Dabrafenib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dabrafenib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.186913
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.184371
PABPC1 poly(A) binding protein, cytoplasmic 1 0.138689
MYH9 myosin, heavy chain 9, non-muscle 0.130957
IGFBP3 insulin-like growth factor binding protein 3 0.116803
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105741
DSPP dentin sialophosphoprotein 0.103683
PLEC plectin 0.101935
ZSWIM6 zinc finger, SWIM-type containing 6 0.101176
APLP2 amyloid beta (A4) precursor-like protein 2 0.100869
RPL19 ribosomal protein L19 0.100822
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0815035
ARRDC3 arrestin domain containing 3 0.0770353
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0717402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0714093
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0713294
FBXO32 F-box protein 32 0.0668383
TRIO trio Rho guanine nucleotide exchange factor 0.0663605
DTNA dystrobrevin, alpha 0.0650952
LAMB3 laminin, beta 3 0.0650747
EXT1 exostosin glycosyltransferase 1 0.0642355
EEF2 eukaryotic translation elongation factor 2 0.0629462
LDHA lactate dehydrogenase A 0.0597606
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0585692
TPM3 tropomyosin 3 0.0578403
NAV2 neuron navigator 2 0.0576471
MSN moesin 0.0555866
VIM vimentin 0.0555382
EEF1G eukaryotic translation elongation factor 1 gamma 0.0551055
KRT18 keratin 18, type I 0.0545418
GOLGB1 golgin B1 0.054423
FLNA filamin A, alpha 0.0543614
G0S2 G0/G1 switch 2 0.0538806
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0531929
MCL1 myeloid cell leukemia 1 0.0531337
TMSB4X thymosin beta 4, X-linked 0.0528462
HDAC9 histone deacetylase 9 0.052735
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0521566
FNIP1 folliculin interacting protein 1 0.0520346
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0519341
ENO1 enolase 1, (alpha) 0.0519276
RNF213 ring finger protein 213 0.0512155
CALR calreticulin 0.0492872
MX1 MX dynamin-like GTPase 1 0.0487122
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.048134
RPL7 ribosomal protein L7 0.0477419
FN1 fibronectin 1 0.0471207
RPS12 ribosomal protein S12 0.0465933
HSPA8 heat shock 70kDa protein 8 0.0454827
GRB10 growth factor receptor-bound protein 10 0.0450634
CSNK1A1 casein kinase 1, alpha 1 0.0440764
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0430519
EGR1 early growth response 1 0.0420608
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0415572
TACSTD2 tumor-associated calcium signal transducer 2 0.0414271
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0413982
JARID2 jumonji, AT rich interactive domain 2 0.0412116
MAP1B microtubule-associated protein 1B 0.0407886
LAMC2 laminin, gamma 2 0.040535
MYO5B myosin VB 0.039313
CD44 CD44 molecule (Indian blood group) 0.0391321
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0390536
RAB7A RAB7A, member RAS oncogene family 0.0386683
CTSB cathepsin B 0.0385717
KIAA1217 KIAA1217 0.0385262
SEC31A SEC31 homolog A (S. cerevisiae) 0.038312
CANX calnexin 0.0381023
MACF1 microtubule-actin crosslinking factor 1 0.0376319
MYO1E myosin IE 0.0374849
RPS17 ribosomal protein S17 0.0374122
RAI14 retinoic acid induced 14 0.0361767
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0357727
IFI27 interferon, alpha-inducible protein 27 0.0356804
AHNAK2 AHNAK nucleoprotein 2 0.035114
ERBIN erbb2 interacting protein 0.0349811
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0340831
VEGFA vascular endothelial growth factor A 0.0340049
MACC1 metastasis associated in colon cancer 1 0.033898
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0336632
LPP LIM domain containing preferred translocation partner in lipoma 0.0327579
FLNB filamin B, beta 0.032752
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0325599
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.032492
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0323901
RCOR1 REST corepressor 1 0.0321263
MYO10 myosin X 0.0321017
DST dystonin 0.0320342
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0318728
SCFD1 sec1 family domain containing 1 0.0318547
TJP1 tight junction protein 1 0.0317314
SEPTIN9 septin 9 0.0305683
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.030562
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0305166
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0304826
PCBP2 poly(rC) binding protein 2 0.0304575
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0301661
TMF1 TATA element modulatory factor 1 0.0295422
VCL vinculin 0.029472
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0294095
KRT19 keratin 19, type I 0.029001

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236998
NAMPT nicotinamide phosphoribosyltransferase -0.125531
