| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.163059 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.146792 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.119702 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.115077 |
| TLE4 | transducin-like enhancer of split 4 | 0.114639 |
| EXT1 | exostosin glycosyltransferase 1 | 0.111888 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0919327 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0870519 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0771092 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0742285 |
| VIM | vimentin | 0.0731032 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0727864 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0717316 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.071112 |
| MCL1 | myeloid cell leukemia 1 | 0.0707114 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0706626 |
| FMN1 | formin 1 | 0.0677095 |
| SEPTIN9 | septin 9 | 0.0675375 |
| STC1 | stanniocalcin 1 | 0.0618512 |
| VMP1 | vacuole membrane protein 1 | 0.0585555 |
| TPM1 | tropomyosin 1 (alpha) | 0.0580312 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0570621 |
| FERMT2 | fermitin family member 2 | 0.0568902 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0540503 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0529532 |
| PLAT | plasminogen activator, tissue | 0.052093 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0516506 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0514254 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0511011 |
| VGF | VGF nerve growth factor inducible | 0.0494188 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0454382 |
| GLCCI1 | glucocorticoid induced 1 | 0.0440685 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0438306 |
| PCBP2 | poly(rC) binding protein 2 | 0.0432887 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0424831 |
| RPL19 | ribosomal protein L19 | 0.0417962 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0412043 |
| TOP1 | topoisomerase (DNA) I | 0.0410441 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0395182 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0379523 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0378543 |
| LIMA1 | LIM domain and actin binding 1 | 0.0377318 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0366454 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0366103 |
| AFF3 | AF4/FMR2 family, member 3 | 0.036387 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0357577 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0357299 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0357238 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0355043 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0354374 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0354173 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.034813 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0347193 |
| HMGA2 | high mobility group AT-hook 2 | 0.0346352 |
| MYO1E | myosin IE | 0.0342943 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0342687 |
| ANGPTL4 | angiopoietin-like 4 | 0.033565 |
| AEBP2 | AE binding protein 2 | 0.0335267 |
| CDH13 | cadherin 13 | 0.0331429 |
| SMAD3 | SMAD family member 3 | 0.0327342 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0325314 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0322502 |
| HPCAL1 | hippocalcin-like 1 | 0.0315594 |
| DST | dystonin | 0.0311505 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0309474 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0307552 |
| SETBP1 | SET binding protein 1 | 0.0304892 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0302298 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0298019 |
| LOXL2 | lysyl oxidase-like 2 | 0.0292913 |
| AMOTL1 | angiomotin like 1 | 0.0290252 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0290154 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0290153 |
| PDE10A | phosphodiesterase 10A | 0.0289236 |
| TPR | translocated promoter region, nuclear basket protein | 0.0285174 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0280054 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0278934 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0276291 |
| ACTN1 | actinin, alpha 1 | 0.027594 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0270785 |
| MED13 | mediator complex subunit 13 | 0.0270671 |
| ACLY | ATP citrate lyase | 0.0267781 |
| FLNB | filamin B, beta | 0.0267694 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0266584 |
| HOMER1 | homer scaffolding protein 1 | 0.0262171 |
| CCDC57 | coiled-coil domain containing 57 | 0.0262005 |
| RPS12 | ribosomal protein S12 | 0.0257826 |
| RCOR1 | REST corepressor 1 | 0.025407 |
| FHL2 | four and a half LIM domains 2 | 0.0251666 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0250551 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0249791 |
| TPM4 | tropomyosin 4 | 0.0247441 |
| INTS6 | integrator complex subunit 6 | 0.024467 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0242835 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0242311 |
| RPL7 | ribosomal protein L7 | 0.0240867 |
| SYNPO2 | synaptopodin 2 | 0.0240107 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0239239 |
| GAB2 | GRB2-associated binding protein 2 | 0.0237802 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0231009 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.279593 |
