Dabrafenib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dabrafenib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.142915
ASPH aspartate beta-hydroxylase 0.109488
LMO7 LIM domain 7 0.10906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0766174
MUC17 mucin 17, cell surface associated 0.0639954
KRT18 keratin 18, type I 0.0593907
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0592495
PSD3 pleckstrin and Sec7 domain containing 3 0.0545118
MACF1 microtubule-actin crosslinking factor 1 0.0542254
EGFR epidermal growth factor receptor 0.0507884
DSPP dentin sialophosphoprotein 0.0483647
EXT1 exostosin glycosyltransferase 1 0.0441219
PLEC plectin 0.0440418
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0423041
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0402812
HSPA8 heat shock 70kDa protein 8 0.038915
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0366637
ERRFI1 ERBB receptor feedback inhibitor 1 0.0361984
SVIL supervillin 0.0349927
AFF1 AF4/FMR2 family, member 1 0.0344346
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0324533
MPRIP myosin phosphatase Rho interacting protein 0.0321068
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0318966
AKAP13 A kinase (PRKA) anchor protein 13 0.031765
LAMC2 laminin, gamma 2 0.0316997
ITPRID2 ITPR interacting domain containing 2 0.030446
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0301049
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.028826
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0287866
MED13 mediator complex subunit 13 0.0280335
ANTXR2 anthrax toxin receptor 2 0.0271818
MYO1E myosin IE 0.0267957
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0266195
ZSWIM6 zinc finger, SWIM-type containing 6 0.0266014
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0263467
MYO5B myosin VB 0.0259695
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025041
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0240541
H1-0 H1.0 linker histone 0.0234989
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0233611
ATXN1 ataxin 1 0.0227053
ANXA1 annexin A1 0.0225001
UNC13B unc-13 homolog B (C. elegans) 0.0221133
FLNB filamin B, beta 0.0215083
ACTN4 actinin, alpha 4 0.0207824
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207219
SLC38A2 solute carrier family 38, member 2 0.0206883
MCL1 myeloid cell leukemia 1 0.0206704
CLCN3 chloride channel, voltage-sensitive 3 0.0204777
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0203871
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0198296
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0194206
EMP1 epithelial membrane protein 1 0.0193594
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0191521
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0191349
RCOR1 REST corepressor 1 0.0186143
FAM107B family with sequence similarity 107, member B 0.0185627
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.018514
WHRN whirlin 0.0183352
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0182242
LAMA4 laminin, alpha 4 0.0182201
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0181123
TGFBR3 transforming growth factor, beta receptor III 0.0180982
IQGAP1 IQ motif containing GTPase activating protein 1 0.0180098
CDCP1 CUB domain containing protein 1 0.0179998
PTPRK protein tyrosine phosphatase, receptor type, K 0.0179178
PDIA4 protein disulfide isomerase family A, member 4 0.0177761
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0176607
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0176358
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0174747
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0172723
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0170714
GLS2 glutaminase 2 (liver, mitochondrial) 0.0170644
MBNL2 muscleblind-like splicing regulator 2 0.0168479
SAMD4A sterile alpha motif domain containing 4A 0.0167334
MARCHF3 membrane associated ring-CH-type finger 3 0.0163794
JARID2 jumonji, AT rich interactive domain 2 0.0163776
MYH9 myosin, heavy chain 9, non-muscle 0.0163225
PARD3B par-3 family cell polarity regulator beta 0.0162477
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0159864
HDLBP high density lipoprotein binding protein 0.015909
GREB1L growth regulation by estrogen in breast cancer-like 0.015707
ARHGAP42 Rho GTPase activating protein 42 0.0153982
NEBL nebulette 0.0153729
KRT8 keratin 8, type II 0.0152856
RORA RAR-related orphan receptor A 0.0152751
APLP2 amyloid beta (A4) precursor-like protein 2 0.0152712
TMSB4X thymosin beta 4, X-linked 0.0149572
SIK3 SIK family kinase 3 0.0149324
SOX9 SRY (sex determining region Y)-box 9 0.0147371
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.0147053
ARHGAP21 Rho GTPase activating protein 21 0.0145315
GOLGB1 golgin B1 0.0142183
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0141913
PDE4D phosphodiesterase 4D, cAMP-specific 0.0141833
