| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5497124 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in DY 131 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 1.3 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 1.08 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.07 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.94 |
| NCOA4 | nuclear receptor coactivator 4 | 0.9 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.87 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.81 |
| PDGFC | platelet derived growth factor C | 0.6 |
| CCND1 | cyclin D1 | 0.56 |
| FAS | Fas cell surface death receptor | 0.56 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.55 |
| ADIPOR1 | adiponectin receptor 1 | 0.53 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.53 |
| GRAMD2A | GRAM domain containing 2A | 0.52 |
| PDE8A | phosphodiesterase 8A | 0.52 |
| ZNF711 | zinc finger protein 711 | 0.51 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.5 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | 0.47 |
| SLC25A46 | solute carrier family 25, member 46 | 0.47 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.46 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.46 |
| TP53 | tumor protein p53 | 0.45 |
| KLHL25 | kelch-like family member 25 | 0.45 |
| SMOX | spermine oxidase | 0.44 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.44 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | 0.42 |
| CDX2 | caudal type homeobox 2 | 0.42 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.42 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.42 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.42 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.41 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 0.41 |
| SLC25A52 | solute carrier family 25, member 52 | 0.4 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.4 |
| DTNB | dystrobrevin, beta | 0.4 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.39 |
| CLDN3 | claudin 3 | 0.39 |
| IREB2 | iron-responsive element binding protein 2 | 0.38 |
| COBL | cordon-bleu WH2 repeat protein | 0.38 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.38 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.37 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.37 |
| ZNF729 | zinc finger protein 729 | 0.37 |
| RHOA | ras homolog family member A | 0.37 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | 0.37 |
| PRXL2A | peroxiredoxin like 2A | 0.37 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.37 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.36 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.36 |
| PLK2 | polo-like kinase 2 | 0.36 |
| SESN1 | sestrin 1 | 0.36 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.36 |
| CPA4 | carboxypeptidase A4 | 0.35 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.35 |
| NRBF2 | nuclear receptor binding factor 2 | 0.35 |
| TP73 | tumor protein p73 | 0.34 |
| SMTN | smoothelin | 0.34 |
| SMIM12 | small integral membrane protein 12 | 0.34 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.34 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.33 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 0.33 |
| POLH | polymerase (DNA directed), eta | 0.33 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.33 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.33 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.33 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.33 |
| DAP | death-associated protein | 0.33 |
| C12ORF45 | chromosome 12 open reading frame 45 | 0.33 |
| BDNF | brain-derived neurotrophic factor | 0.33 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | 0.33 |
| SUSD2 | sushi domain containing 2 | 0.33 |
| SLC38A2 | solute carrier family 38, member 2 | 0.32 |
| MLH3 | mutL homolog 3 | 0.32 |
| GDF15 | growth differentiation factor 15 | 0.32 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.32 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.32 |
| DNAJC14 | DnaJ (Hsp40) homolog, subfamily C, member 14 | 0.32 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 0.32 |
| FXN | frataxin | 0.32 |
| MAPRE3 | microtubule-associated protein, RP/EB family, member 3 | 0.31 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.31 |
| SLC22A18 | solute carrier family 22, member 18 | 0.31 |
| FAT3 | FAT atypical cadherin 3 | 0.3 |
| JUN | jun proto-oncogene | 0.3 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.3 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.3 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.29 |
| SPEG | SPEG complex locus | 0.29 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.29 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.29 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.29 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | 0.29 |
| GOLGA4 | golgin A4 | 0.29 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 0.29 |
| PPFIA3 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 | 0.29 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.29 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.28 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 0.28 |
