DYRK1A Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A|This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1859)
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100 substrates of the kinase DYRK1A from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C19ORF26 chromosome 19 open reading frame 26
EPC1 enhancer of polycomb homolog 1 (Drosophila)
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R18 protein phosphatase 1, regulatory subunit 18
MICALL2 MICAL-like 2
TBX18 T-box 18
SYNPO2L synaptopodin 2-like
MAP7D1 MAP7 domain containing 1
IRAK3 interleukin-1 receptor-associated kinase 3
TTN titin
KMT2B lysine (K)-specific methyltransferase 2B
MED13 mediator complex subunit 13
SPEN spen family transcriptional repressor
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
MKI67 marker of proliferation Ki-67
GFPT1 glutamine--fructose-6-phosphate transaminase 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
DTX3L deltex 3 like, E3 ubiquitin ligase
ANKRD34A ankyrin repeat domain 34A
SIRT6 sirtuin 6
MED12 mediator complex subunit 12
KHNYN KH and NYN domain containing
SIK1 salt-inducible kinase 1
FLJ22184
CREBZF CREB/ATF bZIP transcription factor
PRRT3 proline-rich transmembrane protein 3
NHSL1 NHS-like 1
GLI2 GLI family zinc finger 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
SYT17 synaptotagmin XVII
LSM11 LSM11, U7 small nuclear RNA associated
ADRB1 adrenoceptor beta 1
GTF2I general transcription factor IIi
ZNF777 zinc finger protein 777
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
CENPA centromere protein A
SACK1H scaffolding CK1 anchoring protein H
USP20 ubiquitin specific peptidase 20
TPRN taperin
COL4A2 collagen, type IV, alpha 2
CADPS Ca++-dependent secretion activator
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBX21 T-box 21
ZZZ3 zinc finger, ZZ-type containing 3
INO80C INO80 complex subunit C
AMPH amphiphysin
HEYL hes-related family bHLH transcription factor with YRPW motif-like
RLF rearranged L-myc fusion
LMOD2 leiomodin 2 (cardiac)
WDR4 WD repeat domain 4
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
GATAD2A GATA zinc finger domain containing 2A
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SCAF11 SR-related CTD-associated factor 11
SPTBN1 spectrin, beta, non-erythrocytic 1
ZNF142 zinc finger protein 142
KIAA1211 KIAA1211
PTDSS2 phosphatidylserine synthase 2
MAP1A microtubule-associated protein 1A
MAP1S microtubule-associated protein 1S
SHANK1 SH3 and multiple ankyrin repeat domains 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
GAS2L1 growth arrest-specific 2 like 1
MTX1 metaxin 1
UBA6 ubiquitin-like modifier activating enzyme 6
UBAC1 UBA domain containing 1
XIRP2 xin actin binding repeat containing 2
RASL11A RAS-like, family 11, member A
MORC2 MORC family CW-type zinc finger 2
CASS4 Cas scaffolding protein family member 4
KIF1C kinesin family member 1C
C16ORF54 chromosome 16 open reading frame 54
METTL14 methyltransferase like 14
SHKBP1 SH3KBP1 binding protein 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAST2 microtubule associated serine/threonine kinase 2
MAST4 microtubule associated serine/threonine kinase family member 4
SSH2 slingshot protein phosphatase 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
SCAP SREBF chaperone
ASCL2 achaete-scute family bHLH transcription factor 2
KIF19 kinesin family member 19
SETD1A SET domain containing 1A
HSF1 heat shock transcription factor 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
FAM53C family with sequence similarity 53, member C
LOC102724428 serine/threonine-protein kinase SIK1
ITPKB inositol-trisphosphate 3-kinase B
ZNF318 zinc finger protein 318
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
MED12L mediator complex subunit 12-like
KIAA1804 mixed lineage kinase 4
BPTF bromodomain PHD finger transcription factor
RSPH3 radial spoke 3 homolog (Chlamydomonas)