| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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196 genes differentially expressed following the Dabrafenib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.248282 |
| FN1 | fibronectin 1 | 0.205834 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.160599 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.140236 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.133321 |
| STK39 | serine threonine kinase 39 | 0.132685 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.112047 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.110188 |
| LSAMP | limbic system-associated membrane protein | 0.0989252 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0971047 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0943949 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0921934 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0914079 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.091163 |
| VIM | vimentin | 0.0907098 |
| KLF6 | Kruppel-like factor 6 | 0.0906462 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0885056 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0877797 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0855143 |
| MYO10 | myosin X | 0.0834278 |
| PKM | pyruvate kinase, muscle | 0.0756001 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0710426 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0673314 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0643796 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0627279 |
| APP | amyloid beta (A4) precursor protein | 0.0613439 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0603187 |
| MED13 | mediator complex subunit 13 | 0.060071 |
| HMGA2 | high mobility group AT-hook 2 | 0.0594337 |
| MYO5B | myosin VB | 0.0578642 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0560833 |
| SMAD3 | SMAD family member 3 | 0.0555729 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.055219 |
| INHBA | inhibin, beta A | 0.0542449 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.051566 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.051256 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0507277 |
| MMP1 | matrix metallopeptidase 1 | 0.0505641 |
| AK1 | adenylate kinase 1 | 0.0504021 |
| LAMB3 | laminin, beta 3 | 0.0500154 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0499601 |
| ERBIN | erbb2 interacting protein | 0.049324 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0483987 |
| LDHA | lactate dehydrogenase A | 0.0482638 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0480624 |
| FOXP1 | forkhead box P1 | 0.0476083 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0456028 |
| RPS16 | ribosomal protein S16 | 0.0449937 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0447014 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0439916 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0419284 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0396218 |
| ENO1 | enolase 1, (alpha) | 0.0385245 |
| MAP4 | microtubule-associated protein 4 | 0.0365111 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0332739 |
| FAT1 | FAT atypical cadherin 1 | 0.0321675 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0316856 |
| MORF4L2 | mortality factor 4 like 2 | 0.0315425 |
| MMP12 | matrix metallopeptidase 12 | 0.0311254 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0304911 |
| CD44 | CD44 molecule (Indian blood group) | 0.0284172 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0283709 |
| S100A10 | S100 calcium binding protein A10 | 0.0262927 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0247926 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0239382 |
| SMYD3 | SET and MYND domain containing 3 | 0.0235074 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0229746 |
| ANO6 | anoctamin 6 | 0.0228849 |
| TJP1 | tight junction protein 1 | 0.021974 |
| PTK2 | protein tyrosine kinase 2 | 0.0190244 |
| S100A6 | S100 calcium binding protein A6 | 0.0185675 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0178111 |
| EFNA5 | ephrin-A5 | 0.0168755 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0168055 |
| PRKCA | protein kinase C, alpha | 0.0168047 |
| GLIS3 | GLIS family zinc finger 3 | 0.0165204 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0160324 |
| RACK1 | receptor for activated C kinase 1 | 0.0156264 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0150891 |
| FAM13A | family with sequence similarity 13, member A | 0.0138518 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0127414 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0109418 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0104835 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.00984323 |
| RPS8 | ribosomal protein S8 | 0.00975488 |
| COL5A2 | collagen, type V, alpha 2 | 0.00915348 |
| BMERB1 | bMERB domain containing 1 | 0.00818328 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.00653562 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00644244 |
| RPS12 | ribosomal protein S12 | 0.00501723 |
| JMJD1C | jumonji domain containing 1C | 0.00423267 |
| PGK1 | phosphoglycerate kinase 1 | 0.00127939 |
| RIGI | RNA sensor RIG-I | 0.00120102 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 6.80074E-4 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 5.16973E-4 |
| ZNF292 | zinc finger protein 292 | 3.08952E-5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157385 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.11838 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.110485 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.103466 |
| PARD3 | par-3 family cell polarity regulator | -0.103002 |
| RNF213 | ring finger protein 213 | -0.101997 |
| LAMC2 | laminin, gamma 2 | -0.101822 |
| TMSB10 | thymosin beta 10 | -0.0973069 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.092711 |
| EGR1 | early growth response 1 | -0.0912618 |
| RAD51B | RAD51 paralog B | -0.0910243 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0854336 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0850636 |
| RPL15 | ribosomal protein L15 | -0.08347 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.081721 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0765787 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0758461 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.074438 |
| FRMD5 | FERM domain containing 5 | -0.0713912 |
| EGFR | epidermal growth factor receptor | -0.0680089 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0658692 |
| FHIT | fragile histidine triad | -0.0656336 |
| PTMA | prothymosin, alpha | -0.0651905 |
| ANXA2 | annexin A2 | -0.0629623 |
| CDH13 | cadherin 13 | -0.0629324 |
| ATXN1 | ataxin 1 | -0.0620852 |
| VCL | vinculin | -0.0614693 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.05945 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0593309 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.058643 |
| YAP1 | Yes-associated protein 1 | -0.0584033 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0564444 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0557945 |
| RPS13 | ribosomal protein S13 | -0.0538824 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0538479 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0537924 |
| LAMA4 | laminin, alpha 4 | -0.0535084 |
| TOP1 | topoisomerase (DNA) I | -0.0529432 |
| RPL23 | ribosomal protein L23 | -0.0520416 |
| LMO7 | LIM domain 7 | -0.0518527 |
| FLNB | filamin B, beta | -0.0515578 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0513897 |
| RPL31 | ribosomal protein L31 | -0.0481313 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0480531 |
| CDK13 | cyclin-dependent kinase 13 | -0.0476454 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0474596 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0462851 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0459487 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0456246 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0450859 |
| RPL12 | ribosomal protein L12 | -0.0446138 |
| NDRG1 | N-myc downstream regulated 1 | -0.0439225 |
| RPL37 | ribosomal protein L37 | -0.0432257 |
| CANX | calnexin | -0.0428645 |
| SBF2 | SET binding factor 2 | -0.0427785 |
| PDE10A | phosphodiesterase 10A | -0.0423869 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0418727 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0415663 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0410597 |
| SLTM | SAFB-like, transcription modulator | -0.0406937 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0403414 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0393823 |
| NABP1 | nucleic acid binding protein 1 | -0.0393265 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0370433 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0364942 |
| MYO1E | myosin IE | -0.0356059 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0355597 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0352488 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0349998 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.033903 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0337723 |
| PRELID2 | PRELI domain containing 2 | -0.033611 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0333504 |
| CNKSR3 | CNKSR family member 3 | -0.0331683 |
| GPC6 | glypican 6 | -0.0330062 |
| RUNX1 | runt-related transcription factor 1 | -0.0327944 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0327185 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0324636 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0317261 |
| ASPH | aspartate beta-hydroxylase | -0.0309485 |
| PCBP2 | poly(rC) binding protein 2 | -0.0303361 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0300873 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0295325 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0288891 |
| FTL | ferritin, light polypeptide | -0.0281883 |
| CALU | calumenin | -0.028173 |
| MYOF | myoferlin | -0.0262766 |
| GOLGA4 | golgin A4 | -0.0252285 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0241436 |
| STK24 | serine/threonine kinase 24 | -0.0240052 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0221617 |
| NRG1 | neuregulin 1 | -0.0209021 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0204862 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0202347 |
| TPM4 | tropomyosin 4 | -0.0202176 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0187734 |
| ACTG1 | actin gamma 1 | -0.0186457 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0184992 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0167352 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0161837 |
