| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism. (Chemical Entities of Biological Interest Ontology, CHEBI_70752) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/216210 |
| Similar Terms | |
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199 proteins with high or low expression in Dabigatran relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.58 |
| ABHD2 | abhydrolase domain containing 2 | 2.42 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.27 |
| APOB | apolipoprotein B | 2.26 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 2.08 |
| SQLE | squalene epoxidase | 1.82 |
| TSPAN3 | tetraspanin 3 | 1.72 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.65 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 1.61 |
| MSMO1 | methylsterol monooxygenase 1 | 1.58 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.52 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1.52 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.29 |
| DHCR7 | 7-dehydrocholesterol reductase | 1.28 |
| MVK | mevalonate kinase | 1.26 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.26 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 1.25 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 1.22 |
| TMEM59 | transmembrane protein 59 | 1.21 |
| UPP1 | uridine phosphorylase 1 | 1.2 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 1.16 |
| CD63 | CD63 molecule | 1.08 |
| ERG28 | ergosterol biosynthesis 28 homolog | 1.05 |
| SC5D | sterol-C5-desaturase | 1.04 |
| MVD | mevalonate (diphospho) decarboxylase | 0.99 |
| LDLR | low density lipoprotein receptor | 0.99 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.98 |
| RNF145 | ring finger protein 145 | 0.94 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.94 |
| NIBAN1 | niban apoptosis regulator 1 | 0.93 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.93 |
| SLC38A2 | solute carrier family 38, member 2 | 0.91 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.9 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.89 |
| FDPS | farnesyl diphosphate synthase | 0.85 |
| MCL1 | myeloid cell leukemia 1 | 0.83 |
| LPIN1 | lipin 1 | 0.78 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.77 |
| NCOA4 | nuclear receptor coactivator 4 | 0.75 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.73 |
| ITM2C | integral membrane protein 2C | 0.72 |
| HMOX1 | heme oxygenase 1 | 0.69 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.68 |
| ABHD3 | abhydrolase domain containing 3 | 0.67 |
| APOE | apolipoprotein E | 0.67 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.67 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.66 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.66 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.66 |
| C4BPA | complement component 4 binding protein, alpha | 0.64 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.62 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.62 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.62 |
| RTN4R | reticulon 4 receptor | 0.61 |
| NPC1 | Niemann-Pick disease, type C1 | 0.6 |
| FADS1 | fatty acid desaturase 1 | 0.6 |
| GALNS | galactosamine (N-acetyl)-6-sulfatase | 0.6 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.59 |
| NAV3 | neuron navigator 3 | 0.59 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.58 |
| SCARB1 | scavenger receptor class B, member 1 | 0.58 |
| ZNF92 | zinc finger protein 92 | 0.58 |
| RNF149 | ring finger protein 149 | 0.58 |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | 0.56 |
| TMEM41B | transmembrane protein 41B | 0.56 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.55 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.55 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.55 |
| AXIN1 | axin 1 | 0.54 |
| FASN | fatty acid synthase | 0.53 |
| CST6 | cystatin E/M | 0.52 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.52 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | 0.52 |
| TMEM97 | transmembrane protein 97 | 0.52 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.52 |
| PLPP2 | phospholipid phosphatase 2 | 0.51 |
| IGF1R | insulin-like growth factor 1 receptor | 0.51 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.51 |
| MPZL2 | myelin protein zero-like 2 | 0.5 |
| PRXL2A | peroxiredoxin like 2A | 0.5 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.49 |
| TTYH2 | tweety family member 2 | 0.49 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.48 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.48 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | 0.48 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.47 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.47 |
| PRSS8 | protease, serine, 8 | 0.47 |
| INHBA | inhibin, beta A | 0.47 |
| PLD3 | phospholipase D family, member 3 | 0.46 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.46 |
| GDF15 | growth differentiation factor 15 | 0.46 |
| ATP9A | ATPase, class II, type 9A | 0.46 |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 0.45 |
| ACLY | ATP citrate lyase | 0.45 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.45 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.45 |
