| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dabrafenib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.493493 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.411133 |
| COL6A3 | collagen, type VI, alpha 3 | 0.218582 |
| VIM | vimentin | 0.194837 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.152527 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127118 |
| LOXL2 | lysyl oxidase-like 2 | 0.123089 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.112839 |
| CALR | calreticulin | 0.105254 |
| CDH13 | cadherin 13 | 0.101228 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0982323 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0851917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0773594 |
| STC1 | stanniocalcin 1 | 0.0711817 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0695758 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0689846 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0634234 |
| PLEC | plectin | 0.0598358 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.056748 |
| ENO1 | enolase 1, (alpha) | 0.0537055 |
| MYO10 | myosin X | 0.0528052 |
| CANX | calnexin | 0.0505472 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0439478 |
| FLNA | filamin A, alpha | 0.041239 |
| RPL19 | ribosomal protein L19 | 0.0411411 |
| APP | amyloid beta (A4) precursor protein | 0.0405967 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0402833 |
| GOLGB1 | golgin B1 | 0.0399583 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0385424 |
| ASPH | aspartate beta-hydroxylase | 0.0379613 |
| CD44 | CD44 molecule (Indian blood group) | 0.0377223 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0375779 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0375778 |
| CTSB | cathepsin B | 0.0366995 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0364473 |
| CLMP | CXADR-like membrane protein | 0.0362819 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361048 |
| HYOU1 | hypoxia up-regulated 1 | 0.0354029 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0351715 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0345302 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0344455 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0342418 |
| FBN1 | fibrillin 1 | 0.0328044 |
| RPL7 | ribosomal protein L7 | 0.0325783 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0323695 |
| ECE1 | endothelin converting enzyme 1 | 0.0312555 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0304702 |
| POSTN | periostin, osteoblast specific factor | 0.0302959 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0301551 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0284519 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0280649 |
| HDLBP | high density lipoprotein binding protein | 0.027983 |
| FAM107B | family with sequence similarity 107, member B | 0.0275255 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0269675 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0259187 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0259066 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0258173 |
| LDHA | lactate dehydrogenase A | 0.0256604 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0256528 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0252429 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0247755 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0243781 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0243215 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0242378 |
| INHBA | inhibin, beta A | 0.0238685 |
| TMSB4X | thymosin beta 4, X-linked | 0.0237121 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0234771 |
| FAT1 | FAT atypical cadherin 1 | 0.0233056 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0232225 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0224693 |
| MCL1 | myeloid cell leukemia 1 | 0.0223814 |
| COL3A1 | collagen, type III, alpha 1 | 0.0219665 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0214872 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0214765 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.021431 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0213046 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0212641 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0211753 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0210301 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0209205 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0208699 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.020575 |
| SQSTM1 | sequestosome 1 | 0.0205178 |
| JUN | jun proto-oncogene | 0.0204396 |
| GLIS3 | GLIS family zinc finger 3 | 0.0200059 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.019978 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0198687 |
| CALU | calumenin | 0.019583 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0195675 |
| LRRC59 | leucine rich repeat containing 59 | 0.0192455 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0190397 |
| FMNL2 | formin-like 2 | 0.0189657 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0187376 |
| HLA-E | major histocompatibility complex, class I, E | 0.0186715 |
| SDC2 | syndecan 2 | 0.0186077 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0185217 |
| SP100 | SP100 nuclear antigen | 0.0181445 |