| LSAMP | limbic system-associated membrane protein | -0.115453 |
| COL1A1 | collagen, type I, alpha 1 | -0.106061 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101927 |
| MEIS2 | Meis homeobox 2 | -0.0966535 |
| PTMA | prothymosin, alpha | -0.0812913 |
| SYT1 | synaptotagmin I | -0.0750535 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0551255 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0489996 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0486571 |
| RPL38 | ribosomal protein L38 | -0.0481121 |
| LPIN1 | lipin 1 | -0.0467071 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0459166 |
| COL3A1 | collagen, type III, alpha 1 | -0.0459028 |
| RPS24 | ribosomal protein S24 | -0.0458406 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0457677 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0432817 |
| RPL34 | ribosomal protein L34 | -0.0394658 |
| TMSB10 | thymosin beta 10 | -0.0386907 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0385582 |
| CRH | corticotropin releasing hormone | -0.0379395 |
| RPL35A | ribosomal protein L35a | -0.0376087 |
| GNAS | GNAS complex locus | -0.0344927 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0338296 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0338002 |
| RPS6 | ribosomal protein S6 | -0.0329695 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0324781 |
| NREP | neuronal regeneration related protein | -0.0319181 |
| RPLP1 | ribosomal protein, large, P1 | -0.0310831 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0307067 |
| CADM2 | cell adhesion molecule 2 | -0.0300265 |
| WDR45B | WD repeat domain 45B | -0.0298113 |
| ZNF804A | zinc finger protein 804A | -0.0297611 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0292891 |
| AHNAK | AHNAK nucleoprotein | -0.0292504 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0291578 |
| H3-3B | H3.3 histone B | -0.0290829 |
| FNBP1 | formin binding protein 1 | -0.0286134 |
| RPL23 | ribosomal protein L23 | -0.0284824 |
| S100A9 | S100 calcium binding protein A9 | -0.028267 |
| MAP1B | microtubule-associated protein 1B | -0.0272677 |
| PCDH9 | protocadherin 9 | -0.0264525 |
| SEPTIN2 | septin 2 | -0.0259329 |
| RPS21 | ribosomal protein S21 | -0.0258375 |
| RPL32 | ribosomal protein L32 | -0.0252189 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0242843 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0237557 |
| MATR3 | matrin 3 | -0.0226015 |
| FHIT | fragile histidine triad | -0.0225775 |
| USP3 | ubiquitin specific peptidase 3 | -0.0223373 |
| FRMD4A | FERM domain containing 4A | -0.0215236 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213445 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0206792 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0205214 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0202706 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0200077 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0198492 |
| IER3 | immediate early response 3 | -0.0196615 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0194281 |
| FOXK2 | forkhead box K2 | -0.0192991 |
| ACTG1 | actin gamma 1 | -0.0192501 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0190482 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0189848 |
| AOPEP | aminopeptidase O (putative) | -0.0185459 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0182855 |
| ZNF292 | zinc finger protein 292 | -0.0178418 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0177487 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0174225 |
| RBM20 | RNA binding motif protein 20 | -0.0173603 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0173108 |
| ANGPT1 | angiopoietin 1 | -0.0172553 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0171502 |
| RPS27A | ribosomal protein S27a | -0.0170983 |
| RFX7 | regulatory factor X, 7 | -0.0170473 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0169771 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0169664 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0166421 |
| LMNA | lamin A/C | -0.0166295 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.016592 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0165553 |
| NEK7 | NIMA-related kinase 7 | -0.0165424 |
| CDC27 | cell division cycle 27 | -0.0165192 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0163057 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0161848 |
| RPS19 | ribosomal protein S19 | -0.0161732 |
| PHOX2B | paired-like homeobox 2b | -0.0161174 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.016076 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.016042 |
| TULP4 | tubby like protein 4 | -0.0160162 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0160008 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0158761 |
| PLCB4 | phospholipase C, beta 4 | -0.0157699 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0157628 |
| CENPF | centromere protein F, 350/400kDa | -0.0157323 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0157144 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0156201 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0154542 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0154324 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.01543 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.015273 |
