| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dabrafenib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.172453 |
| TMSB4X | thymosin beta 4, X-linked | 0.161194 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.153121 |
| VCL | vinculin | 0.127717 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.126654 |
| EZR | ezrin | 0.123409 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.119616 |
| FLNB | filamin B, beta | 0.116892 |
| PKM | pyruvate kinase, muscle | 0.114901 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.10868 |
| EGFR | epidermal growth factor receptor | 0.0950948 |
| TJP1 | tight junction protein 1 | 0.0930466 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0882123 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0823312 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0694534 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0693106 |
| AHNAK | AHNAK nucleoprotein | 0.0664213 |
| ANXA1 | annexin A1 | 0.063838 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0595702 |
| DUSP4 | dual specificity phosphatase 4 | 0.0592486 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0591941 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0581259 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0568915 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0565865 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0562859 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0554359 |
| PYGB | phosphorylase, glycogen; brain | 0.0542665 |
| HDAC9 | histone deacetylase 9 | 0.0532085 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0510163 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0509427 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0502001 |
| LDHA | lactate dehydrogenase A | 0.0501523 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0491996 |
| RPL7 | ribosomal protein L7 | 0.0488908 |
| LOXL3 | lysyl oxidase-like 3 | 0.048496 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.046493 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0457388 |
| ECT2 | epithelial cell transforming 2 | 0.0451513 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0451046 |
| RPL3 | ribosomal protein L3 | 0.0445167 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0438293 |
| TXNRD1 | thioredoxin reductase 1 | 0.0437307 |
| MYO5C | myosin VC | 0.0435033 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0430873 |
| PDGFC | platelet derived growth factor C | 0.04291 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0424723 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0423209 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0413147 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0410645 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0407081 |
| FER1L6 | fer-1-like family member 6 | 0.0403285 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0401825 |
| MYOF | myoferlin | 0.0393459 |
| ATP9B | ATPase, class II, type 9B | 0.0389321 |
| ENO1 | enolase 1, (alpha) | 0.0388504 |
| DUSP6 | dual specificity phosphatase 6 | 0.0388074 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.03853 |
| RPL19 | ribosomal protein L19 | 0.0384758 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0383993 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0368828 |
| HDLBP | high density lipoprotein binding protein | 0.036196 |
| RPL4 | ribosomal protein L4 | 0.0357852 |
| MKI67 | marker of proliferation Ki-67 | 0.0354302 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0348499 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.034498 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0344509 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0343986 |
| HJURP | Holliday junction recognition protein | 0.033779 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0334768 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0334311 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0332057 |
| ARHGAP25 | Rho GTPase activating protein 25 | 0.0331008 |
| ZNF608 | zinc finger protein 608 | 0.0330066 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0326207 |
| SQSTM1 | sequestosome 1 | 0.0324857 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0324749 |
| PGK1 | phosphoglycerate kinase 1 | 0.0320062 |
| FBLN2 | fibulin 2 | 0.0317279 |
| FAT1 | FAT atypical cadherin 1 | 0.0315511 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0308268 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0304134 |
| AMOTL2 | angiomotin like 2 | 0.0298862 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0292246 |
| SEPTIN9 | septin 9 | 0.0292059 |
| ANLN | anillin, actin binding protein | 0.0291588 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0288254 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0286845 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0285362 |
| RTN4 | reticulon 4 | 0.0284326 |
| KIF5B | kinesin family member 5B | 0.0281738 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0277364 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0276112 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0274892 |
| PLK2 | polo-like kinase 2 | 0.0271073 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.0268607 |
| BMP2K | BMP2 inducible kinase | 0.0265027 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0259664 |
