Dabrafenib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dabrafenib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.249568
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.202775
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.165633
HMGA2 high mobility group AT-hook 2 0.139679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.138228
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.131928
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.131102
YAP1 Yes-associated protein 1 0.0832157
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0829911
RAB7A RAB7A, member RAS oncogene family 0.0758688
ASPH aspartate beta-hydroxylase 0.072916
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0648245
ZSWIM6 zinc finger, SWIM-type containing 6 0.0636023
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0630282
MACF1 microtubule-actin crosslinking factor 1 0.0600942
JMJD1C jumonji domain containing 1C 0.0589528
TPI1 triosephosphate isomerase 1 0.0585487
ADIPOR2 adiponectin receptor 2 0.0583434
RPL19 ribosomal protein L19 0.0579475
AKAP12 A kinase (PRKA) anchor protein 12 0.057239
CSNK1A1 casein kinase 1, alpha 1 0.0558362
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0552636
EHBP1 EH domain binding protein 1 0.0537443
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0533319
TPM3 tropomyosin 3 0.0530732
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0520538
RRM2 ribonucleotide reductase M2 0.0513353
NLGN1 neuroligin 1 0.0497268
HSPA8 heat shock 70kDa protein 8 0.0494836
CALR calreticulin 0.0473889
DST dystonin 0.0468256
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0464552
INTS6 integrator complex subunit 6 0.0461762
CMIP c-Maf inducing protein 0.0445687
IPO7 importin 7 0.0440393
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0430141
EEF1G eukaryotic translation elongation factor 1 gamma 0.0427347
OSBPL8 oxysterol binding protein-like 8 0.042581
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0412858
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0395309
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0392299
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0383568
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0381516
P4HB prolyl 4-hydroxylase, beta polypeptide 0.035914
DDIT3 DNA-damage-inducible transcript 3 0.0357414
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0355764
ANKRD17 ankyrin repeat domain 17 0.0350913
ERRFI1 ERBB receptor feedback inhibitor 1 0.0350255
GJA1 gap junction protein, alpha 1, 43kDa 0.0341853
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0340939
PCDH7 protocadherin 7 0.033904
TRIO trio Rho guanine nucleotide exchange factor 0.0338966
AREG amphiregulin 0.0336919
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0332835
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0329662
LOC102724023 ES1 protein homolog, mitochondrial 0.0329252
FAT1 FAT atypical cadherin 1 0.0327406
MCL1 myeloid cell leukemia 1 0.032675
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0320876
CUX1 cut-like homeobox 1 0.0320642
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0320488
DOCK1 dedicator of cytokinesis 1 0.0318481
WNK1 WNK lysine deficient protein kinase 1 0.0318023
ASXL2 additional sex combs like transcriptional regulator 2 0.0314152
BRD2 bromodomain containing 2 0.0312685
LPP LIM domain containing preferred translocation partner in lipoma 0.0312123
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311909
RASAL2 RAS protein activator like 2 0.0310751
HSPH1 heat shock 105kDa/110kDa protein 1 0.0310526
GOLGB1 golgin B1 0.0310468
DENND5A DENN/MADD domain containing 5A 0.0310416
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0308916
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0302473
SETX senataxin 0.0302419
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.030136
FNIP1 folliculin interacting protein 1 0.0299788
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0299626
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0299138
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0298247
EGR1 early growth response 1 0.029549
PDCD6 programmed cell death 6 0.0290555
AFF4 AF4/FMR2 family, member 4 0.0290102
SPATS2 spermatogenesis associated, serine-rich 2 0.0288585
RNF213 ring finger protein 213 0.0287971
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285049
MAGEA4 melanoma antigen family A4 0.027772
FLNA filamin A, alpha 0.0276979
MYH9 myosin, heavy chain 9, non-muscle 0.0276597
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0274543
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0273675
PDGFC platelet derived growth factor C 0.0271739
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.026686
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0266832
EZR ezrin 0.0266717
RPL7 ribosomal protein L7 0.0266046
MSRB3 methionine sulfoxide reductase B3 0.0265635
