Dabrafenib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dabrafenib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.297168
AKAP12 A kinase (PRKA) anchor protein 12 0.202113
LOXL2 lysyl oxidase-like 2 0.0918842
IGFBP3 insulin-like growth factor binding protein 3 0.0863486
TIMP1 TIMP metallopeptidase inhibitor 1 0.0817763
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.081687
FN1 fibronectin 1 0.0696299
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.060403
GRB10 growth factor receptor-bound protein 10 0.0584648
ANGPTL4 angiopoietin-like 4 0.0537215
NDRG1 N-myc downstream regulated 1 0.0535113
STC1 stanniocalcin 1 0.051407
RPL19 ribosomal protein L19 0.050122
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0485015
SOD2 superoxide dismutase 2, mitochondrial 0.0469567
EXT1 exostosin glycosyltransferase 1 0.0451342
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0450618
PDGFA platelet-derived growth factor alpha polypeptide 0.0427507
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0417707
RPS12 ribosomal protein S12 0.0390584
LDHA lactate dehydrogenase A 0.0390388
SEPTIN9 septin 9 0.0383176
B2M beta-2-microglobulin 0.0374651
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0372404
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0367549
MYO10 myosin X 0.0362648
CDCP1 CUB domain containing protein 1 0.0359898
ECE1 endothelin converting enzyme 1 0.0358907
TMSB4X thymosin beta 4, X-linked 0.035801
HIPK2 homeodomain interacting protein kinase 2 0.0355961
PLIN2 perilipin 2 0.0353529
MACF1 microtubule-actin crosslinking factor 1 0.0353358
PYGL phosphorylase, glycogen, liver 0.035291
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0352356
SMAD3 SMAD family member 3 0.0351718
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0345291
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0345002
MYH9 myosin, heavy chain 9, non-muscle 0.0344956
TFPI2 tissue factor pathway inhibitor 2 0.0336189
HMGA1 high mobility group AT-hook 1 0.033121
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.033121
RPS8 ribosomal protein S8 0.0327547
APLP2 amyloid beta (A4) precursor-like protein 2 0.0326756
EIF1 eukaryotic translation initiation factor 1 0.032264
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0310783
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0306128
AADAC arylacetamide deacetylase 0.0297845
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0297682
LOC102724023 ES1 protein homolog, mitochondrial 0.0297259
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0290403
BHLHE40 basic helix-loop-helix family, member e40 0.0288291
CD44 CD44 molecule (Indian blood group) 0.0288258
RPL31 ribosomal protein L31 0.0285881
NAV2 neuron navigator 2 0.0280304
PRSS23 protease, serine, 23 0.0279039
RPL37A ribosomal protein L37a 0.0272224
RPL11 ribosomal protein L11 0.0270435
CAPN2 calpain 2, (m/II) large subunit 0.0264913
ALCAM activated leukocyte cell adhesion molecule 0.026354
RPS17 ribosomal protein S17 0.0263002
ZSWIM6 zinc finger, SWIM-type containing 6 0.0260826
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0252051
RNF213 ring finger protein 213 0.0249299
MCL1 myeloid cell leukemia 1 0.02487
RPS27 ribosomal protein S27 0.0246802
RPL7 ribosomal protein L7 0.0246501
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0245151
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0243619
ARL4C ADP-ribosylation factor-like 4C 0.0243357
PLEC plectin 0.0241096
IRAK2 interleukin-1 receptor-associated kinase 2 0.0240256
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0234422
SFTPA2 surfactant protein A2 0.0233163
EEF1G eukaryotic translation elongation factor 1 gamma 0.0230351
SQSTM1 sequestosome 1 0.0229981
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0228515
ANTXR2 anthrax toxin receptor 2 0.0227507
FTH1 ferritin, heavy polypeptide 1 0.02274
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0225023
NAP1L1 nucleosome assembly protein 1-like 1 0.0224246
KRT19 keratin 19, type I 0.0216301
OPTN optineurin 0.0215826
ENO1 enolase 1, (alpha) 0.0214927
ANKRD28 ankyrin repeat domain 28 0.0214795
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0214674
FAM107B family with sequence similarity 107, member B 0.0213726
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213559
RAI14 retinoic acid induced 14 0.0212345
TGM2 transglutaminase 2 0.0211588
S100A6 S100 calcium binding protein A6 0.0209228
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0208803
MYADM myeloid-associated differentiation marker 0.0204942
BACE2 beta-site APP-cleaving enzyme 2 0.0203616
ANXA2 annexin A2 0.0203424
S100A10 S100 calcium binding protein A10 0.0203347
VEGFA vascular endothelial growth factor A 0.0202995
CA12 carbonic anhydrase XII 0.020237
RPS3 ribosomal protein S3 0.0202182
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0202099
ICAM1 intercellular adhesion molecule 1 0.0200786

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.17869
PDE4D phosphodiesterase 4D, cAMP-specific -0.132451
