DYRK1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A|This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1859)
External Link http://www.ncbi.nlm.nih.gov/gene/1859
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310 interacting proteins for DYRK1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACTB actin, beta
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2B activin A receptor, type IIB
ADAM28 ADAM metallopeptidase domain 28
ADCK1 aarF domain containing kinase 1
ADCK3 aarF domain containing kinase 3
ADK adenosine kinase
AFF4 AF4/FMR2 family, member 4
AHRR aryl-hydrocarbon receptor repressor
AKAP1 A kinase (PRKA) anchor protein 1
AKAP11 A kinase (PRKA) anchor protein 11
AKAP2 A kinase (PRKA) anchor protein 2
AKAP5 A kinase (PRKA) anchor protein 5
AKAP7 A kinase (PRKA) anchor protein 7
AKAP9 A kinase (PRKA) anchor protein 9
ALDOA aldolase A, fructose-bisphosphate
ALPK3 alpha-kinase 3
AMPH amphiphysin
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATAD3B ATPase family, AAA domain containing 3B
ATF2 activating transcription factor 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATXN2L ataxin 2-like
AURKA aurora kinase A
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
BARD1 BRCA1 associated RING domain 1
BMP2K BMP2 inducible kinase
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTK Bruton agammaglobulinemia tyrosine kinase
BUB3 BUB3 mitotic checkpoint protein
C1ORF116 chromosome 1 open reading frame 116
C2CD5 C2 calcium-dependent domain containing 5
C2ORF88 chromosome 2 open reading frame 88
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCDC8 coiled-coil domain containing 8
CCNA2 cyclin A2
CCND1 cyclin D1
CCNH cyclin H
CCNL2 cyclin L2
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CHD8 chromodomain helicase DNA binding protein 8
CLASRP CLK4-associating serine/arginine rich protein
CLK1 CDC-like kinase 1
CLTC clathrin, heavy chain (Hc)
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DCAF7 DDB1 and CUL4 associated factor 7
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNM1 dynamin 1
DOCK9 dedicator of cytokinesis 9
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3J eukaryotic translation initiation factor 3, subunit J
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
ERBB2IP erbb2 interacting protein
FAM117A family with sequence similarity 117, member A
FAM117B family with sequence similarity 117, member B
FAM53C family with sequence similarity 53, member C
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FNTA farnesyltransferase, CAAX box, alpha
FNTB farnesyltransferase, CAAX box, beta
FOXO1 forkhead box O1
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLCCI1 glucocorticoid induced 1
GLI1 GLI family zinc finger 1
GPR161 G protein-coupled receptor 161
GRAMD1A GRAM domain containing 1A
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BB histone cluster 1, H2bb
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KIAA0195 KIAA0195
KIAA0232 KIAA0232
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LATS2 large tumor suppressor kinase 2
LEMD3 LEM domain containing 3
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LIN37 lin-37 DREAM MuvB core complex component
LIN52 lin-52 DREAM MuvB core complex component
LIN54 lin-54 DREAM MuvB core complex component
LIN9 lin-9 DREAM MuvB core complex component
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS2 leucine zipper, putative tumor suppressor 2
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK9 mitogen-activated protein kinase 9
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPT microtubule-associated protein tau
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MELK maternal embryonic leucine zipper kinase
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCK2 NCK adaptor protein 2
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NLK nemo-like kinase
NQO2 NAD(P)H dehydrogenase, quinone 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NXPE4 neurexophilin and PC-esterase domain family, member 4
OPA1 optic atrophy 1 (autosomal dominant)
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKN3 protein kinase N3
PLK4 polo-like kinase 4
PPP1R3F protein phosphatase 1, regulatory subunit 3F
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSPC1 paraspeckle component 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RCAN1 regulator of calcineurin 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF169 ring finger protein 169
RPL3 ribosomal protein L3
RPL4 ribosomal protein L4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SACK1A scaffolding CK1 anchoring protein A
SACK1G scaffolding CK1 anchoring protein G
SEC16A SEC16 homolog A (S. cerevisiae)
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SH3GL2 SH3-domain GRB2-like 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIRT1 sirtuin 1
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLK STE20-like kinase
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNW1 SNW domain containing 1
SPEG SPEG complex locus
SPRY2 sprouty homolog 2 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF4 serine/arginine-rich splicing factor 4
SRSF5 serine/arginine-rich splicing factor 5
SSB Sjogren syndrome antigen B (autoantigen La)
STK16 serine/threonine kinase 16
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TCP1 t-complex 1
TEC tec protein tyrosine kinase
TESK2 testis-specific kinase 2
TGFBR1 transforming growth factor, beta receptor 1
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TP53 tumor protein p53
TRAF3 TNF receptor-associated factor 3
TRAP1 TNF receptor-associated protein 1
TROAP trophinin associated protein
TTN titin
TUBA1B tubulin, alpha 1b
TYK2 tyrosine kinase 2
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
ULK3 unc-51 like kinase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VAV2 vav 2 guanine nucleotide exchange factor
WEE1 WEE1 G2 checkpoint kinase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YY1 YY1 transcription factor
ZFYVE9 zinc finger, FYVE domain containing 9