PTMA prothymosin, alpha -0.120854
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111432
ASPH aspartate beta-hydroxylase -0.11052
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.105987
POTEF POTE ankyrin domain family, member F -0.0890879
TM4SF1 transmembrane 4 L six family member 1 -0.07905
ACTG1 actin gamma 1 -0.0772315
TPT1 tumor protein, translationally-controlled 1 -0.0707234
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0679471
RPL35A ribosomal protein L35a -0.0648308
TFG TRK-fused gene -0.0640017
TMSB10 thymosin beta 10 -0.0583344
LMO7 LIM domain 7 -0.0569651
NPEPPS aminopeptidase puromycin sensitive -0.0564896
SLC38A1 solute carrier family 38, member 1 -0.0560103
RPL34 ribosomal protein L34 -0.0556221
MARCHF6 membrane associated ring-CH-type finger 6 -0.0536839
S100A10 S100 calcium binding protein A10 -0.0521346
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0509584
S100A6 S100 calcium binding protein A6 -0.0498307
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0496
RBM39 RNA binding motif protein 39 -0.0493228
GARS1 glycyl-tRNA synthetase 1 -0.0479588
FAM162A family with sequence similarity 162, member A -0.0477032
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0475627
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.045648
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0449664
FAM3C family with sequence similarity 3, member C -0.0438195
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0435931
GNAS GNAS complex locus -0.0433949
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0432353
TMEM263 transmembrane protein 263 -0.0428081
AREG amphiregulin -0.0417416
USP3 ubiquitin specific peptidase 3 -0.0416379
KMT2E lysine (K)-specific methyltransferase 2E -0.0405318
CCNL1 cyclin L1 -0.04052
RPL8 ribosomal protein L8 -0.0404674
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0397539
CD2AP CD2-associated protein -0.0392569
MSMO1 methylsterol monooxygenase 1 -0.0387348
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0385703
CCND1 cyclin D1 -0.0384219
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0374552
FTL ferritin, light polypeptide -0.0374367
TSC22D2 TSC22 domain family, member 2 -0.0365314
RPS6 ribosomal protein S6 -0.0360602
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0360292
SDC4 syndecan 4 -0.0354956
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0354555
RNF145 ring finger protein 145 -0.035215
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0352148
PGK1 phosphoglycerate kinase 1 -0.0350742
TMEM123 transmembrane protein 123 -0.034352
CDK17 cyclin-dependent kinase 17 -0.0343056
RPS24 ribosomal protein S24 -0.0341807
RPS21 ribosomal protein S21 -0.033813
EPCAM epithelial cell adhesion molecule -0.033396
RHEB Ras homolog enriched in brain -0.0330299
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0328712
MATR3 matrin 3 -0.0322207
RPL38 ribosomal protein L38 -0.0316753
PARD3 par-3 family cell polarity regulator -0.0308681
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0308621
ZFAND3 zinc finger, AN1-type domain 3 -0.0304774
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0303349
CCNI cyclin I -0.030199
WSB1 WD repeat and SOCS box containing 1 -0.0301413
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0300903
DEK DEK proto-oncogene -0.0295295
KPNB1 karyopherin (importin) beta 1 -0.0294729
LY6E lymphocyte antigen 6 complex, locus E -0.028687
CDC73 cell division cycle 73 -0.0285533
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0284126
DSCAM Down syndrome cell adhesion molecule -0.0283889
HMGB2 high mobility group box 2 -0.0280357
RAD21 RAD21 homolog (S. pombe) -0.0278752
QKI QKI, KH domain containing, RNA binding -0.027872
S100A9 S100 calcium binding protein A9 -0.0278004
TOP2A topoisomerase (DNA) II alpha 170kDa -0.027787
KDM3A lysine (K)-specific demethylase 3A -0.0273555
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0271546
PRRC1 proline-rich coiled-coil 1 -0.0271387
MORF4L1 mortality factor 4 like 1 -0.0270774
YBX3 Y box binding protein 3 -0.0269486
NPC2 Niemann-Pick disease, type C2 -0.0267998
WTAP Wilms tumor 1 associated protein -0.0266582
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0263
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0260992
RTN4 reticulon 4 -0.0256075
ZNF292 zinc finger protein 292 -0.0254439
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0252213
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0251052
UGCG UDP-glucose ceramide glucosyltransferase -0.0249399
RAB1A RAB1A, member RAS oncogene family -0.0248521
STEAP4 STEAP family member 4 -0.0246979
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0245843
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0244105
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0243476