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0981183
RBM39 RNA binding motif protein 39 -0.0941808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0798362
SDK1 sidekick cell adhesion molecule 1 -0.0612967
ELL2 elongation factor, RNA polymerase II, 2 -0.0609905
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0605527
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.06045
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0553268
FNDC3B fibronectin type III domain containing 3B -0.0526067
NCOA7 nuclear receptor coactivator 7 -0.0491196
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0481476
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0465718
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0455466
OSMR oncostatin M receptor -0.0439173
UBC ubiquitin C -0.0437504
OGA O-GlcNAcase -0.0436962
VMP1 vacuole membrane protein 1 -0.0399975
KDM2A lysine (K)-specific demethylase 2A -0.0395279
PRELID2 PRELI domain containing 2 -0.0390791
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0376985
NPC1 Niemann-Pick disease, type C1 -0.0374357
USP34 ubiquitin specific peptidase 34 -0.0363362
GPC6 glypican 6 -0.035835
GLCCI1 glucocorticoid induced 1 -0.0348538
WSB1 WD repeat and SOCS box containing 1 -0.0346335
KDM3A lysine (K)-specific demethylase 3A -0.0327259
KMT2C lysine (K)-specific methyltransferase 2C -0.0325735
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0324969
ZNF292 zinc finger protein 292 -0.0303616
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0302601
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.030121
ETV6 ets variant 6 -0.0300644
PTMA prothymosin, alpha -0.0293978
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0287397
NRG1 neuregulin 1 -0.0286445
WDR45B WD repeat domain 45B -0.0284956
PCBP2 poly(rC) binding protein 2 -0.0279747
IER3 immediate early response 3 -0.0275999
ZMYND8 zinc finger, MYND-type containing 8 -0.0272452
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0271344
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0271172
ITCH itchy E3 ubiquitin protein ligase -0.026942
TAS2R14 taste receptor, type 2, member 14 -0.0266129
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0261435
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0259609
NF1 neurofibromin 1 -0.0257589
ZFAND3 zinc finger, AN1-type domain 3 -0.0254575
SPAG9 sperm associated antigen 9 -0.0249927
KCTD16 potassium channel tetramerization domain containing 16 -0.0249574
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0243312
NEK7 NIMA-related kinase 7 -0.0239891
BASP1 brain abundant, membrane attached signal protein 1 -0.0238694
PDIA3 protein disulfide isomerase family A, member 3 -0.0238058
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0237678
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0235869
MBD5 methyl-CpG binding domain protein 5 -0.0230252
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0229268
ZBTB20 zinc finger and BTB domain containing 20 -0.0227623
ATP13A3 ATPase type 13A3 -0.0226806
MARCHF6 membrane associated ring-CH-type finger 6 -0.0223375
STRN3 striatin, calmodulin binding protein 3 -0.0222196
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.022193
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0221738
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0218353
RAB1A RAB1A, member RAS oncogene family -0.021625
JMJD1C jumonji domain containing 1C -0.0214711
FOXO3 forkhead box O3 -0.021157
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0209994
PHIP pleckstrin homology domain interacting protein -0.0205647
AHNAK AHNAK nucleoprotein -0.0205518
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0204079
OXSR1 oxidative stress responsive 1 -0.0201935
ZNF804A zinc finger protein 804A -0.0199197
METTL15 methyltransferase like 15 -0.0198374
TMEM263 transmembrane protein 263 -0.0198311
MON2 MON2 homolog (S. cerevisiae) -0.0198098
PID1 phosphotyrosine interaction domain containing 1 -0.0196514
NBAS neuroblastoma amplified sequence -0.0195941
UGCG UDP-glucose ceramide glucosyltransferase -0.0195304
LIMCH1 LIM and calponin homology domains 1 -0.0195109
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0193986
COG5 component of oligomeric golgi complex 5 -0.0193395
DPYD dihydropyrimidine dehydrogenase -0.0193292
PHF21A PHD finger protein 21A -0.0190296
MORF4L2 mortality factor 4 like 2 -0.0189796
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0188422
PARD3 par-3 family cell polarity regulator -0.0188112
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0187054
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0186529
LMAN1 lectin, mannose-binding, 1 -0.0186434
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0186068
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0185694
ARF4 ADP-ribosylation factor 4 -0.0185464
DLG1 discs, large homolog 1 (Drosophila) -0.0183527
TM4SF1 transmembrane 4 L six family member 1 -0.0182908
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0182379
SRP54 signal recognition particle 54kDa -0.0180364
HELZ helicase with zinc finger -0.0180232