| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.249892 |
| MCL1 | myeloid cell leukemia 1 | 0.169397 |
| SLTM | SAFB-like, transcription modulator | 0.114356 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.113533 |
| ENO1 | enolase 1, (alpha) | 0.108412 |
| MT2A | metallothionein 2A | 0.106046 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.10169 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0986287 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0969754 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0944435 |
| GRAMD1B | GRAM domain containing 1B | 0.0928693 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0892999 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0883532 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0880224 |
| KRT18 | keratin 18, type I | 0.0872366 |
| SMAD3 | SMAD family member 3 | 0.0858895 |
| RPL19 | ribosomal protein L19 | 0.0834959 |
| STC1 | stanniocalcin 1 | 0.0830742 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0819837 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0789028 |
| RPS3 | ribosomal protein S3 | 0.0740881 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0732226 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0728273 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0716689 |
| PYGL | phosphorylase, glycogen, liver | 0.0692409 |
| RPL7 | ribosomal protein L7 | 0.068502 |
| LDHA | lactate dehydrogenase A | 0.0676341 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0644205 |
| PCBP2 | poly(rC) binding protein 2 | 0.0622665 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0611822 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0609644 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0608934 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0604492 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0600523 |
| CES1 | carboxylesterase 1 | 0.0596982 |
| PLEC | plectin | 0.0584674 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.054815 |
| RNF213 | ring finger protein 213 | 0.0548092 |
| ARRDC3 | arrestin domain containing 3 | 0.0547958 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0534912 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0518909 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0501275 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.050016 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0500138 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0495956 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0487472 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0484959 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0482853 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0481218 |
| RPS12 | ribosomal protein S12 | 0.0476455 |
| TOP1 | topoisomerase (DNA) I | 0.0473219 |
| LAMB3 | laminin, beta 3 | 0.0472043 |
| MSN | moesin | 0.0466885 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0460272 |
| PKM | pyruvate kinase, muscle | 0.0455595 |
| MYOF | myoferlin | 0.0455502 |
| DSPP | dentin sialophosphoprotein | 0.0455145 |
| FAM13A | family with sequence similarity 13, member A | 0.0449493 |
| ANXA5 | annexin A5 | 0.0448815 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0447684 |
| HYOU1 | hypoxia up-regulated 1 | 0.0439471 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0432772 |
| TPM3 | tropomyosin 3 | 0.0429521 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0425522 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0425431 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0424429 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0423271 |
| TPI1 | triosephosphate isomerase 1 | 0.0419007 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0417617 |
| CDCP1 | CUB domain containing protein 1 | 0.0412829 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0410924 |
| GOLGB1 | golgin B1 | 0.0403248 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0393163 |
| RPS8 | ribosomal protein S8 | 0.0391041 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0378943 |
| MAGEA4 | melanoma antigen family A4 | 0.0377767 |
| SON | SON DNA binding protein | 0.0373067 |
| CUL4A | cullin 4A | 0.0364499 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0362415 |
| ATP11A | ATPase, class VI, type 11A | 0.0354403 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0353323 |
| RUNX1 | runt-related transcription factor 1 | 0.0353222 |
| RPS17 | ribosomal protein S17 | 0.0352728 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0351369 |
| RPS27 | ribosomal protein S27 | 0.0350945 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0346723 |
| RPS4X | ribosomal protein S4, X-linked | 0.0341702 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0341099 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0335214 |
| BMP6 | bone morphogenetic protein 6 | 0.033282 |
| RPL37A | ribosomal protein L37a | 0.0331027 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.032956 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0323711 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0317802 |
| RPL3 | ribosomal protein L3 | 0.0316027 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0315485 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0315388 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0314745 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0313976 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0313936 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.151151 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.110556 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.102313 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0897021 |
| ASPH | aspartate beta-hydroxylase | -0.0869152 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0688264 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0656285 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0611018 |
| H1-0 | H1.0 linker histone | -0.058047 |
| TMSB10 | thymosin beta 10 | -0.0554821 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0546478 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0498413 |
| TXNRD1 | thioredoxin reductase 1 | -0.0498218 |
| ACTG1 | actin gamma 1 | -0.0497921 |
| AHNAK | AHNAK nucleoprotein | -0.0483687 |
| EFNA5 | ephrin-A5 | -0.0470769 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0453518 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0452031 |
| EGR1 | early growth response 1 | -0.0391845 |
| VCL | vinculin | -0.0389183 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0379304 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0350415 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0335355 |
| TNS3 | tensin 3 | -0.0332573 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.032528 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0317528 |
| INTS6 | integrator complex subunit 6 | -0.030732 |
| KRT7 | keratin 7, type II | -0.0306034 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0301594 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.029946 |
| GM2A | GM2 ganglioside activator | -0.0297163 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0294974 |
| OSMR | oncostatin M receptor | -0.0294213 |
| MGAT4C | MGAT4 family, member C | -0.0279343 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0279161 |
| AGR2 | anterior gradient 2 | -0.027334 |
| FBXO11 | F-box protein 11 | -0.0271544 |
| PDE8A | phosphodiesterase 8A | -0.0267581 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0266767 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0260236 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0258591 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0257822 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0257526 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0253559 |
| CUX1 | cut-like homeobox 1 | -0.0253435 |
| GNAS | GNAS complex locus | -0.0251144 |
| WDR45B | WD repeat domain 45B | -0.0250227 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0246566 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0244236 |
| HLA-B | major histocompatibility complex, class I, B | -0.0240073 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0237612 |
| PCED1B | PC-esterase domain containing 1B | -0.0237453 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0236858 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0234947 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0232006 |
| NABP1 | nucleic acid binding protein 1 | -0.0231141 |
| PRKCA | protein kinase C, alpha | -0.0231036 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0229744 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0229129 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0228365 |
| NF1 | neurofibromin 1 | -0.0224856 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0224052 |
| LMO7 | LIM domain 7 | -0.0223348 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0223012 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0222523 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0215745 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0215319 |
| IER3 | immediate early response 3 | -0.0214754 |
| SDC4 | syndecan 4 | -0.0212671 |
| SCEL | sciellin | -0.0211704 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0211113 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.020942 |
| CP | ceruloplasmin (ferroxidase) | -0.020814 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0207593 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0206766 |
| FUS | FUS RNA binding protein | -0.0203814 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0203454 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0197151 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0196836 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0196495 |
| CCND1 | cyclin D1 | -0.0196148 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.019459 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0192756 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0191569 |
| SMIM14 | small integral membrane protein 14 | -0.019155 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0188756 |
| FBXO34 | F-box protein 34 | -0.0187634 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0186373 |
| RIN2 | Ras and Rab interactor 2 | -0.0185464 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0184416 |
| RPS24 | ribosomal protein S24 | -0.018332 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0175865 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0173584 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0170198 |
| TMEM263 | transmembrane protein 263 | -0.0167907 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0166954 |
| ETV6 | ets variant 6 | -0.0164979 |
| TRIM56 | tripartite motif containing 56 | -0.016451 |
| MCU | mitochondrial calcium uniporter | -0.0159968 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0158027 |