| MSN | moesin | 0.0180441 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0178038 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0177499 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.191687 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112793 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.101836 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0696589 |
| COL1A2 | collagen, type I, alpha 2 | -0.0450618 |
| FTL | ferritin, light polypeptide | -0.0418732 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0413303 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379858 |
| LOX | lysyl oxidase | -0.031914 |
| MT2A | metallothionein 2A | -0.0310937 |
| RPS6 | ribosomal protein S6 | -0.0271985 |
| PTMA | prothymosin, alpha | -0.0271114 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0256744 |
| TMSB10 | thymosin beta 10 | -0.0249638 |
| PFN1 | profilin 1 | -0.023547 |
| IER3 | immediate early response 3 | -0.0231843 |
| MT1X | metallothionein 1X | -0.0228845 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.022682 |
| NDRG1 | N-myc downstream regulated 1 | -0.0211636 |
| RPL35A | ribosomal protein L35a | -0.0207567 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0204728 |
| ZNF292 | zinc finger protein 292 | -0.0203737 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0195641 |
| PRELID2 | PRELI domain containing 2 | -0.0193543 |
| S100A9 | S100 calcium binding protein A9 | -0.0187282 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0183791 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0182766 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0173422 |
| CALD1 | caldesmon 1 | -0.0166169 |
| ATP13A3 | ATPase type 13A3 | -0.0161602 |
| PALLD | palladin, cytoskeletal associated protein | -0.0161382 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.016012 |
| TAPBP | TAP binding protein (tapasin) | -0.0149358 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0147887 |
| PRR16 | proline rich 16 | -0.0141698 |
| RTN4 | reticulon 4 | -0.014135 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0140883 |
| PDE10A | phosphodiesterase 10A | -0.0137843 |
| OSMR | oncostatin M receptor | -0.0137707 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0137518 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0137032 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0136312 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0134778 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.013229 |
| HAS2 | hyaluronan synthase 2 | -0.0130685 |
| HLA-B | major histocompatibility complex, class I, B | -0.0129077 |
| RNF220 | ring finger protein 220 | -0.0128925 |
| TFG | TRK-fused gene | -0.0128803 |
| FBXO32 | F-box protein 32 | -0.0123247 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0122962 |
| EHD2 | EH-domain containing 2 | -0.0122751 |
| RPS21 | ribosomal protein S21 | -0.0122593 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0121649 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0121625 |
| RPLP2 | ribosomal protein, large, P2 | -0.0118747 |
| TPM1 | tropomyosin 1 (alpha) | -0.0118328 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0117799 |
| NREP | neuronal regeneration related protein | -0.0115683 |
| QKI | QKI, KH domain containing, RNA binding | -0.0115534 |
| PHF21A | PHD finger protein 21A | -0.0114962 |
| SQLE | squalene epoxidase | -0.0113631 |
| RPS13 | ribosomal protein S13 | -0.0113058 |
| GNAS | GNAS complex locus | -0.0112698 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0111848 |
| POTEF | POTE ankyrin domain family, member F | -0.011144 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0110418 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0108264 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0108148 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0107751 |
| STK38L | serine/threonine kinase 38 like | -0.0107225 |
| INSIG2 | insulin induced gene 2 | -0.010672 |
| WTAP | Wilms tumor 1 associated protein | -0.0106339 |
| TMEM165 | transmembrane protein 165 | -0.0105708 |
| RBM39 | RNA binding motif protein 39 | -0.0105169 |
| SBF2 | SET binding factor 2 | -0.010316 |
| NKTR | natural killer cell triggering receptor | -0.0102952 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0101707 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0100893 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0100495 |
| RIC1 | RAB6A GEF complex partner 1 | -0.0100086 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0100014 |
| CD109 | CD109 molecule | -0.0099705 |
| CCDC80 | coiled-coil domain containing 80 | -0.00994533 |
| VEGFC | vascular endothelial growth factor C | -0.00988925 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.00969748 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.00956348 |
| MX2 | MX dynamin-like GTPase 2 | -0.00952869 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.00946731 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00938049 |
| WDR45B | WD repeat domain 45B | -0.0092681 |
| CADM1 | cell adhesion molecule 1 | -0.00923862 |
| RNF145 | ring finger protein 145 | -0.00922012 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.00914146 |
| RAB6A | RAB6A, member RAS oncogene family | -0.00910611 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00908372 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0089667 |
| USP3 | ubiquitin specific peptidase 3 | -0.00895485 |
| THOC2 | THO complex 2 | -0.00892785 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00892621 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.00891277 |