| BORCS6 | BLOC-1 related complex subunit 6 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STK17A | serine/threonine kinase 17a | -1.17 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -1.13 |
| TMEM67 | transmembrane protein 67 | -1.1 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | -0.96 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.92 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.87 |
| ZNF22 | zinc finger protein 22 | -0.81 |
| TSPAN15 | tetraspanin 15 | -0.73 |
| TRIM8 | tripartite motif containing 8 | -0.73 |
| FAM241B | family with sequence similarity 241 member B | -0.73 |
| KLF13 | Kruppel-like factor 13 | -0.72 |
| BSDC1 | BSD domain containing 1 | -0.71 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.69 |
| TMEM101 | transmembrane protein 101 | -0.66 |
| SGMS2 | sphingomyelin synthase 2 | -0.61 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.61 |
| IER5L | immediate early response 5-like | -0.59 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.59 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.59 |
| RWDD1 | RWD domain containing 1 | -0.58 |
| TAF1A | TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa | -0.58 |
| RHOF | ras homolog family member F (in filopodia) | -0.57 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | -0.56 |
| ZNF286B | zinc finger protein 286B | -0.56 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.55 |
| KLHL15 | kelch-like family member 15 | -0.54 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | -0.54 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.54 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.54 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.54 |
| TAZ | tafazzin | -0.53 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -0.52 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.51 |
| CDC25A | cell division cycle 25A | -0.51 |
| TRIM5 | tripartite motif containing 5 | -0.5 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.5 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -0.5 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | -0.49 |
| MRC2 | mannose receptor, C type 2 | -0.49 |
| MSMO1 | methylsterol monooxygenase 1 | -0.48 |
| ENO1 | enolase 1, (alpha) | -0.48 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.47 |
| FBXW5 | F-box and WD repeat domain containing 5 | -0.47 |
| LTO1 | LTO1 maturation factor of ABCE1 | -0.46 |
| ABAT | 4-aminobutyrate aminotransferase | -0.45 |
| TMLHE | trimethyllysine hydroxylase, epsilon | -0.45 |
| EMB | embigin | -0.45 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.45 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.45 |
| MON1B | MON1 secretory trafficking family member B | -0.44 |
| CCNE2 | cyclin E2 | -0.43 |
| LAMA5 | laminin, alpha 5 | -0.42 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.42 |
| FYTTD1 | forty-two-three domain containing 1 | -0.42 |
| GAB1 | GRB2-associated binding protein 1 | -0.42 |
| BRD3 | bromodomain containing 3 | -0.42 |
| CCDC150 | coiled-coil domain containing 150 | -0.42 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.41 |
| RBM41 | RNA binding motif protein 41 | -0.41 |
| ESRRA | estrogen-related receptor alpha | -0.41 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.4 |
| NIBAN1 | niban apoptosis regulator 1 | -0.4 |
| BBS1 | Bardet-Biedl syndrome 1 | -0.4 |
| RGN | regucalcin | -0.39 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.39 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | -0.39 |
| KCTD14 | potassium channel tetramerization domain containing 14 | -0.39 |
| ZNF761 | zinc finger protein 761 | -0.39 |
| FMNL1 | formin-like 1 | -0.38 |
| RAP1GAP | RAP1 GTPase activating protein | -0.38 |
| PRODH | proline dehydrogenase (oxidase) 1 | -0.38 |
| TMEM104 | transmembrane protein 104 | -0.38 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.38 |
| XYLT2 | xylosyltransferase II | -0.38 |
| MUTYH | mutY homolog | -0.38 |
| PLAUR | plasminogen activator, urokinase receptor | -0.38 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.38 |
| ACTBL2 | actin, beta-like 2 | -0.37 |
| SFXN5 | sideroflexin 5 | -0.37 |
| AMPD1 | adenosine monophosphate deaminase 1 | -0.37 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.36 |
| RAB20 | RAB20, member RAS oncogene family | -0.36 |
| MEAF6 | MYST/Esa1-associated factor 6 | -0.36 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -0.36 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -0.35 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.35 |
| METTL9 | methyltransferase like 9 | -0.35 |
| EXO1 | exonuclease 1 | -0.35 |
| RBM47 | RNA binding motif protein 47 | -0.35 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.35 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.35 |
| SORT1 | sortilin 1 | -0.35 |
| HHEX | hematopoietically expressed homeobox | -0.34 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.34 |
| SC5D | sterol-C5-desaturase | -0.34 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | -0.34 |
| RLF | rearranged L-myc fusion | -0.34 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.34 |
| MRFAP1 | Morf4 family associated protein 1 | -0.34 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -0.34 |
