Dabrafenib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dabrafenib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.14626
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.142811
MYH9 myosin, heavy chain 9, non-muscle 0.132948
SPTBN1 spectrin, beta, non-erythrocytic 1 0.131007
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.123129
MUC17 mucin 17, cell surface associated 0.109297
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.107452
MBNL2 muscleblind-like splicing regulator 2 0.10569
APLP2 amyloid beta (A4) precursor-like protein 2 0.099536
RPL19 ribosomal protein L19 0.0978874
DSPP dentin sialophosphoprotein 0.0874047
RNF213 ring finger protein 213 0.0714438
SEPTIN9 septin 9 0.069932
MACC1 metastasis associated in colon cancer 1 0.0677792
LMO7 LIM domain 7 0.0671699
KRT18 keratin 18, type I 0.0654633
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0647646
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0619234
MYOF myoferlin 0.0616849
RPS12 ribosomal protein S12 0.0592765
MBNL1 muscleblind-like splicing regulator 1 0.0544499
PLEC plectin 0.0539848
PTPRK protein tyrosine phosphatase, receptor type, K 0.0538766
ACTN4 actinin, alpha 4 0.0534882
ASPH aspartate beta-hydroxylase 0.0531366
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0524565
AKAP13 A kinase (PRKA) anchor protein 13 0.0523491
LPP LIM domain containing preferred translocation partner in lipoma 0.0522387
SMAD3 SMAD family member 3 0.0517788
ZSWIM6 zinc finger, SWIM-type containing 6 0.047412
FAT1 FAT atypical cadherin 1 0.047218
FNDC3B fibronectin type III domain containing 3B 0.0471266
LCN2 lipocalin 2 0.0466562
TMC5 transmembrane channel-like 5 0.0466381
EEF1G eukaryotic translation elongation factor 1 gamma 0.0459267
PABPC1 poly(A) binding protein, cytoplasmic 1 0.042773
DSTN destrin (actin depolymerizing factor) 0.0423392
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0420528
EXT1 exostosin glycosyltransferase 1 0.0418862
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0412016
HSPA8 heat shock 70kDa protein 8 0.0407906
B2M beta-2-microglobulin 0.0393602
NFE2L1 nuclear factor, erythroid 2-like 1 0.0389302
NCEH1 neutral cholesterol ester hydrolase 1 0.0384224
DST dystonin 0.0382036
EEF2 eukaryotic translation elongation factor 2 0.0379907
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0376514
CALR calreticulin 0.0375153
GOLGB1 golgin B1 0.0357964
RPL7 ribosomal protein L7 0.0355356
KRT19 keratin 19, type I 0.0352192
LOC102724023 ES1 protein homolog, mitochondrial 0.0351536
FTL ferritin, light polypeptide 0.0350827
ATXN1 ataxin 1 0.0350527
KLF5 Kruppel-like factor 5 (intestinal) 0.034809
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0342663
PCBP2 poly(rC) binding protein 2 0.0341277
PDLIM5 PDZ and LIM domain 5 0.0337675
MPRIP myosin phosphatase Rho interacting protein 0.0337089
TMSB4X thymosin beta 4, X-linked 0.0336939
FLNA filamin A, alpha 0.0333621
SNX9 sorting nexin 9 0.0328666
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0325963
MACF1 microtubule-actin crosslinking factor 1 0.0323817
RPS3 ribosomal protein S3 0.0319209
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0317362
HYOU1 hypoxia up-regulated 1 0.0309725
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0306138
EZR ezrin 0.029856
TJP1 tight junction protein 1 0.0295924
SHB Src homology 2 domain containing adaptor protein B 0.0294089
TMF1 TATA element modulatory factor 1 0.0293666
LIMA1 LIM domain and actin binding 1 0.0293605
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0291805
ENO1 enolase 1, (alpha) 0.0291694
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0289926
SET SET nuclear proto-oncogene 0.0286191
NUMA1 nuclear mitotic apparatus protein 1 0.0284651
GDA guanine deaminase 0.0283015
EFNB2 ephrin-B2 0.0276619
SP100 SP100 nuclear antigen 0.0276322
BRD2 bromodomain containing 2 0.0275182
ANXA1 annexin A1 0.0274443
ANXA11 annexin A11 0.0271331
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0269156
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0265865
RBM47 RNA binding motif protein 47 0.0265452
CTNND1 catenin (cadherin-associated protein), delta 1 0.0265181
LASP1 LIM and SH3 protein 1 0.0263852
MYH14 myosin, heavy chain 14, non-muscle 0.0263538
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262522
NUPR1 nuclear protein, transcriptional regulator, 1 0.0259098
LRRC59 leucine rich repeat containing 59 0.0256385
CLDN4 claudin 4 0.0255384
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0254621
MCL1 myeloid cell leukemia 1 0.0254182
FLNB filamin B, beta 0.0253463
ATF5 activating transcription factor 5 0.0243531
RPS17 ribosomal protein S17 0.0240759
CEMIP2 cell migration inducing hyaluronidase 2 0.0240399

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.220281
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.160258
GMDS GDP-mannose 4,6-dehydratase -0.135183
