| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.229412 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.140648 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.129636 |
| VIM | vimentin | 0.1233 |
| CADM2 | cell adhesion molecule 2 | 0.111184 |
| HDAC9 | histone deacetylase 9 | 0.109571 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.108388 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0939402 |
| PCDH9 | protocadherin 9 | 0.0866665 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0853601 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0835754 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0820615 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0752592 |
| COL5A2 | collagen, type V, alpha 2 | 0.0746918 |
| ITGAV | integrin, alpha V | 0.0723688 |
| NTM | neurotrimin | 0.0648022 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0630798 |
| NHSL1 | NHS-like 1 | 0.0616575 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0612533 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0607902 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0585868 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0583274 |
| CALR | calreticulin | 0.0576768 |
| HMCN1 | hemicentin 1 | 0.0537059 |
| PARD3B | par-3 family cell polarity regulator beta | 0.053198 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0524244 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.052147 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0509861 |
| PCDH18 | protocadherin 18 | 0.0509067 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0479409 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0479183 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0478366 |
| COL3A1 | collagen, type III, alpha 1 | 0.0458765 |
| TPM3 | tropomyosin 3 | 0.0453647 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0444573 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0440316 |
| PRELID2 | PRELI domain containing 2 | 0.0438313 |
| RPL19 | ribosomal protein L19 | 0.0431319 |
| RPL3 | ribosomal protein L3 | 0.0424182 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0413866 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0410477 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0403207 |
| SCFD1 | sec1 family domain containing 1 | 0.0397308 |
| FOXG1 | forkhead box G1 | 0.0395266 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0394912 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0392719 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0386333 |
| RPL7 | ribosomal protein L7 | 0.0383665 |
| APP | amyloid beta (A4) precursor protein | 0.0378 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0376477 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0374688 |
| UTRN | utrophin | 0.037368 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0366999 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.036546 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0363197 |
| GPC4 | glypican 4 | 0.0348548 |
| TOX | thymocyte selection-associated high mobility group box | 0.0348377 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0341732 |
| PCDH7 | protocadherin 7 | 0.0337996 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0331245 |
| ENO1 | enolase 1, (alpha) | 0.0331107 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0328052 |
| ANXA1 | annexin A1 | 0.0325947 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.032586 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.032553 |
| TENM2 | teneurin transmembrane protein 2 | 0.0324998 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.032219 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0321516 |
| PEG10 | paternally expressed 10 | 0.0321363 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0320685 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0318683 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0317259 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0316581 |
| MYO10 | myosin X | 0.0316513 |
| LDHA | lactate dehydrogenase A | 0.0316291 |
| GPHN | gephyrin | 0.0316133 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0306208 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0301065 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.029889 |
| CANX | calnexin | 0.029743 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0296287 |
| NRDC | nardilysin convertase | 0.0293972 |
| RAD51B | RAD51 paralog B | 0.02898 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0285732 |
| LRRC4C | leucine rich repeat containing 4C | 0.0283938 |
| RPS2 | ribosomal protein S2 | 0.028388 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0283519 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.0281208 |
| JMJD1C | jumonji domain containing 1C | 0.028109 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0272327 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0271591 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0270307 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0266051 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.0265873 |
| CDH19 | cadherin 19, type 2 | 0.0265055 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0264843 |
| PGK1 | phosphoglycerate kinase 1 | 0.0264073 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0263621 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0263522 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0258341 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0980862 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0669312 |
| FOXP2 | forkhead box P2 | -0.0657745 |
| USP3 | ubiquitin specific peptidase 3 | -0.0651762 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0595227 |
| RBM25 | RNA binding motif protein 25 | -0.0580104 |
| PTMA | prothymosin, alpha | -0.0536417 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.050919 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0480861 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0476231 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0470765 |
| CENPE | centromere protein E, 312kDa | -0.0465567 |
| RTN4 | reticulon 4 | -0.0461124 |
| SPAG9 | sperm associated antigen 9 | -0.0456855 |
| PFN1 | profilin 1 | -0.0452833 |
| RPS27A | ribosomal protein S27a | -0.0450342 |
| CAVIN1 | caveolae associated protein 1 | -0.0446608 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0443042 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0436529 |
| ACTG1 | actin gamma 1 | -0.0422679 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0420588 |
| ZNF292 | zinc finger protein 292 | -0.0410464 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0407796 |
| GNAS | GNAS complex locus | -0.0406874 |
| RPS16 | ribosomal protein S16 | -0.0400304 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0397702 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0395221 |
| HMGB1 | high mobility group box 1 | -0.0393328 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0387153 |
| MTF2 | metal response element binding transcription factor 2 | -0.0385955 |
| FBXO11 | F-box protein 11 | -0.0377285 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0369171 |
| KIF4A | kinesin family member 4A | -0.036784 |
| RPLP1 | ribosomal protein, large, P1 | -0.0366731 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0363367 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0361432 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0359998 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.035721 |
| RLF | rearranged L-myc fusion | -0.0356005 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0354949 |
| BBX | bobby sox homolog (Drosophila) | -0.0354587 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0352088 |
| TXNRD1 | thioredoxin reductase 1 | -0.0348739 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0347356 |
| WDR43 | WD repeat domain 43 | -0.0347351 |
| COG5 | component of oligomeric golgi complex 5 | -0.0347074 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0340516 |
| RPL35A | ribosomal protein L35a | -0.0333998 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.033241 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0331923 |
| RPS21 | ribosomal protein S21 | -0.0331693 |
| H1-0 | H1.0 linker histone | -0.033097 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0329723 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0325333 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0323867 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.031987 |
| TTK | TTK protein kinase | -0.0318357 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0315383 |
| EMP1 | epithelial membrane protein 1 | -0.0314064 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0313076 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0310379 |
| DEK | DEK proto-oncogene | -0.0310379 |
| TMEM123 | transmembrane protein 123 | -0.0304604 |
| USP12 | ubiquitin specific peptidase 12 | -0.0303491 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.030239 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0302261 |
| ZNF385D | zinc finger protein 385D | -0.0300184 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0297588 |
| RBM39 | RNA binding motif protein 39 | -0.0295006 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0292243 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0290546 |
| AK1 | adenylate kinase 1 | -0.0288864 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0287776 |
| RPS24 | ribosomal protein S24 | -0.0287503 |
| SHROOM3 | shroom family member 3 | -0.0286463 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0276343 |
| RPS13 | ribosomal protein S13 | -0.0276293 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0274749 |
| DST | dystonin | -0.0273428 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0272233 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0271243 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0270711 |
| ASTN2 | astrotactin 2 | -0.0270662 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0270508 |
| ECT2 | epithelial cell transforming 2 | -0.0268784 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0267851 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0266485 |
| RHEB | Ras homolog enriched in brain | -0.0266202 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0265497 |
| ZNF207 | zinc finger protein 207 | -0.0265145 |
| PDGFC | platelet derived growth factor C | -0.0264611 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0264423 |
| ENAH | enabled homolog (Drosophila) | -0.026282 |
| LATS2 | large tumor suppressor kinase 2 | -0.0261519 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0260851 |
| ANK2 | ankyrin 2, neuronal | -0.0260225 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0259482 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0259354 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0259137 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0259129 |