XPOT exportin, tRNA 0.0265044
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0264463
TUBA1B tubulin, alpha 1b 0.0263583
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0263293

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137348
TMSB10 thymosin beta 10 -0.0925293
RPS27A ribosomal protein S27a -0.0592534
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0532578
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0513136
MYL12B myosin, light chain 12B, regulatory -0.0484176
CXADR coxsackie virus and adenovirus receptor -0.0466454
MGAT4C MGAT4 family, member C -0.0459938
AHNAK AHNAK nucleoprotein -0.0442761
NEK7 NIMA-related kinase 7 -0.0421463
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0410005
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0405575
RPS21 ribosomal protein S21 -0.0366809
ATP5F1B ATP synthase F1 subunit beta -0.0364562
RPL23 ribosomal protein L23 -0.0361995
RPL35A ribosomal protein L35a -0.0358688
ZNF217 zinc finger protein 217 -0.0351622
ADGRG6 adhesion G protein-coupled receptor G6 -0.0344727
PTMA prothymosin, alpha -0.034074
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0338182
WDR45B WD repeat domain 45B -0.0328391
RPS24 ribosomal protein S24 -0.031648
KDM3A lysine (K)-specific demethylase 3A -0.0313489
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.030966
CNRIP1 cannabinoid receptor interacting protein 1 -0.0297931
RPL38 ribosomal protein L38 -0.0294765
FUS FUS RNA binding protein -0.0294631
THOC2 THO complex 2 -0.0291918
PNISR PNN-interacting serine/arginine-rich protein -0.0280203
RPL34 ribosomal protein L34 -0.0273214
RPL8 ribosomal protein L8 -0.0270865
ANKRD28 ankyrin repeat domain 28 -0.027004
TNPO1 transportin 1 -0.0269504
PFN1 profilin 1 -0.026518
RPLP1 ribosomal protein, large, P1 -0.0264135
ARHGAP12 Rho GTPase activating protein 12 -0.0263924
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0262767
WSB1 WD repeat and SOCS box containing 1 -0.0261642
XPO1 exportin 1 -0.0261338
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0261275
MARCHF6 membrane associated ring-CH-type finger 6 -0.0256543
MATR3 matrin 3 -0.0254379
ECT2 epithelial cell transforming 2 -0.0250291
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0249982
MED13L mediator complex subunit 13-like -0.024669
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0243611
RPLP2 ribosomal protein, large, P2 -0.0242913
RPS15 ribosomal protein S15 -0.0237006
TMEM123 transmembrane protein 123 -0.0236171
ZBTB20 zinc finger and BTB domain containing 20 -0.0231335
PUM2 pumilio RNA-binding family member 2 -0.0230724
UBC ubiquitin C -0.0229048
OXR1 oxidation resistance 1 -0.0228918
ZNF292 zinc finger protein 292 -0.0227872
KLHL24 kelch-like family member 24 -0.0225631
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0225467
SMYD3 SET and MYND domain containing 3 -0.0223626
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0222104
THOC1 THO complex 1 -0.022102
H1-0 H1.0 linker histone -0.0220858
ZFR zinc finger RNA binding protein -0.0220154
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0218681
BTG3 BTG family, member 3 -0.021724
RPL32 ribosomal protein L32 -0.0214566
RPL26 ribosomal protein L26 -0.0214458
CCNI cyclin I -0.0214191
RPS6 ribosomal protein S6 -0.0212988
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0208686
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.02064
CPOX coproporphyrinogen oxidase -0.020629
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0206272
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0206225
RBM25 RNA binding motif protein 25 -0.0205335
GASK1B golgi associated kinase 1B -0.0204
RAD21 RAD21 homolog (S. pombe) -0.0203513
RNF13 ring finger protein 13 -0.0202934
CENPE centromere protein E, 312kDa -0.0202578
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0201289
CEP95 centrosomal protein 95kDa -0.0199574
VCL vinculin -0.0199387
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0197729
MIS18BP1 MIS18 binding protein 1 -0.019753
YBX3 Y box binding protein 3 -0.0197506
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0196377
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0196342
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0191796
CLDN1 claudin 1 -0.0190472
EDN1 endothelin 1 -0.0190102
BRWD1 bromodomain and WD repeat domain containing 1 -0.0187836
RB1CC1 RB1-inducible coiled-coil 1 -0.018775
SINHCAF SIN3-HDAC complex associated factor -0.0185963
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0184343
NKTR natural killer cell triggering receptor -0.018422
IPMK inositol polyphosphate multikinase -0.0183852
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0182239
RPS5 ribosomal protein S5 -0.0178
RPS13 ribosomal protein S13 -0.0177312
KPNB1 karyopherin (importin) beta 1 -0.017539
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0172918
RPS19 ribosomal protein S19 -0.0171371