPL28 ribosomal protein L28 -1.72636
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 -1.72546
SUCLG1 succinate-CoA ligase, alpha subunit -1.72505
SLIT3 slit homolog 3 (Drosophila) -1.72502
IFNA8 interferon, alpha 8 -1.72468
COL1A2 collagen, type I, alpha 2 -1.72315
TAS2R4 taste receptor, type 2, member 4 -1.72239
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 -1.71956
TAS2R1 taste receptor, type 2, member 1 -1.71459
ING4 inhibitor of growth family, member 4 -1.7135
PEG3 paternally expressed 3 -1.70866
COL7A1 collagen, type VII, alpha 1 -1.70765
CAPN3 calpain 3, (p94) -1.70649
AMPD2 adenosine monophosphate deaminase 2 -1.70107
PTPRA protein tyrosine phosphatase, receptor type, A -1.69984
DAPK2 death-associated protein kinase 2 -1.69137
KAT8 K(lysine) acetyltransferase 8 -1.68731
CLEC4A C-type lectin domain family 4, member A -1.68246
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene) -1.68024
PIDD1 p53-induced death domain protein 1 -1.67553
GPC6 glypican 6 -1.67417
ONECUT2 one cut homeobox 2 -1.66401
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -1.66159
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -1.66097
RPS8 ribosomal protein S8 -1.6563
CLCA3P chloride channel accessory 3, pseudogene -1.65432
WWOX WW domain containing oxidoreductase -1.65345
PTOV1 prostate tumor overexpressed 1 -1.65255
TBX2 T-box 2 -1.6513
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -1.64928
KLHL24 kelch-like family member 24 -1.64687
RPL10 ribosomal protein L10 -1.63931
SIKE1 suppressor of IKBKE 1 -1.63639
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -1.63368
HLA-DOA major histocompatibility complex, class II, DO alpha -1.63235
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -1.63033
SCN10A sodium channel, voltage gated, type X alpha subunit -1.62885
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 -1.6269
PPIB peptidylprolyl isomerase B (cyclophilin B) -1.62655
SRRM2 serine/arginine repetitive matrix 2 -1.62189
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -1.62054
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -1.61911
DYNLRB1 dynein, light chain, roadblock-type 1 -1.61227
SLC41A3 solute carrier family 41, member 3 -1.60641
GK2 glycerol kinase 2 -1.59611
FRG1 FSHD region gene 1 -1.59482
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -1.59469
ZNF136 zinc finger protein 136 -1.59364
MUSK muscle, skeletal, receptor tyrosine kinase -1.59286
AQP4 aquaporin 4 -1.59251
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -1.58809
GLRA1 glycine receptor, alpha 1 -1.58532
TTC19 tetratricopeptide repeat domain 19 -1.5809
KIAA0195 KIAA0195 -1.57628
RPL18 ribosomal protein L18 -1.57071
MNT MAX network transcriptional repressor -1.56984
OCA2 oculocutaneous albinism II -1.56933
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -1.56595
SIRT3 sirtuin 3 -1.56245
LOC390998 ribosomal protein L10 pseudogene -1.55986
ASPN asporin -1.55889
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -1.55868
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -1.55206
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -1.55141
AHSP alpha hemoglobin stabilizing protein -1.55023
ELL elongation factor RNA polymerase II -1.54883
CHN2 chimerin 2 -1.54773
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -1.53969
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -1.53963
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) -1.53934
MYO15B myosin XVB -1.53783
SCRG1 stimulator of chondrogenesis 1 -1.53419
GATA4 GATA binding protein 4 -1.53388
CCNG2 cyclin G2 -1.53136
LCMT1 leucine carboxyl methyltransferase 1 -1.52592
PGLS 6-phosphogluconolactonase -1.51963
SPATA1 spermatogenesis associated 1 -1.51902
RPS18 ribosomal protein S18 -1.51832
SPANXC SPANX family, member C -1.51792
MAB21L1 mab-21-like 1 (C. elegans) -1.51669
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -1.51638
GLI3 GLI family zinc finger 3 -1.51597
SMR3A submaxillary gland androgen regulated protein 3A -1.50687
ZNF197 zinc finger protein 197 -1.50668
MRPL23 mitochondrial ribosomal protein L23 -1.50428
KDM8 lysine (K)-specific demethylase 8 -1.5041
SSBP3 single stranded DNA binding protein 3 -1.50154
EIF3F eukaryotic translation initiation factor 3, subunit F -1.50036
SSX2 synovial sarcoma, X breakpoint 2 -1.50022
MOSPD2 motile sperm domain containing 2 -1.4991
DNAH9 dynein, axonemal, heavy chain 9 -1.49557
FAM13C family with sequence similarity 13, member C -1.49503
FGF5 fibroblast growth factor 5 -1.49157
PEMT phosphatidylethanolamine N-methyltransferase -1.4891
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -1.48327
RPL41 ribosomal protein L41 -1.48232
USP27X ubiquitin specific peptidase 27, X-linked -1.47975
KLC2 kinesin light chain 2 -1.47481
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -1.47364
UBOX5 U-box domain containing 5 -1.46864
CD3G CD3g molecule, gamma (CD3-TCR complex) -1.46545
CARTPT CART prepropeptide -1.46489
MATN1 matrilin 1, cartilage matrix protein -1.46443
CFAP44 cilia and flagella associated protein 44 -1.46401
DPYS dihydropyrimidinase -1.46382
EMX2 empty spiracles homeobox 2 -1.4627
ZNF407 zinc finger protein 407 -1.45783
DNPEP aspartyl aminopeptidase -1.45549
KCTD13 potassium channel tetramerization domain containing 13 -1.45488
MEFV Mediterranean fever -1.45272
HGFAC HGF activator -1.4505
F7 coagulation factor VII (serum prothrombin conversion accelerator) -1.4482
ANGPTL2 angiopoietin-like 2 -1.4464
FAM53B family with sequence similarity 53, member B -1.44505
FPR1 formyl peptide receptor 1 -1.4441
LY96 lymphocyte antigen 96 -1.44323
PUM1 pumilio RNA-binding family member 1 -1.44283
ATF6 activating transcription factor 6 -1.4415
EIF5A2 eukaryotic translation initiation factor 5A2 -1.44145
PHF8 PHD finger protein 8 -1.43711
ZNF142 zinc finger protein 142 -1.43572
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -1.43165
PLEKHA5 pleckstrin homology domain containing, family A member 5 -1.43035
ISL1 ISL LIM homeobox 1 -1.42856
TRDN triadin -1.42796
IL23A interleukin 23, alpha subunit p19 -1.42492
IL17A interleukin 17A -1.42489
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -1.42446
EFNA2 ephrin-A2 -1.42027
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -1.41752