| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dabrafenib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.325752 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.15168 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.142542 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.126354 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0895348 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0894768 |
| HDAC9 | histone deacetylase 9 | 0.0883174 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0841177 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.074917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0745581 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0729263 |
| RPS12 | ribosomal protein S12 | 0.0678415 |
| FLNA | filamin A, alpha | 0.0676054 |
| RPL19 | ribosomal protein L19 | 0.0675095 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0639839 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0639488 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0625282 |
| CALR | calreticulin | 0.0601057 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0581185 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0561495 |
| LDHA | lactate dehydrogenase A | 0.0503791 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0490774 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.047208 |
| INTS6 | integrator complex subunit 6 | 0.0466742 |
| GOLGB1 | golgin B1 | 0.0454746 |
| RPL7 | ribosomal protein L7 | 0.0453335 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0444301 |
| HLA-E | major histocompatibility complex, class I, E | 0.0438931 |
| SFTPA2 | surfactant protein A2 | 0.0438835 |
| MT2A | metallothionein 2A | 0.0435173 |
| LOXL2 | lysyl oxidase-like 2 | 0.0434059 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0429223 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0425348 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0418787 |
| RPS4X | ribosomal protein S4, X-linked | 0.0415647 |
| VEGFA | vascular endothelial growth factor A | 0.0412004 |
| HLA-A | major histocompatibility complex, class I, A | 0.0389676 |
| CANX | calnexin | 0.0387489 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.03863 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.038472 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.035318 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0346549 |
| RPS8 | ribosomal protein S8 | 0.0346266 |
| MYO10 | myosin X | 0.0336038 |
| MCL1 | myeloid cell leukemia 1 | 0.0323293 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0310174 |
| RPS3 | ribosomal protein S3 | 0.0307094 |
| SQSTM1 | sequestosome 1 | 0.0287304 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0286165 |
| RPL37A | ribosomal protein L37a | 0.0284718 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0283597 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0278575 |
| PLIN2 | perilipin 2 | 0.0268023 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.026737 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0266489 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0263333 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0261268 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0259861 |
| STC2 | stanniocalcin 2 | 0.0250318 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0249348 |
| CEP250 | centrosomal protein 250kDa | 0.0248626 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0248077 |
| ASPH | aspartate beta-hydroxylase | 0.0247074 |
| PGM3 | phosphoglucomutase 3 | 0.0246151 |
| RPL4 | ribosomal protein L4 | 0.0245284 |
| APP | amyloid beta (A4) precursor protein | 0.0245032 |
| RPL23 | ribosomal protein L23 | 0.0238179 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0235668 |
| RPS17 | ribosomal protein S17 | 0.0235233 |
| RPL13A | ribosomal protein L13a | 0.0234467 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0232991 |
| RPS25 | ribosomal protein S25 | 0.0232484 |
| SVIL | supervillin | 0.0232342 |
| LASP1 | LIM and SH3 protein 1 | 0.0231871 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0225803 |
| PCBP2 | poly(rC) binding protein 2 | 0.0223677 |
| RACK1 | receptor for activated C kinase 1 | 0.0222772 |
| TUT7 | terminal uridylyl transferase 7 | 0.0221869 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0221437 |
| BRD2 | bromodomain containing 2 | 0.0219624 |
| RPL11 | ribosomal protein L11 | 0.0219059 |
| CDH13 | cadherin 13 | 0.0218476 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0215399 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0214861 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0214509 |
| ENO1 | enolase 1, (alpha) | 0.0214226 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0212251 |
| RPS20 | ribosomal protein S20 | 0.0212228 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0209228 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0208872 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0208087 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.020686 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0204784 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0198167 |
| STC1 | stanniocalcin 1 | 0.0197967 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0197729 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0197228 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0195301 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0194545 |