MBNL1 muscleblind-like splicing regulator 1 0.0141617
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0139716
KLF5 Kruppel-like factor 5 (intestinal) 0.0139502
BACE2 beta-site APP-cleaving enzyme 2 0.0137536
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.013398

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.29675
NPSR1 neuropeptide S receptor 1 -0.129299
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12137
RPS6 ribosomal protein S6 -0.120938
TPT1 tumor protein, translationally-controlled 1 -0.112483
TMSB10 thymosin beta 10 -0.10036
GPHN gephyrin -0.0782452
RPL35A ribosomal protein L35a -0.0745952
RPLP1 ribosomal protein, large, P1 -0.055839
VCL vinculin -0.0552918
RPS8 ribosomal protein S8 -0.0521914
RPS24 ribosomal protein S24 -0.0516297
RPL34 ribosomal protein L34 -0.0508402
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0489994
RPLP2 ribosomal protein, large, P2 -0.0474356
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0452557
RPL9 ribosomal protein L9 -0.0439785
ACTG1 actin gamma 1 -0.0424953
RPL37A ribosomal protein L37a -0.0417217
GOLGA4 golgin A4 -0.0411837
RPL23 ribosomal protein L23 -0.0406651
TNS4 tensin 4 -0.0397109
RPS29 ribosomal protein S29 -0.0396584
RPS3 ribosomal protein S3 -0.0392034
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0375398
EPCAM epithelial cell adhesion molecule -0.037148
FTH1 ferritin, heavy polypeptide 1 -0.0370564
RPS27A ribosomal protein S27a -0.0367487
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0365317
PNISR PNN-interacting serine/arginine-rich protein -0.0363507
RNF43 ring finger protein 43 -0.0359172
RPS19 ribosomal protein S19 -0.0355981
RPS13 ribosomal protein S13 -0.0350186
FTL ferritin, light polypeptide -0.0347935
RPL31 ribosomal protein L31 -0.0343444
RPS23 ribosomal protein S23 -0.03416
IER3 immediate early response 3 -0.0339455
NALF1 NALCN channel auxiliary factor 1 -0.032519
RPL36 ribosomal protein L36 -0.0319621
RPL7A ribosomal protein L7a -0.0315465
NFIA nuclear factor I/A -0.0312395
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.030674
ALCAM activated leukocyte cell adhesion molecule -0.0305962
RPL5 ribosomal protein L5 -0.0300606
GCC2 GRIP and coiled-coil domain containing 2 -0.0294985
RPL11 ribosomal protein L11 -0.0293891
KPNB1 karyopherin (importin) beta 1 -0.0290982
RPS21 ribosomal protein S21 -0.0287961
RPL26 ribosomal protein L26 -0.0285746
EIF5B eukaryotic translation initiation factor 5B -0.0283613
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.027389
RPL12 ribosomal protein L12 -0.0271582
RPL38 ribosomal protein L38 -0.0269868
RPL8 ribosomal protein L8 -0.0269415
INSIG1 insulin induced gene 1 -0.0266544
PTPRR protein tyrosine phosphatase, receptor type, R -0.0261959
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0258656
LOC102724023 ES1 protein homolog, mitochondrial -0.0258613
RBM25 RNA binding motif protein 25 -0.025635
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0253281
RPS25 ribosomal protein S25 -0.0248923
RPLP0 ribosomal protein, large, P0 -0.0248039
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0242073
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0241218
HMGB1 high mobility group box 1 -0.0238066
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0237055
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0236434
VDAC1 voltage-dependent anion channel 1 -0.0236263
DEK DEK proto-oncogene -0.0235521
TRIM2 tripartite motif containing 2 -0.0234365
AGR2 anterior gradient 2 -0.022873
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0227989
ATP5F1B ATP synthase F1 subunit beta -0.0225855
RPL28 ribosomal protein L28 -0.0224666
GNAS GNAS complex locus -0.0224511
WDR45B WD repeat domain 45B -0.0222441
FDPS farnesyl diphosphate synthase -0.0220037
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0218804
SETD5 SET domain containing 5 -0.0214174
EGR1 early growth response 1 -0.0213055
IARS1 isoleucyl-tRNA synthetase 1 -0.0212617
RPS14 ribosomal protein S14 -0.0212077
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0211821
RPL13A ribosomal protein L13a -0.0211368
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0205929
RPL37 ribosomal protein L37 -0.0204553
RPS11 ribosomal protein S11 -0.0202655
NAP1L1 nucleosome assembly protein 1-like 1 -0.0200376
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0197292
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0194786
DLG1 discs, large homolog 1 (Drosophila) -0.0194456
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0194149
B2M beta-2-microglobulin -0.0190097
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0189149
RPL27A ribosomal protein L27a -0.0186722
TFF3 trefoil factor 3 (intestinal) -0.018669
NCOR1 nuclear receptor corepressor 1 -0.0186185
MLEC malectin -0.0185368
RPS16 ribosomal protein S16 -0.0184776
WSB1 WD repeat and SOCS box containing 1 -0.0182841