| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dabrafenib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.106934 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.103337 |
| CDH13 | cadherin 13 | 0.100505 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0943191 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0905994 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0874768 |
| FLNA | filamin A, alpha | 0.0817353 |
| LOXL2 | lysyl oxidase-like 2 | 0.0783638 |
| FLNB | filamin B, beta | 0.0595268 |
| ASPH | aspartate beta-hydroxylase | 0.0590212 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0572349 |
| EFNA5 | ephrin-A5 | 0.0563087 |
| SEPTIN9 | septin 9 | 0.0541762 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0514971 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.051416 |
| CD44 | CD44 molecule (Indian blood group) | 0.0508448 |
| CALR | calreticulin | 0.0507867 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0498864 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0497734 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0494114 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0490243 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0486705 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0480661 |
| PLEC | plectin | 0.0464766 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0464468 |
| CANX | calnexin | 0.0460506 |
| FSTL1 | follistatin-like 1 | 0.0456138 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0444124 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0431057 |
| TPM3 | tropomyosin 3 | 0.0428538 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0424602 |
| APP | amyloid beta (A4) precursor protein | 0.0423374 |
| EGFR | epidermal growth factor receptor | 0.0419478 |
| DSPP | dentin sialophosphoprotein | 0.0414116 |
| MCL1 | myeloid cell leukemia 1 | 0.03846 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0374141 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0373597 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0366786 |
| L1CAM | L1 cell adhesion molecule | 0.0363536 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0363415 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0348366 |
| NAV2 | neuron navigator 2 | 0.0347893 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0342084 |
| AHNAK | AHNAK nucleoprotein | 0.0341164 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0313745 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0312092 |
| MYO10 | myosin X | 0.0309449 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0309139 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0305215 |
| HDAC9 | histone deacetylase 9 | 0.0303606 |
| THBS2 | thrombospondin 2 | 0.0301837 |
| TMSB4X | thymosin beta 4, X-linked | 0.0301328 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0292421 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0286522 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0285864 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0284036 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0282525 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0270338 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.027011 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0269489 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0268401 |
| FAT1 | FAT atypical cadherin 1 | 0.026698 |
| RPL19 | ribosomal protein L19 | 0.0265612 |
| SMAD3 | SMAD family member 3 | 0.0264301 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0263753 |
| PRKCE | protein kinase C, epsilon | 0.0260755 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0259614 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0256035 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0254738 |
| STC1 | stanniocalcin 1 | 0.024934 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0247764 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0246635 |
| MSN | moesin | 0.024532 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0244564 |
| DNMBP | dynamin binding protein | 0.0239059 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0237307 |
| COL5A1 | collagen, type V, alpha 1 | 0.0237023 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0232501 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0230764 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0228649 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0225077 |
| RNF213 | ring finger protein 213 | 0.0219944 |
| SLFN5 | schlafen family member 5 | 0.0217821 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0217761 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0211406 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0211228 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0210049 |
| RND3 | Rho family GTPase 3 | 0.0209286 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0207538 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0206869 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0206177 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0204684 |
| PODXL | podocalyxin-like | 0.0203899 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0203733 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0203277 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0199484 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0199202 |
| COL3A1 | collagen, type III, alpha 1 | 0.0198693 |
| SET | SET nuclear proto-oncogene | 0.0197853 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0196256 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.297059 |
| TMSB10 | thymosin beta 10 | -0.193696 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.127244 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.126453 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.123435 |
| LOX | lysyl oxidase | -0.110523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.103169 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0775656 |
| COL1A2 | collagen, type I, alpha 2 | -0.0757234 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0685098 |
| SUCNR1 | succinate receptor 1 | -0.0684524 |
| FBN1 | fibrillin 1 | -0.0666416 |
| HLA-B | major histocompatibility complex, class I, B | -0.0621771 |
| POTEF | POTE ankyrin domain family, member F | -0.0619855 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0585048 |
| LMNA | lamin A/C | -0.0580623 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0559575 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0551036 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0537053 |
| B2M | beta-2-microglobulin | -0.0536877 |
| MT2A | metallothionein 2A | -0.0534665 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0531615 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0483077 |
| PLAT | plasminogen activator, tissue | -0.046285 |
| MYADM | myeloid-associated differentiation marker | -0.0457148 |
| MX2 | MX dynamin-like GTPase 2 | -0.0455772 |
| MEIS2 | Meis homeobox 2 | -0.0455285 |
| FN1 | fibronectin 1 | -0.0443227 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0440418 |
| S100A6 | S100 calcium binding protein A6 | -0.0429681 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0419605 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0394651 |
| NDRG1 | N-myc downstream regulated 1 | -0.0382734 |
| PTMA | prothymosin, alpha | -0.0377107 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0367779 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0363341 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0362761 |
| PFN1 | profilin 1 | -0.0359244 |
| S100A10 | S100 calcium binding protein A10 | -0.0355746 |
| MT1X | metallothionein 1X | -0.0343326 |
| FTL | ferritin, light polypeptide | -0.0342988 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0342219 |
| TAGLN2 | transgelin 2 | -0.03397 |
| CD99 | CD99 molecule | -0.0326468 |
| UBC | ubiquitin C | -0.031572 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0313486 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0305809 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0304689 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0299132 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0297015 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.029544 |
| FRMD5 | FERM domain containing 5 | -0.0284712 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0282195 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0273753 |
| S100A4 | S100 calcium binding protein A4 | -0.0266713 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0263851 |
| HLA-C | major histocompatibility complex, class I, C | -0.0248514 |
| MAP1B | microtubule-associated protein 1B | -0.0243283 |
| CSTB | cystatin B (stefin B) | -0.0230091 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0229455 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0225009 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.022311 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0222091 |
| GNAS | GNAS complex locus | -0.0221945 |
| KIFAP3 | kinesin-associated protein 3 | -0.0220011 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0216321 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0213031 |
| FNDC3A | fibronectin type III domain containing 3A | -0.021136 |
| S100A9 | S100 calcium binding protein A9 | -0.02093 |
| COL1A1 | collagen, type I, alpha 1 | -0.0206833 |
| DCLK2 | doublecortin-like kinase 2 | -0.0206375 |
| RBM25 | RNA binding motif protein 25 | -0.0201166 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0199864 |
| JAZF1 | JAZF zinc finger 1 | -0.0197592 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0194187 |
| TAPBP | TAP binding protein (tapasin) | -0.0192217 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0191693 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0187123 |
| CCND1 | cyclin D1 | -0.0186989 |
| RPL35A | ribosomal protein L35a | -0.0186842 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0184861 |
| WTAP | Wilms tumor 1 associated protein | -0.0183845 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0182711 |
| CD109 | CD109 molecule | -0.0182301 |
| SBF2 | SET binding factor 2 | -0.0182156 |
| RIGI | RNA sensor RIG-I | -0.0181697 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0180518 |
| GOLGA4 | golgin A4 | -0.0178071 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0177459 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0176174 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0175897 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0175286 |
| PRRX1 | paired related homeobox 1 | -0.0174421 |
| TPM1 | tropomyosin 1 (alpha) | -0.0170093 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0169113 |
| INSIG1 | insulin induced gene 1 | -0.0168526 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0168104 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0167988 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0161853 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0161693 |
