| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.191811 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.141233 |
| LMO7 | LIM domain 7 | 0.135802 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.109395 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.103128 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.102308 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.099325 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0986829 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0973271 |
| MYO1E | myosin IE | 0.0951486 |
| KYNU | kynureninase | 0.0907873 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0902845 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0862026 |
| EFNA5 | ephrin-A5 | 0.0777118 |
| EZR | ezrin | 0.0747917 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0720528 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0703287 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.070142 |
| LAMC2 | laminin, gamma 2 | 0.065711 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0651058 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0583167 |
| LAMB3 | laminin, beta 3 | 0.0557769 |
| MCL1 | myeloid cell leukemia 1 | 0.0542136 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0533991 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0527476 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0523778 |
| VIM | vimentin | 0.0516983 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0503465 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0496723 |
| CDH13 | cadherin 13 | 0.0494109 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0493392 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0493318 |
| CUX1 | cut-like homeobox 1 | 0.0478566 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0477993 |
| ABHD17C | abhydrolase domain containing 17C | 0.0477234 |
| CMIP | c-Maf inducing protein | 0.047253 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0468556 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0450198 |
| ATOSA | atos homolog A | 0.0449972 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0448922 |
| KRT17 | keratin 17, type I | 0.0442662 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0420332 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0420211 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0407956 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.038609 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0382813 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0376893 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0376162 |
| ATXN1 | ataxin 1 | 0.0374452 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0373377 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0373348 |
| RCOR1 | REST corepressor 1 | 0.0369964 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.0352602 |
| STC1 | stanniocalcin 1 | 0.0352053 |
| DSPP | dentin sialophosphoprotein | 0.034858 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0345412 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0342109 |
| SMAD3 | SMAD family member 3 | 0.0337975 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0335473 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0335281 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0331825 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0329557 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0328554 |
| PARD3 | par-3 family cell polarity regulator | 0.032393 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0323796 |
| TUFT1 | tuftelin 1 | 0.0321739 |
| ANXA2 | annexin A2 | 0.0310945 |
| LSAMP | limbic system-associated membrane protein | 0.0310709 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0308267 |
| PTMA | prothymosin, alpha | 0.0307118 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0302454 |
| MYO6 | myosin VI | 0.028669 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0286673 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0284784 |
| RPLP1 | ribosomal protein, large, P1 | 0.0284142 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0279603 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0275558 |
| FN1 | fibronectin 1 | 0.0270769 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0269596 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.026909 |
| ERBIN | erbb2 interacting protein | 0.0266072 |
| CUL3 | cullin 3 | 0.0264229 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0262567 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0261278 |
| RPL23 | ribosomal protein L23 | 0.0260752 |
| RREB1 | ras responsive element binding protein 1 | 0.0259192 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0258759 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0258005 |
| FBXO11 | F-box protein 11 | 0.0255729 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0253844 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0252878 |
| SVIL | supervillin | 0.0252473 |
| TPR | translocated promoter region, nuclear basket protein | 0.0251162 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0250408 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0246069 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0246 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0245197 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0245027 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0241584 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0239359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3A | fibronectin type III domain containing 3A | -0.0665027 |
| NAV2 | neuron navigator 2 | -0.0560551 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0557844 |
| RBM39 | RNA binding motif protein 39 | -0.055304 |
| GOLGA4 | golgin A4 | -0.0478288 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0466822 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.046144 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0453578 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0436318 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0418323 |
| MYOF | myoferlin | -0.0406537 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0405259 |
| RTN4 | reticulon 4 | -0.0404013 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0396021 |
| NBEA | neurobeachin | -0.0385286 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0378196 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0375068 |
| CFDP1 | craniofacial development protein 1 | -0.0366191 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0363794 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0355452 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0355006 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0354573 |
| CDC27 | cell division cycle 27 | -0.0347805 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0343299 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0340373 |
| RAB1A | RAB1A, member RAS oncogene family | -0.03362 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0335075 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0334442 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0332365 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.032918 |
| STK24 | serine/threonine kinase 24 | -0.0326552 |
| TMEM263 | transmembrane protein 263 | -0.0325797 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0325634 |
| B2M | beta-2-microglobulin | -0.0322735 |
| CDC73 | cell division cycle 73 | -0.0322403 |
| LDHA | lactate dehydrogenase A | -0.0316364 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0314362 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0306553 |
| RASA2 | RAS p21 protein activator 2 | -0.0306407 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0305292 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0305015 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0302565 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.029874 |
| OGA | O-GlcNAcase | -0.0298412 |
| MACC1 | metastasis associated in colon cancer 1 | -0.029378 |
| EWSR1 | EWS RNA-binding protein 1 | -0.029245 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0292157 |
| MTSS1 | metastasis suppressor 1 | -0.0289138 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.028901 |
| MORF4L1 | mortality factor 4 like 1 | -0.0284557 |
| PTGES2 | prostaglandin E synthase 2 | -0.0281116 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.0277226 |
| KIAA1217 | KIAA1217 | -0.0276147 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0275161 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0275007 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0274697 |
| CDK12 | cyclin-dependent kinase 12 | -0.0274017 |
| RBM25 | RNA binding motif protein 25 | -0.0272941 |
| FOXJ3 | forkhead box J3 | -0.0271042 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.027036 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0264233 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0262597 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.0262388 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0259796 |
| UBN2 | ubinuclein 2 | -0.0259549 |
| XPO1 | exportin 1 | -0.0258269 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0257748 |
| SUCO | SUN domain containing ossification factor | -0.025625 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0256052 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0255436 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0253373 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0253274 |
| SEC24D | SEC24 family member D | -0.0252862 |
| JMJD1C | jumonji domain containing 1C | -0.0252231 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0251452 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0249388 |
| MALT1 | MALT1 paracaspase | -0.0249384 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0248457 |
| H1-0 | H1.0 linker histone | -0.0247629 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0247215 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0246861 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0245076 |
| ATXN2 | ataxin 2 | -0.0245046 |
| CENPF | centromere protein F, 350/400kDa | -0.0244105 |
| NKTR | natural killer cell triggering receptor | -0.024408 |
| HEBP2 | heme binding protein 2 | -0.0243951 |
| ATP13A3 | ATPase type 13A3 | -0.0243914 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0242829 |
| GDI2 | GDP dissociation inhibitor 2 | -0.024235 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0241023 |
| PRSS23 | protease, serine, 23 | -0.0240957 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0240594 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.0240304 |
| WDR45B | WD repeat domain 45B | -0.023944 |
| ARF4 | ADP-ribosylation factor 4 | -0.0237516 |
| SPAG9 | sperm associated antigen 9 | -0.0237377 |
| NUP58 | nucleoporin 58 | -0.0233052 |
| HMBOX1 | homeobox containing 1 | -0.0232613 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0232317 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0232076 |
