| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.158951 |
| MCL1 | myeloid cell leukemia 1 | 0.155376 |
| DOCK4 | dedicator of cytokinesis 4 | 0.138921 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.108243 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0871974 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.086048 |
| GRAMD1B | GRAM domain containing 1B | 0.0829618 |
| VIM | vimentin | 0.0825729 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0764016 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.072334 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0720823 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0714511 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0684436 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0637239 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.063381 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0597343 |
| RPL19 | ribosomal protein L19 | 0.0577073 |
| BMP6 | bone morphogenetic protein 6 | 0.0560133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0545174 |
| PYGL | phosphorylase, glycogen, liver | 0.0537848 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0537072 |
| FMNL2 | formin-like 2 | 0.0530074 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0527046 |
| RPS12 | ribosomal protein S12 | 0.0526188 |
| LSAMP | limbic system-associated membrane protein | 0.0522869 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0510646 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0507226 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0497023 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0495717 |
| CDH13 | cadherin 13 | 0.0491631 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0489901 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0475049 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0469054 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0467596 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0465662 |
| RGS2 | regulator of G-protein signaling 2 | 0.0464957 |
| MYO10 | myosin X | 0.0436712 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0430878 |
| RPS8 | ribosomal protein S8 | 0.0428942 |
| RPS27 | ribosomal protein S27 | 0.0428464 |
| STC1 | stanniocalcin 1 | 0.042665 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.040587 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0404942 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0402205 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0400136 |
| RPL26 | ribosomal protein L26 | 0.0399275 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0396311 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0392358 |
| PCBP2 | poly(rC) binding protein 2 | 0.0383676 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.038005 |
| RPL37A | ribosomal protein L37a | 0.0379628 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0375775 |
| SQSTM1 | sequestosome 1 | 0.037054 |
| EZR | ezrin | 0.0366917 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0364758 |
| NRXN3 | neurexin 3 | 0.0361159 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0359233 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0357201 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0353579 |
| RPS4X | ribosomal protein S4, X-linked | 0.0349531 |
| RPL7 | ribosomal protein L7 | 0.0346963 |
| RPS17 | ribosomal protein S17 | 0.0345687 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0345424 |
| FAM107B | family with sequence similarity 107, member B | 0.0343838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0328193 |
| SMAD2 | SMAD family member 2 | 0.0321975 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0316742 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0314685 |
| RPLP1 | ribosomal protein, large, P1 | 0.0311962 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0308523 |
| RPL31 | ribosomal protein L31 | 0.0304741 |
| RPS2 | ribosomal protein S2 | 0.0294228 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0289542 |
| RPL4 | ribosomal protein L4 | 0.0289163 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0283335 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.028075 |
| MSN | moesin | 0.0280633 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.027679 |
| RPL3 | ribosomal protein L3 | 0.027624 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0275355 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0274458 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0272995 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0271158 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0269087 |
| RPL23 | ribosomal protein L23 | 0.0268837 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0265725 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0263981 |
| TPM3 | tropomyosin 3 | 0.0263693 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0263429 |
| INTS6 | integrator complex subunit 6 | 0.0261781 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0260211 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.025411 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0249802 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0247492 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0245481 |
| INHBA | inhibin, beta A | 0.0244347 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0243655 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0242289 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0240913 |
| RPS6 | ribosomal protein S6 | 0.0238381 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.248974 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.108717 |
| SMYD3 | SET and MYND domain containing 3 | -0.107113 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0969675 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0968453 |
| COL5A2 | collagen, type V, alpha 2 | -0.0940575 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0813754 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0808947 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0780322 |
| EFNA5 | ephrin-A5 | -0.0754541 |
| MYOF | myoferlin | -0.0731888 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0657159 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0591631 |
| TXNRD1 | thioredoxin reductase 1 | -0.0544528 |
| GDA | guanine deaminase | -0.0538189 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0537682 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0517852 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.05065 |
| PTGR1 | prostaglandin reductase 1 | -0.0500468 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0485799 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0480597 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0463695 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0449875 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0431829 |
| NCKAP5 | NCK-associated protein 5 | -0.041864 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0416676 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0413252 |
| ASPH | aspartate beta-hydroxylase | -0.0407474 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0399567 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0391339 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0370254 |
| OSMR | oncostatin M receptor | -0.0367229 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0365772 |
| TMSB10 | thymosin beta 10 | -0.0362329 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.035861 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0357989 |
| DPYD | dihydropyrimidine dehydrogenase | -0.035375 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0353471 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0351279 |
| CTSC | cathepsin C | -0.0348597 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0333773 |
| NEK7 | NIMA-related kinase 7 | -0.0325714 |
| PALLD | palladin, cytoskeletal associated protein | -0.0324327 |
| CD109 | CD109 molecule | -0.0305619 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0301444 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0301251 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0295382 |
| S100A6 | S100 calcium binding protein A6 | -0.0290305 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0287622 |
| KIAA0825 | KIAA0825 | -0.0281805 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0267369 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0267127 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0263359 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0262988 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0262654 |
| PTEN | phosphatase and tensin homolog | -0.0261782 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0261574 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.025861 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0251338 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0246338 |
| GNAS | GNAS complex locus | -0.0244519 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0240892 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0240874 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0239706 |
| TENM3 | teneurin transmembrane protein 3 | -0.0238276 |
| RTN1 | reticulon 1 | -0.0236962 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0236826 |
| PCBP3 | poly(rC) binding protein 3 | -0.0234658 |
| NF1 | neurofibromin 1 | -0.0232826 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0230264 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0228432 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0228162 |
| AOPEP | aminopeptidase O (putative) | -0.0227586 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0225569 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0225494 |
| PTMA | prothymosin, alpha | -0.0223912 |
| PDE7B | phosphodiesterase 7B | -0.0222491 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0220161 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0218924 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0218494 |
| HLA-B | major histocompatibility complex, class I, B | -0.0210082 |
| SPAG9 | sperm associated antigen 9 | -0.0209694 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0208809 |
| THOC2 | THO complex 2 | -0.0208367 |
| SRPK2 | SRSF protein kinase 2 | -0.0208189 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0205611 |
| TBC1D19 | TBC1 domain family, member 19 | -0.0204992 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0202941 |
| VCL | vinculin | -0.0199465 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0198921 |
| CENPF | centromere protein F, 350/400kDa | -0.0195642 |
| RTN4 | reticulon 4 | -0.0191183 |
| FRMD4B | FERM domain containing 4B | -0.0189624 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0188753 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0188349 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0187876 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0187761 |
| ADD3 | adducin 3 (gamma) | -0.0187305 |
| MYPN | myopalladin | -0.0185633 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0184555 |