| CORO1C | coronin, actin binding protein, 1C | 0.0258476 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | 0.0257231 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0257001 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.110334 |
| RPS6 | ribosomal protein S6 | -0.0841852 |
| RPL35A | ribosomal protein L35a | -0.0805235 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0780999 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0670002 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0641378 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0555786 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0546009 |
| RPL31 | ribosomal protein L31 | -0.0484192 |
| RPL9 | ribosomal protein L9 | -0.0457826 |
| RPL37A | ribosomal protein L37a | -0.0444344 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0433893 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0426049 |
| VIM | vimentin | -0.0423035 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0420429 |
| RPS19 | ribosomal protein S19 | -0.0398284 |
| TMSB10 | thymosin beta 10 | -0.0383394 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0370242 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0366219 |
| FTL | ferritin, light polypeptide | -0.0350655 |
| PFN1 | profilin 1 | -0.0337185 |
| RPLP2 | ribosomal protein, large, P2 | -0.0327653 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0324974 |
| RPS13 | ribosomal protein S13 | -0.0324041 |
| NFIA | nuclear factor I/A | -0.0322142 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0321653 |
| FUS | FUS RNA binding protein | -0.0321377 |
| S100A9 | S100 calcium binding protein A9 | -0.0313403 |
| RPS27A | ribosomal protein S27a | -0.0295258 |
| FHIT | fragile histidine triad | -0.0294134 |
| HLA-B | major histocompatibility complex, class I, B | -0.0286892 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0279538 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0275685 |
| PDE10A | phosphodiesterase 10A | -0.0272865 |
| RPS29 | ribosomal protein S29 | -0.027191 |
| RPS21 | ribosomal protein S21 | -0.0266244 |
| RPS3 | ribosomal protein S3 | -0.0265376 |
| GNAS | GNAS complex locus | -0.0263349 |
| TUT4 | terminal uridylyl transferase 4 | -0.0256608 |
| POTEF | POTE ankyrin domain family, member F | -0.0254106 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0253421 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0250984 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0249339 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0242695 |
| EVI5 | ecotropic viral integration site 5 | -0.023508 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0232969 |
| ANKRD12 | ankyrin repeat domain 12 | -0.023014 |
| RPL36 | ribosomal protein L36 | -0.0228335 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0224337 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0223393 |
| NDRG1 | N-myc downstream regulated 1 | -0.0223357 |
| MT2A | metallothionein 2A | -0.0223332 |
| ACTG1 | actin gamma 1 | -0.0217881 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0217641 |
| RPLP1 | ribosomal protein, large, P1 | -0.0217422 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0217318 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0216019 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0212896 |
| RPS14 | ribosomal protein S14 | -0.0207309 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0207168 |
| RPS10 | ribosomal protein S10 | -0.0204995 |
| RPL38 | ribosomal protein L38 | -0.0204371 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0204293 |
| RAD51B | RAD51 paralog B | -0.0201585 |
| FN1 | fibronectin 1 | -0.0200699 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0198791 |
| RPS15 | ribosomal protein S15 | -0.0198014 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0197651 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0194725 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.019357 |
| MSI2 | musashi RNA-binding protein 2 | -0.019305 |
| WDR45B | WD repeat domain 45B | -0.0191668 |
| RPL34 | ribosomal protein L34 | -0.0189487 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0188481 |
| APLF | aprataxin and PNKP like factor | -0.0188406 |
| INTS6 | integrator complex subunit 6 | -0.0186609 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0185439 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0183891 |
| DENND4A | DENN/MADD domain containing 4A | -0.0180976 |
| NEBL | nebulette | -0.0180912 |
| RPS8 | ribosomal protein S8 | -0.018039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0176228 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0176135 |
| RPS23 | ribosomal protein S23 | -0.0175029 |
| SERF2 | small EDRK-rich factor 2 | -0.017424 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0173802 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.017365 |
| RPS25 | ribosomal protein S25 | -0.0171352 |
| RPL23 | ribosomal protein L23 | -0.0169749 |
| RPL11 | ribosomal protein L11 | -0.0169693 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0168833 |
| NBEAL1 | neurobeachin-like 1 | -0.016788 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0167232 |
| THOC2 | THO complex 2 | -0.0165883 |
| PMM2 | phosphomannomutase 2 | -0.0165369 |
| RYR2 | ryanodine receptor 2 (cardiac) | -0.0163607 |
| FAM193A | family with sequence similarity 193, member A | -0.0163377 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0162782 |
| COX5B | cytochrome c oxidase subunit Vb | -0.0162022 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0160763 |
