| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.481865 |
| MCL1 | myeloid cell leukemia 1 | 0.221279 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.166714 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.100585 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.09891 |
| VIM | vimentin | 0.0931633 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.086008 |
| PYGL | phosphorylase, glycogen, liver | 0.0783411 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0729679 |
| GRAMD1B | GRAM domain containing 1B | 0.0718579 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0698748 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0680818 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.066796 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0648454 |
| ATP11A | ATPase, class VI, type 11A | 0.0638232 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0630966 |
| XPOT | exportin, tRNA | 0.0594176 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0588923 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0584669 |
| LOXL2 | lysyl oxidase-like 2 | 0.0566169 |
| RPS27 | ribosomal protein S27 | 0.0546368 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0538765 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0536314 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0514253 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0485967 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0466253 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0465661 |
| KRT18 | keratin 18, type I | 0.0465605 |
| STC1 | stanniocalcin 1 | 0.0464216 |
| CTTN | cortactin | 0.0461732 |
| RPL19 | ribosomal protein L19 | 0.0459753 |
| SMAD3 | SMAD family member 3 | 0.0457417 |
| RPS12 | ribosomal protein S12 | 0.0452806 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0442812 |
| PLEC | plectin | 0.0437392 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0435546 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0434172 |
| TLN1 | talin 1 | 0.0430236 |
| SVIL | supervillin | 0.0421939 |
| TPI1 | triosephosphate isomerase 1 | 0.0420374 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0412082 |
| HSPA8 | heat shock 70kDa protein 8 | 0.041175 |
| FBXO11 | F-box protein 11 | 0.040648 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0406235 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0406153 |
| TPM3 | tropomyosin 3 | 0.0403409 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0400232 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0394869 |
| HOMER1 | homer scaffolding protein 1 | 0.0394037 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0393985 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0390885 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0386137 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0384771 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0382467 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0382373 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0377201 |
| AEBP2 | AE binding protein 2 | 0.0374168 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0370854 |
| EXOC4 | exocyst complex component 4 | 0.0367974 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0364964 |
| FMNL2 | formin-like 2 | 0.036241 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0354133 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0352451 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0351122 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0349866 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0348921 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0345617 |
| GOLGB1 | golgin B1 | 0.0345088 |
| CDK17 | cyclin-dependent kinase 17 | 0.034225 |
| SESN2 | sestrin 2 | 0.0341708 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0340329 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0339586 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0339047 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0337643 |
| RPL37 | ribosomal protein L37 | 0.0327414 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0326474 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.032607 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0322833 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0321729 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0321306 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0318755 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0318705 |
| SQSTM1 | sequestosome 1 | 0.0318109 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0317592 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0314248 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0314145 |
| MYO10 | myosin X | 0.0311864 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0310739 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0309331 |
| ACTN1 | actinin, alpha 1 | 0.0308858 |
| RPS4X | ribosomal protein S4, X-linked | 0.0306265 |
| RPS3 | ribosomal protein S3 | 0.0303763 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0302953 |
| HYOU1 | hypoxia up-regulated 1 | 0.0301625 |
| ATG7 | autophagy related 7 | 0.0299311 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0295096 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0294955 |
| RPL37A | ribosomal protein L37a | 0.029432 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0291402 |