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117466
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0854046
TMSB10 thymosin beta 10 -0.0788804
PTMA prothymosin, alpha -0.0783341
WDR45B WD repeat domain 45B -0.0767357
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.071801
AGR2 anterior gradient 2 -0.0697111
FGFR2 fibroblast growth factor receptor 2 -0.0678879
H1-0 H1.0 linker histone -0.0607507
S100A10 S100 calcium binding protein A10 -0.0584178
PDIA3 protein disulfide isomerase family A, member 3 -0.0580802
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0535185
S100A6 S100 calcium binding protein A6 -0.0529837
IARS1 isoleucyl-tRNA synthetase 1 -0.0524102
EMP1 epithelial membrane protein 1 -0.0515706
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0502799
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0484595
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0480652
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0454606
TMEM123 transmembrane protein 123 -0.0408019
GNAS GNAS complex locus -0.0403638
EHBP1 EH domain binding protein 1 -0.0399823
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.038876
ANLN anillin, actin binding protein -0.0388512
GARS1 glycyl-tRNA synthetase 1 -0.0383204
ACACA acetyl-CoA carboxylase alpha -0.0374684
RPL35A ribosomal protein L35a -0.0374404
CD2AP CD2-associated protein -0.0372788
RBM39 RNA binding motif protein 39 -0.0367503
DLG1 discs, large homolog 1 (Drosophila) -0.0362008
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0359397
TPT1 tumor protein, translationally-controlled 1 -0.0358368
RAB1A RAB1A, member RAS oncogene family -0.0353948
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.034171
SMC4 structural maintenance of chromosomes 4 -0.0333524
KPNB1 karyopherin (importin) beta 1 -0.0332117
GPX2 glutathione peroxidase 2 -0.0329225
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0324851
RPS21 ribosomal protein S21 -0.0313065
WSB1 WD repeat and SOCS box containing 1 -0.0307873
WARS1 tryptophanyl-tRNA synthetase 1 -0.0304224
THOC2 THO complex 2 -0.0303492
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0303366
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0303067
NF1 neurofibromin 1 -0.030169
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0299004
SLC38A1 solute carrier family 38, member 1 -0.0297836
TFRC transferrin receptor -0.0297564
MSI2 musashi RNA-binding protein 2 -0.0295851
HMGB1 high mobility group box 1 -0.0288676
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.027999
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0276679
DEK DEK proto-oncogene -0.0275246
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0275104
S100A9 S100 calcium binding protein A9 -0.0273781
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0269889
MORF4L2 mortality factor 4 like 2 -0.0266368
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0266179
RPL34 ribosomal protein L34 -0.0263907
RRBP1 ribosome binding protein 1 -0.0262686
KDM3A lysine (K)-specific demethylase 3A -0.0261576
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0256899
CEP95 centrosomal protein 95kDa -0.0256413
UBE3C ubiquitin protein ligase E3C -0.0256404
RPL38 ribosomal protein L38 -0.0254563
ACTG1 actin gamma 1 -0.0249856
RPL8 ribosomal protein L8 -0.0249805
RPS24 ribosomal protein S24 -0.0248649
INSIG1 insulin induced gene 1 -0.0248245
RPS6 ribosomal protein S6 -0.0244918
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0239179
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0237729
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0237321
ANKHD1 ankyrin repeat and KH domain containing 1 -0.023703
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0235179
FAF1 Fas (TNFRSF6) associated factor 1 -0.0235008
TFF2 trefoil factor 2 -0.0234306
MON2 MON2 homolog (S. cerevisiae) -0.0231595
GPHN gephyrin -0.0228733
BIRC6 baculoviral IAP repeat containing 6 -0.0224659
RAB2A RAB2A, member RAS oncogene family -0.0224371
CEMIP cell migration inducing protein, hyaluronan binding -0.0224228
MDK midkine (neurite growth-promoting factor 2) -0.0221375
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0218056
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0218017
GLG1 golgi glycoprotein 1 -0.0217419
EPCAM epithelial cell adhesion molecule -0.0216192
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0213554
FOXK2 forkhead box K2 -0.0213058
STAU1 staufen double-stranded RNA binding protein 1 -0.0211108
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.020965
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0208074
NPC1 Niemann-Pick disease, type C1 -0.0205791
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0204233
FUS FUS RNA binding protein -0.0201483
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0199491
NECTIN2 nectin cell adhesion molecule 2 -0.0193995