| CTSA | cathepsin A | 0.44 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.44 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | -2.5 |
| ADIPOR1 | adiponectin receptor 1 | -1.02 |
| ANGPTL4 | angiopoietin-like 4 | -0.81 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.78 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.75 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.74 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.71 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.67 |
| ODC1 | ornithine decarboxylase 1 | -0.65 |
| NARF | nuclear prelamin A recognition factor | -0.64 |
| CRLF1 | cytokine receptor-like factor 1 | -0.62 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.62 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.62 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | -0.61 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.59 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.59 |
| PIMREG | PICALM interacting mitotic regulator | -0.58 |
| DSE | dermatan sulfate epimerase | -0.58 |
| FOXM1 | forkhead box M1 | -0.58 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | -0.53 |
| CPA4 | carboxypeptidase A4 | -0.53 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.52 |
| LIX1L | Lix1 homolog (chicken) like | -0.52 |
| NET1 | neuroepithelial cell transforming 1 | -0.5 |
| NAAA | N-acylethanolamine acid amidase | -0.49 |
| DONSON | downstream neighbor of SON | -0.49 |
| CCNB1 | cyclin B1 | -0.49 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.47 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.46 |
| TYMS | thymidylate synthetase | -0.46 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.44 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.44 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.44 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -0.44 |
| MARCKSL1 | MARCKS-like 1 | -0.43 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.43 |
| WDR90 | WD repeat domain 90 | -0.43 |
| TET2 | tet methylcytosine dioxygenase 2 | -0.43 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.43 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.42 |
| E2F7 | E2F transcription factor 7 | -0.42 |
| DUSP5 | dual specificity phosphatase 5 | -0.41 |
| GPR161 | G protein-coupled receptor 161 | -0.41 |
| MTERF1 | mitochondrial transcription termination factor 1 | -0.41 |
| GMIP | GEM interacting protein | -0.41 |
| CCNB2 | cyclin B2 | -0.41 |
| ZNF532 | zinc finger protein 532 | -0.41 |
| CRIP2 | cysteine-rich protein 2 | -0.4 |
| FOSL2 | FOS-like antigen 2 | -0.4 |
| KIF18B | kinesin family member 18B | -0.4 |
| CENPF | centromere protein F, 350/400kDa | -0.4 |
| COQ4 | coenzyme Q4 | -0.4 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.4 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.39 |
| ANLN | anillin, actin binding protein | -0.39 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | -0.39 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.39 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.39 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.39 |
| CDCA2 | cell division cycle associated 2 | -0.39 |
| PCLAF | PCNA clamp associated factor | -0.39 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.38 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.38 |
| JUN | jun proto-oncogene | -0.38 |
| HECA | headcase homolog (Drosophila) | -0.38 |
| PRR5 | proline rich 5 (renal) | -0.38 |
| METTL17 | methyltransferase like 17 | -0.38 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.38 |
| KIF20A | kinesin family member 20A | -0.38 |
| MEF2A | myocyte enhancer factor 2A | -0.38 |
| BTG3 | BTG family, member 3 | -0.37 |
| AURKB | aurora kinase B | -0.37 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.37 |
| LRR1 | leucine rich repeat protein 1 | -0.37 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.37 |
| KIF22 | kinesin family member 22 | -0.37 |
| CLSPN | claspin | -0.36 |
| SNX24 | sorting nexin 24 | -0.36 |
| NANP | N-acetylneuraminic acid phosphatase | -0.36 |
| NCAM1 | neural cell adhesion molecule 1 | -0.36 |
| ZNF101 | zinc finger protein 101 | -0.36 |
| ZNF180 | zinc finger protein 180 | -0.36 |
| CCDC88A | coiled-coil domain containing 88A | -0.36 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.36 |
| ATP13A2 | ATPase type 13A2 | -0.36 |
| TK1 | thymidine kinase 1, soluble | -0.36 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.35 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.35 |
| KIF11 | kinesin family member 11 | -0.35 |
| GTPBP8 | GTP-binding protein 8 (putative) | -0.35 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -0.35 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.35 |
| CDK6 | cyclin-dependent kinase 6 | -0.35 |
| CDK5RAP1 | CDK5 regulatory subunit associated protein 1 | -0.35 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.34 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.34 |
| TPX2 | TPX2, microtubule-associated | -0.34 |
| CCDC170 | coiled-coil domain containing 170 | -0.34 |
| FBXO33 | F-box protein 33 | -0.34 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | -0.34 |