| RPL5 | ribosomal protein L5 | 0.0194534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.265933 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.222199 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.108225 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.104507 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.100388 |
| DST | dystonin | -0.0956092 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0951203 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0828927 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0758449 |
| GLIS3 | GLIS family zinc finger 3 | -0.0741842 |
| BICC1 | BicC family RNA binding protein 1 | -0.0729458 |
| RTN4 | reticulon 4 | -0.0708986 |
| IER3 | immediate early response 3 | -0.0708476 |
| ZNF292 | zinc finger protein 292 | -0.0694624 |
| PDE10A | phosphodiesterase 10A | -0.0662128 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0657492 |
| COL1A1 | collagen, type I, alpha 1 | -0.0653595 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0635993 |
| CADM1 | cell adhesion molecule 1 | -0.0614108 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.060365 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0577105 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.057673 |
| THBS1 | thrombospondin 1 | -0.0568137 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0561607 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0556192 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0543146 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0539221 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0539051 |
| VCAN | versican | -0.0533911 |
| TNS3 | tensin 3 | -0.0514236 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0514099 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0504617 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0488176 |
| ATP13A3 | ATPase type 13A3 | -0.0487502 |
| RAI14 | retinoic acid induced 14 | -0.0483227 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0476159 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0460372 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0459038 |
| PHF21A | PHD finger protein 21A | -0.0454632 |
| MYOF | myoferlin | -0.0453597 |
| SBF2 | SET binding factor 2 | -0.0450551 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0441727 |
| RBM39 | RNA binding motif protein 39 | -0.0440755 |
| VMP1 | vacuole membrane protein 1 | -0.0432764 |
| FRMD5 | FERM domain containing 5 | -0.0429995 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0429948 |
| GNAS | GNAS complex locus | -0.0427713 |
| AHNAK | AHNAK nucleoprotein | -0.0426736 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0425723 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0422342 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0420116 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0414063 |
| DIAPH2 | diaphanous-related formin 2 | -0.0407203 |
| TMSB10 | thymosin beta 10 | -0.0404342 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0394305 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0393543 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0389462 |
| FN1 | fibronectin 1 | -0.0385618 |
| CTSD | cathepsin D | -0.0385457 |
| VCL | vinculin | -0.0381456 |
| TENM2 | teneurin transmembrane protein 2 | -0.0379681 |
| QKI | QKI, KH domain containing, RNA binding | -0.0376113 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0374605 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0359001 |
| THOC2 | THO complex 2 | -0.0356163 |
| COL1A2 | collagen, type I, alpha 2 | -0.0355252 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.035365 |
| OSMR | oncostatin M receptor | -0.035237 |
| HLA-B | major histocompatibility complex, class I, B | -0.035103 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0350763 |
| LRRC7 | leucine rich repeat containing 7 | -0.0350032 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0337438 |
| JMJD1C | jumonji domain containing 1C | -0.0326549 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0324015 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0321597 |
| CCNL1 | cyclin L1 | -0.0319846 |
| PTMA | prothymosin, alpha | -0.0319162 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0310821 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0308809 |
| NF1 | neurofibromin 1 | -0.0308003 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0307706 |
| PRR16 | proline rich 16 | -0.0307229 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0307072 |
| FBXO32 | F-box protein 32 | -0.0306664 |
| RIGI | RNA sensor RIG-I | -0.0304509 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0302654 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0299512 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0298575 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0297689 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0297655 |
| WTAP | Wilms tumor 1 associated protein | -0.0290356 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0286702 |
| CD2AP | CD2-associated protein | -0.0285982 |
| RUNX2 | runt-related transcription factor 2 | -0.0285557 |
| SMYD3 | SET and MYND domain containing 3 | -0.0284039 |
| BNC2 | basonuclin 2 | -0.0283756 |
| TXNRD1 | thioredoxin reductase 1 | -0.027952 |
| MAP4 | microtubule-associated protein 4 | -0.027938 |
| NAV1 | neuron navigator 1 | -0.0278994 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0275823 |
