| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.191334 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.093509 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0742387 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0643855 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0623897 |
| RPL19 | ribosomal protein L19 | 0.0615206 |
| MT2A | metallothionein 2A | 0.0612983 |
| PYGL | phosphorylase, glycogen, liver | 0.057825 |
| CAPRIN2 | caprin family member 2 | 0.050248 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0404518 |
| KRT18 | keratin 18, type I | 0.0380173 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0377694 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0374753 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0372201 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0371872 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370344 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0364879 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.035709 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0355337 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0340521 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0329475 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0315466 |
| HOMER1 | homer scaffolding protein 1 | 0.030625 |
| RPS12 | ribosomal protein S12 | 0.03057 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0305538 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0302165 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0282066 |
| LOXL2 | lysyl oxidase-like 2 | 0.026799 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0267591 |
| HDLBP | high density lipoprotein binding protein | 0.0265907 |
| TMSB4X | thymosin beta 4, X-linked | 0.0264494 |
| TXNIP | thioredoxin interacting protein | 0.0260578 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0259315 |
| GOLGB1 | golgin B1 | 0.0254751 |
| MCL1 | myeloid cell leukemia 1 | 0.025386 |
| LDHA | lactate dehydrogenase A | 0.0247451 |
| NPAS2 | neuronal PAS domain protein 2 | 0.024721 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0244356 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0240123 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0239837 |
| EMP1 | epithelial membrane protein 1 | 0.0239663 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0235493 |
| PLEC | plectin | 0.0230312 |
| JUN | jun proto-oncogene | 0.0229179 |
| CALR | calreticulin | 0.0219977 |
| RGS4 | regulator of G-protein signaling 4 | 0.0217672 |
| RPL12 | ribosomal protein L12 | 0.0217515 |
| PRELID2 | PRELI domain containing 2 | 0.0209381 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.020671 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.020645 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0204022 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0201262 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0201027 |
| CANX | calnexin | 0.0198854 |
| RPS4X | ribosomal protein S4, X-linked | 0.0195451 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0195073 |
| PYGB | phosphorylase, glycogen; brain | 0.0192727 |
| INTS6 | integrator complex subunit 6 | 0.0192713 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0190846 |
| PODXL | podocalyxin-like | 0.0189779 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0185895 |
| ARRDC3 | arrestin domain containing 3 | 0.0184404 |
| NEK10 | NIMA-related kinase 10 | 0.018073 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0176252 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0176202 |
| ANGPTL4 | angiopoietin-like 4 | 0.0175456 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0175336 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0175205 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.017451 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0172034 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0171747 |
| TPM3 | tropomyosin 3 | 0.0171069 |
| RPL4 | ribosomal protein L4 | 0.0169156 |
| RPS18 | ribosomal protein S18 | 0.0168771 |
| RCOR1 | REST corepressor 1 | 0.0168686 |
| SQSTM1 | sequestosome 1 | 0.0168578 |
| SPAG9 | sperm associated antigen 9 | 0.0167361 |
| HMGA1 | high mobility group AT-hook 1 | 0.0167129 |
| RPS17 | ribosomal protein S17 | 0.0166966 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0166933 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0166852 |
| RPS8 | ribosomal protein S8 | 0.0165973 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0165747 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0164863 |
| SMAD3 | SMAD family member 3 | 0.0164407 |
| RPL26 | ribosomal protein L26 | 0.0163983 |
| RPL7 | ribosomal protein L7 | 0.0162158 |
| RPL3 | ribosomal protein L3 | 0.0159232 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0159053 |
| SGMS2 | sphingomyelin synthase 2 | 0.0159029 |
| RPS27 | ribosomal protein S27 | 0.0157855 |
| RUNX1 | runt-related transcription factor 1 | 0.0156043 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0154348 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0152424 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0152106 |
| CEP250 | centrosomal protein 250kDa | 0.0150739 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0149336 |
| ACTN1 | actinin, alpha 1 | 0.0148772 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0148362 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0147537 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131341 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0995189 |