| MAGEA4 | melanoma antigen family A4 | 0.0290003 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0741274 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0706544 |
| POTEF | POTE ankyrin domain family, member F | -0.055877 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0538635 |
| YBX3 | Y box binding protein 3 | -0.0527074 |
| PFN1 | profilin 1 | -0.0480926 |
| RTN4 | reticulon 4 | -0.0421081 |
| CENPF | centromere protein F, 350/400kDa | -0.0411386 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0383725 |
| MKI67 | marker of proliferation Ki-67 | -0.0376272 |
| BBX | bobby sox homolog (Drosophila) | -0.0371447 |
| ANKRD12 | ankyrin repeat domain 12 | -0.036882 |
| PHIP | pleckstrin homology domain interacting protein | -0.034821 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0340608 |
| ZNF292 | zinc finger protein 292 | -0.0311752 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0288742 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.028326 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0282987 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0279479 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0269451 |
| TMEM165 | transmembrane protein 165 | -0.02569 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0255221 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0251476 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0245472 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0244894 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0242144 |
| DIAPH3 | diaphanous-related formin 3 | -0.0240265 |
| CCNL1 | cyclin L1 | -0.0240049 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0228583 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0228377 |
| PTMA | prothymosin, alpha | -0.0227346 |
| LATS2 | large tumor suppressor kinase 2 | -0.0224595 |
| RBM25 | RNA binding motif protein 25 | -0.0219024 |
| SBF2 | SET binding factor 2 | -0.0214076 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0212234 |
| XPO1 | exportin 1 | -0.0210364 |
| CBX3 | chromobox homolog 3 | -0.020988 |
| ATXN1 | ataxin 1 | -0.0207474 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0207412 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.020682 |
| TAPBP | TAP binding protein (tapasin) | -0.0204594 |
| ANLN | anillin, actin binding protein | -0.0204588 |
| GOLGA4 | golgin A4 | -0.0203879 |
| GNAS | GNAS complex locus | -0.0200999 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0200794 |
| DEK | DEK proto-oncogene | -0.0200021 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.019848 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0197687 |
| SRPK2 | SRSF protein kinase 2 | -0.0196907 |
| RSF1 | remodeling and spacing factor 1 | -0.0193856 |
| CENPE | centromere protein E, 312kDa | -0.0192987 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0191575 |
| THOC2 | THO complex 2 | -0.0189131 |
| SEPTIN7 | septin 7 | -0.0189041 |
| PTEN | phosphatase and tensin homolog | -0.0188574 |
| WDR45B | WD repeat domain 45B | -0.0186127 |
| IGF2 | insulin-like growth factor 2 | -0.0185345 |
| ACTG1 | actin gamma 1 | -0.0184493 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0183725 |
| QKI | QKI, KH domain containing, RNA binding | -0.0175302 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0170128 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0169201 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.016872 |
| MED13L | mediator complex subunit 13-like | -0.0168387 |
| BSG | basigin (Ok blood group) | -0.0167953 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0167524 |
| RPS15 | ribosomal protein S15 | -0.0167361 |
| TPX2 | TPX2, microtubule-associated | -0.0165288 |
| NKTR | natural killer cell triggering receptor | -0.016459 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0163658 |
| CCDC88A | coiled-coil domain containing 88A | -0.0162932 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0162898 |
| SGO2 | shugoshin 2 | -0.0162716 |
| RPS21 | ribosomal protein S21 | -0.0162472 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0161058 |
| RAD51B | RAD51 paralog B | -0.0160619 |
| TMPO | thymopoietin | -0.0159256 |
| RLF | rearranged L-myc fusion | -0.0158688 |
| CEP192 | centrosomal protein 192kDa | -0.0158251 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0158141 |
| RYR3 | ryanodine receptor 3 | -0.0157572 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0157393 |
| TFG | TRK-fused gene | -0.0156261 |
| R3HDM1 | R3H domain containing 1 | -0.0156198 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0155574 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0155154 |
| ZNF654 | zinc finger protein 654 | -0.015455 |
| RIGI | RNA sensor RIG-I | -0.0152263 |
| BMP5 | bone morphogenetic protein 5 | -0.0152141 |
| NLGN1 | neuroligin 1 | -0.0149477 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0149297 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0149074 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0147962 |
| KNL1 | kinetochore scaffold 1 | -0.014787 |
| TNPO3 | transportin 3 | -0.0147784 |
| STXBP3 | syntaxin binding protein 3 | -0.0147685 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0147173 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0147019 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0146151 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0145865 |
