| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.239843 |
| MT2A | metallothionein 2A | 0.228717 |
| MCL1 | myeloid cell leukemia 1 | 0.222994 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.211364 |
| GRAMD1B | GRAM domain containing 1B | 0.141804 |
| RPL19 | ribosomal protein L19 | 0.135169 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.113696 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.104869 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.104759 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.103981 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0910162 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0892501 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0718341 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0714767 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0701666 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0699661 |
| PYGL | phosphorylase, glycogen, liver | 0.0698904 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0691473 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0689789 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0686251 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0675056 |
| RPL7 | ribosomal protein L7 | 0.0638938 |
| FAM107B | family with sequence similarity 107, member B | 0.0631684 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.061869 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0598743 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0595303 |
| RPS12 | ribosomal protein S12 | 0.0585382 |
| STC1 | stanniocalcin 1 | 0.0522958 |
| LAMC2 | laminin, gamma 2 | 0.0518647 |
| RPLP1 | ribosomal protein, large, P1 | 0.0509532 |
| TPM3 | tropomyosin 3 | 0.0508981 |
| KIF5B | kinesin family member 5B | 0.0506076 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0497167 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0490289 |
| FLNB | filamin B, beta | 0.0487019 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0479623 |
| RPS27 | ribosomal protein S27 | 0.0467473 |
| PLEC | plectin | 0.0465613 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0445581 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0434825 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.043055 |
| RPS17 | ribosomal protein S17 | 0.0428343 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0421698 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0414144 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0413607 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0410807 |
| RPL23 | ribosomal protein L23 | 0.0407831 |
| HLA-E | major histocompatibility complex, class I, E | 0.0404015 |
| RPL37A | ribosomal protein L37a | 0.0402649 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0379778 |
| CALR | calreticulin | 0.0376723 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0376435 |
| NRG1 | neuregulin 1 | 0.0371153 |
| RPL3 | ribosomal protein L3 | 0.0360979 |
| RPS8 | ribosomal protein S8 | 0.0359927 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0352605 |
| BMP6 | bone morphogenetic protein 6 | 0.0352313 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0348337 |
| RPS25 | ribosomal protein S25 | 0.0344209 |
| STC2 | stanniocalcin 2 | 0.0339468 |
| FLNA | filamin A, alpha | 0.0336155 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0333531 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0328414 |
| UPP1 | uridine phosphorylase 1 | 0.0324646 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0324328 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.032103 |
| ASPH | aspartate beta-hydroxylase | 0.0317274 |
| RPL4 | ribosomal protein L4 | 0.0316924 |
| SFTPA2 | surfactant protein A2 | 0.0315585 |
| APP | amyloid beta (A4) precursor protein | 0.0314617 |
| HLA-A | major histocompatibility complex, class I, A | 0.0310769 |
| HYOU1 | hypoxia up-regulated 1 | 0.0304273 |
| GOLGB1 | golgin B1 | 0.0299834 |
| RPL31 | ribosomal protein L31 | 0.0297818 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0297512 |
| ANGPTL4 | angiopoietin-like 4 | 0.0294373 |
| RPL26 | ribosomal protein L26 | 0.0290433 |
| RPS20 | ribosomal protein S20 | 0.0287238 |
| RPL11 | ribosomal protein L11 | 0.0285801 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0284568 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0281867 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.028097 |
| ATF4 | activating transcription factor 4 | 0.027556 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0274354 |
| TLN1 | talin 1 | 0.0273942 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0273003 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0272327 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0268815 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.026396 |
| RPS29 | ribosomal protein S29 | 0.0261871 |
| KRT18 | keratin 18, type I | 0.0260667 |
| RPS3 | ribosomal protein S3 | 0.0260251 |
| RPL37 | ribosomal protein L37 | 0.0258777 |
| WWOX | WW domain containing oxidoreductase | 0.0252813 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0249326 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0249064 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0249002 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0248689 |
| CDCP1 | CUB domain containing protein 1 | 0.02448 |
| NUMB | numb homolog (Drosophila) | 0.0244354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.17433 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.108696 |
| POTEF | POTE ankyrin domain family, member F | -0.0927662 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0879192 |
| NEGR1 | neuronal growth regulator 1 | -0.084396 |
| IGF2 | insulin-like growth factor 2 | -0.0741714 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0726899 |
| BICC1 | BicC family RNA binding protein 1 | -0.0700444 |
| ERBIN | erbb2 interacting protein | -0.0595591 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0581442 |
| FGB | fibrinogen beta chain | -0.0577739 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0551358 |
| ACTG1 | actin gamma 1 | -0.0538033 |
| EFNA5 | ephrin-A5 | -0.0532464 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0491644 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0457002 |
| PFN1 | profilin 1 | -0.043406 |
| RASAL2 | RAS protein activator like 2 | -0.0425386 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0424283 |
| DST | dystonin | -0.0422573 |
| PLS3 | plastin 3 | -0.0421513 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0409773 |
| PRR16 | proline rich 16 | -0.0405073 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0404546 |
| AHR | aryl hydrocarbon receptor | -0.0404106 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0403738 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0403625 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.040253 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0389346 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0371057 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0365641 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.035554 |
| HDAC9 | histone deacetylase 9 | -0.0355286 |
| RBM25 | RNA binding motif protein 25 | -0.035488 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0350484 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0349653 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0343985 |
| WDR43 | WD repeat domain 43 | -0.0341666 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0339619 |
| TPM1 | tropomyosin 1 (alpha) | -0.0333833 |
| GLIS3 | GLIS family zinc finger 3 | -0.0330345 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0325789 |
| NTN4 | netrin 4 | -0.031996 |
| DENND4A | DENN/MADD domain containing 4A | -0.0318723 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0318215 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0316427 |
| EHBP1 | EH domain binding protein 1 | -0.0314123 |
| CCNL1 | cyclin L1 | -0.0313131 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0312416 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0311837 |
| RHOA | ras homolog family member A | -0.0308871 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0301626 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0301251 |
| VCL | vinculin | -0.0297916 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.02904 |
| ECT2 | epithelial cell transforming 2 | -0.028627 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0283271 |
| CHN1 | chimerin 1 | -0.0283053 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0280026 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0277803 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0277684 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0275504 |
| MYOF | myoferlin | -0.0270925 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0269277 |
| NOP58 | NOP58 ribonucleoprotein | -0.0268401 |
| NEBL | nebulette | -0.0266721 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0265483 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0262796 |
| FTL | ferritin, light polypeptide | -0.0259848 |
| THBS1 | thrombospondin 1 | -0.0259828 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0259139 |
| UTRN | utrophin | -0.0257887 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0255441 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0252715 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.025026 |
| SLC35F3 | solute carrier family 35, member F3 | -0.024592 |
| SMAD2 | SMAD family member 2 | -0.0240661 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0239475 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0238057 |
| ZNF644 | zinc finger protein 644 | -0.0236551 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0233107 |
| CALD1 | caldesmon 1 | -0.0232464 |
| ZNF207 | zinc finger protein 207 | -0.0231822 |
| PDE8A | phosphodiesterase 8A | -0.0231448 |
| TGFB2 | transforming growth factor, beta 2 | -0.0229265 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0227369 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0226336 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0224897 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0223761 |
| TNS3 | tensin 3 | -0.0222986 |
| LMNA | lamin A/C | -0.0222334 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0221626 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0220879 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0220671 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0219658 |
| MT1X | metallothionein 1X | -0.0219475 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0218419 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0216865 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0212481 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0211158 |
