| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.496707 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.310236 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.160394 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0952518 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0928859 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0732344 |
| SVIL | supervillin | 0.0720387 |
| DSPP | dentin sialophosphoprotein | 0.0703944 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0679033 |
| MT2A | metallothionein 2A | 0.0605925 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0572851 |
| TF | transferrin | 0.053984 |
| AHSG | alpha-2-HS-glycoprotein | 0.053267 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0517942 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.04984 |
| FAM107B | family with sequence similarity 107, member B | 0.048137 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0441486 |
| FOXP1 | forkhead box P1 | 0.0432389 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0429072 |
| RPS12 | ribosomal protein S12 | 0.042433 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416134 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0393676 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0393372 |
| FAT1 | FAT atypical cadherin 1 | 0.0387551 |
| RPS8 | ribosomal protein S8 | 0.0370879 |
| C3 | complement component 3 | 0.0367712 |
| HMGA1 | high mobility group AT-hook 1 | 0.036326 |
| MCL1 | myeloid cell leukemia 1 | 0.0362508 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0355632 |
| RPL19 | ribosomal protein L19 | 0.0345864 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0333089 |
| RPL7 | ribosomal protein L7 | 0.0332382 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0330868 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0325389 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.032191 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0321308 |
| RPL11 | ribosomal protein L11 | 0.0314799 |
| RPL37A | ribosomal protein L37a | 0.0313177 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0298173 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0286645 |
| BCL2L1 | BCL2-like 1 | 0.0272945 |
| CTSB | cathepsin B | 0.0270299 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.025847 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0245806 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0244179 |
| KRT18 | keratin 18, type I | 0.0235927 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.022953 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0228726 |
| TPM4 | tropomyosin 4 | 0.0225557 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0224566 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0224431 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0212894 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0212424 |
| RPS17 | ribosomal protein S17 | 0.0211109 |
| TMSB10 | thymosin beta 10 | 0.0210148 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0207891 |
| DSTN | destrin (actin depolymerizing factor) | 0.0207398 |
| RPS6 | ribosomal protein S6 | 0.0206114 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0204189 |
| KYNU | kynureninase | 0.0203492 |
| SLC38A2 | solute carrier family 38, member 2 | 0.02001 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0199481 |
| SEPTIN9 | septin 9 | 0.0198963 |
| CPE | carboxypeptidase E | 0.0198842 |
| DUSP6 | dual specificity phosphatase 6 | 0.0198495 |
| RPL26 | ribosomal protein L26 | 0.019715 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0193228 |
| RPS3 | ribosomal protein S3 | 0.0191934 |
| RPL5 | ribosomal protein L5 | 0.0187188 |
| FN1 | fibronectin 1 | 0.0187123 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0185225 |
| RPL31 | ribosomal protein L31 | 0.0183143 |
| KLF6 | Kruppel-like factor 6 | 0.0181586 |
| RAI14 | retinoic acid induced 14 | 0.018108 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0180204 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0178766 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0178266 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0178019 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0170947 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0169562 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0167357 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0166716 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.016666 |
| RPLP0 | ribosomal protein, large, P0 | 0.016612 |
| NHSL1 | NHS-like 1 | 0.0165116 |
| ACTN4 | actinin, alpha 4 | 0.0160687 |
| RPS25 | ribosomal protein S25 | 0.0160103 |
| PLEC | plectin | 0.0159869 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0159866 |
| RACK1 | receptor for activated C kinase 1 | 0.0158688 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0156639 |
| ASPH | aspartate beta-hydroxylase | 0.0156388 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0155568 |
| ITGA6 | integrin, alpha 6 | 0.0155436 |
| FERMT1 | fermitin family member 1 | 0.0152686 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0151871 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0151342 |
| RPL3 | ribosomal protein L3 | 0.0150985 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0150601 |
| PEG3 | paternally expressed 3 | 0.0149774 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.0752123 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0658745 |
| GPC6 | glypican 6 | -0.0556409 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0479017 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.045024 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0354432 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.033374 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0331428 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0310963 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0296681 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0288169 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0274803 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0266057 |
| NPAS2 | neuronal PAS domain protein 2 | -0.025901 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0256628 |
| PRELID2 | PRELI domain containing 2 | -0.0213881 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0211394 |
| TMEM123 | transmembrane protein 123 | -0.0210674 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0209635 |
| RBM39 | RNA binding motif protein 39 | -0.0206831 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0194808 |
| H1-0 | H1.0 linker histone | -0.0193705 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0192891 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0189026 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0187952 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0186767 |
| AHNAK | AHNAK nucleoprotein | -0.0185102 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0183525 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0182447 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0182228 |
| VCL | vinculin | -0.018095 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0175689 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.017074 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.016997 |
| PTCHD4 | patched domain containing 4 | -0.0168818 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0166214 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0165186 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0151586 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0150447 |
| OSMR | oncostatin M receptor | -0.0149594 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0148762 |
| MALT1 | MALT1 paracaspase | -0.0147905 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0147026 |
| ATP10A | ATPase, class V, type 10A | -0.0142882 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0142484 |
| SDC4 | syndecan 4 | -0.014187 |
| ZNF638 | zinc finger protein 638 | -0.0136506 |
| ZNF292 | zinc finger protein 292 | -0.0136384 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0136014 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0135907 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0134097 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0132079 |
| ARFGEF3 | ARFGEF family member 3 | -0.0131445 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0130785 |
| TRIM26 | tripartite motif containing 26 | -0.0130309 |
| ITGA1 | integrin, alpha 1 | -0.0127981 |
| PHF21A | PHD finger protein 21A | -0.0127952 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0123706 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0123626 |
| FOXN3 | forkhead box N3 | -0.012304 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0121918 |
| NFIA | nuclear factor I/A | -0.0121744 |
| A2M | alpha-2-macroglobulin | -0.0121623 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0121607 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0120844 |
| CDK19 | cyclin-dependent kinase 19 | -0.0120826 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0120161 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0119639 |
| AFDN | afadin, adherens junction formation factor | -0.0119144 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0119047 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.011818 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0116915 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0115008 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0113588 |
| DST | dystonin | -0.0112768 |
| RUNX1 | runt-related transcription factor 1 | -0.0110195 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0110099 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0110047 |
| RIGI | RNA sensor RIG-I | -0.0109486 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0108507 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0108447 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.010648 |
| RBM25 | RNA binding motif protein 25 | -0.0105041 |
| TNS3 | tensin 3 | -0.0103772 |
| TMEM51 | transmembrane protein 51 | -0.0102413 |
| RPS27A | ribosomal protein S27a | -0.0101647 |
| MSI2 | musashi RNA-binding protein 2 | -0.0101178 |
| TBCK | TBC1 domain containing kinase | -0.0101132 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0100869 |
| FUS | FUS RNA binding protein | -0.0100132 |
| SELENOP | selenoprotein P | -0.00998691 |
| DSCAM | Down syndrome cell adhesion molecule | -0.00997853 |
| HELZ | helicase with zinc finger | -0.00994882 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.00990805 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.00986834 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0098485 |
| VMP1 | vacuole membrane protein 1 | -0.00977032 |
| DOCK4 | dedicator of cytokinesis 4 | -0.00972823 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.00969149 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.00968145 |