| PTMA | prothymosin, alpha | -0.099116 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.094342 |
| POTEF | POTE ankyrin domain family, member F | -0.0783161 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0713933 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0589574 |
| TMSB10 | thymosin beta 10 | -0.0587333 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0573731 |
| TP63 | tumor protein p63 | -0.0535117 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0468076 |
| RPL35A | ribosomal protein L35a | -0.0425757 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0410969 |
| EFNA5 | ephrin-A5 | -0.0380597 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0379252 |
| EPHA4 | EPH receptor A4 | -0.0368914 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0354602 |
| RBM25 | RNA binding motif protein 25 | -0.0330094 |
| ZNF292 | zinc finger protein 292 | -0.0328597 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0327716 |
| TNS3 | tensin 3 | -0.0323638 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0317052 |
| PTK2 | protein tyrosine kinase 2 | -0.0314241 |
| WDR45B | WD repeat domain 45B | -0.0309399 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0291218 |
| RTN4 | reticulon 4 | -0.0290861 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0290095 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0283334 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0277943 |
| THOC2 | THO complex 2 | -0.0277036 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0276167 |
| SRGN | serglycin | -0.0274911 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0272013 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0269742 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0269477 |
| RPS6 | ribosomal protein S6 | -0.0268231 |
| RBM39 | RNA binding motif protein 39 | -0.0262617 |
| FTL | ferritin, light polypeptide | -0.0260525 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0259148 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0254723 |
| CENPF | centromere protein F, 350/400kDa | -0.0251314 |
| KPNB1 | karyopherin (importin) beta 1 | -0.025068 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0249535 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0248554 |
| CD44 | CD44 molecule (Indian blood group) | -0.0247814 |
| RAI1 | retinoic acid induced 1 | -0.0245344 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0244121 |
| ACTG1 | actin gamma 1 | -0.0227223 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0226321 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0225159 |
| FUS | FUS RNA binding protein | -0.0224675 |
| GNAS | GNAS complex locus | -0.0222549 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0222384 |
| SRPK2 | SRSF protein kinase 2 | -0.022126 |
| XPO1 | exportin 1 | -0.0219488 |
| COL5A2 | collagen, type V, alpha 2 | -0.0217868 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0215953 |
| HLA-B | major histocompatibility complex, class I, B | -0.0213378 |
| TMEM123 | transmembrane protein 123 | -0.0209738 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0209446 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0207358 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0204337 |
| ZNF148 | zinc finger protein 148 | -0.0202122 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0201968 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.020167 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0201093 |
| RIGI | RNA sensor RIG-I | -0.0201071 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0199696 |
| GLG1 | golgi glycoprotein 1 | -0.0199567 |
| GOLGA4 | golgin A4 | -0.0197726 |
| RPS21 | ribosomal protein S21 | -0.0197464 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0195471 |
| EHBP1 | EH domain binding protein 1 | -0.0194858 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0193021 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0190329 |
| TOP1 | topoisomerase (DNA) I | -0.0188996 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -0.0188836 |
| CCNL1 | cyclin L1 | -0.0187178 |
| S100A9 | S100 calcium binding protein A9 | -0.0187022 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0186213 |
| WASF2 | WAS protein family, member 2 | -0.0185949 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0185861 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0184257 |
| SEPTIN7 | septin 7 | -0.0184184 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0184029 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0183577 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0183394 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0182758 |
| MAP4 | microtubule-associated protein 4 | -0.0182475 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0182182 |
| UBE3C | ubiquitin protein ligase E3C | -0.0180311 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0179679 |
| MATR3 | matrin 3 | -0.017851 |
| EGR1 | early growth response 1 | -0.0177735 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0176625 |
| SBF2 | SET binding factor 2 | -0.0176261 |
| FBXO11 | F-box protein 11 | -0.0174541 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0173084 |
| NF1 | neurofibromin 1 | -0.0172889 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0172879 |
