| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dabrafenib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.324072 |
| VIM | vimentin | 0.202005 |
| COL6A3 | collagen, type VI, alpha 3 | 0.198335 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.19536 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.148134 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.133924 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.133881 |
| STC1 | stanniocalcin 1 | 0.115127 |
| FN1 | fibronectin 1 | 0.108146 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.101907 |
| CALR | calreticulin | 0.101464 |
| CDH13 | cadherin 13 | 0.0990709 |
| CANX | calnexin | 0.0960561 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0874093 |
| CD44 | CD44 molecule (Indian blood group) | 0.0861134 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0857852 |
| LOXL2 | lysyl oxidase-like 2 | 0.0838813 |
| NRXN3 | neurexin 3 | 0.0834545 |
| ENO1 | enolase 1, (alpha) | 0.0831921 |
| MT2A | metallothionein 2A | 0.0794621 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0793351 |
| KYNU | kynureninase | 0.0780899 |
| MCL1 | myeloid cell leukemia 1 | 0.0748062 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.073754 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0707544 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0683195 |
| HLA-A | major histocompatibility complex, class I, A | 0.0645684 |
| EGFR | epidermal growth factor receptor | 0.0634077 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0626305 |
| B2M | beta-2-microglobulin | 0.061165 |
| HDLBP | high density lipoprotein binding protein | 0.0609872 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0605175 |
| VEGFA | vascular endothelial growth factor A | 0.060424 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.060028 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0599275 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0597942 |
| FLNA | filamin A, alpha | 0.0576708 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0553858 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0526561 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0522786 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0503633 |
| CALU | calumenin | 0.048045 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0472594 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0461076 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0458921 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0455105 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0452726 |
| PLEC | plectin | 0.0451408 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0451222 |
| MSN | moesin | 0.044811 |
| LDHA | lactate dehydrogenase A | 0.0447519 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0444826 |
| ECE1 | endothelin converting enzyme 1 | 0.0443746 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0440399 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0437952 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0431908 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0430503 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0426169 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0421299 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0418126 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0414824 |
| IL6 | interleukin 6 | 0.041291 |
| COL5A1 | collagen, type V, alpha 1 | 0.0412738 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0402851 |
| PRELID2 | PRELI domain containing 2 | 0.0401946 |
| RPL37A | ribosomal protein L37a | 0.0393154 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0392417 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0378683 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0377833 |
| RAD51B | RAD51 paralog B | 0.0377821 |
| NAV1 | neuron navigator 1 | 0.0376225 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0375043 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0365698 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0361838 |
| ATXN1 | ataxin 1 | 0.0361212 |
| GOLGB1 | golgin B1 | 0.0360208 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0357463 |
| SEPTIN9 | septin 9 | 0.0356769 |
| RPL19 | ribosomal protein L19 | 0.0352989 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0350889 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0349899 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0344032 |
| FNIP1 | folliculin interacting protein 1 | 0.034186 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0333256 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.03318 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0327557 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0325913 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0322961 |
| MYO10 | myosin X | 0.0322046 |
| PRKCA | protein kinase C, alpha | 0.0322031 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.031983 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0312869 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0310126 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0309978 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0308747 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0305269 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.030428 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0296621 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0294232 |
| RUNX1 | runt-related transcription factor 1 | 0.0289376 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LOX | lysyl oxidase | -0.0377314 |
| SRPK2 | SRSF protein kinase 2 | -0.0358506 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0357159 |
| TMSB10 | thymosin beta 10 | -0.0352451 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0339581 |
| MT1X | metallothionein 1X | -0.0332038 |
| RBM39 | RNA binding motif protein 39 | -0.0318412 |
| OGA | O-GlcNAcase | -0.0305646 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0302407 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0290219 |
| RBM25 | RNA binding motif protein 25 | -0.0289924 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0286702 |
| ZNF292 | zinc finger protein 292 | -0.0278323 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0274184 |
| RTN4 | reticulon 4 | -0.0273358 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0270997 |
| MATR3 | matrin 3 | -0.0256163 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0255841 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0254922 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.0252091 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0251685 |
| MEF2A | myocyte enhancer factor 2A | -0.0250139 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.02496 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0248983 |
| H3-3B | H3.3 histone B | -0.0243133 |
| WTAP | Wilms tumor 1 associated protein | -0.0239447 |
| CUL3 | cullin 3 | -0.023827 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0233717 |
| COL1A1 | collagen, type I, alpha 1 | -0.0231591 |
| ZHX3 | zinc fingers and homeoboxes 3 | -0.0231438 |
| CFDP1 | craniofacial development protein 1 | -0.0224744 |
| CD2AP | CD2-associated protein | -0.0221034 |
| RASAL2 | RAS protein activator like 2 | -0.0214802 |
| TFG | TRK-fused gene | -0.0214101 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0212182 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0212162 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0209967 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0209711 |
| NKTR | natural killer cell triggering receptor | -0.0205287 |
| SERF2 | small EDRK-rich factor 2 | -0.0205026 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0204999 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.0201675 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0201592 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0200457 |
| SUCO | SUN domain containing ossification factor | -0.0200385 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0197929 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0195326 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0195072 |
| CDK7 | cyclin-dependent kinase 7 | -0.0189357 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0188731 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.018683 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0186674 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0186217 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0178932 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0178356 |
| FOXJ3 | forkhead box J3 | -0.0175369 |
| MED15 | mediator complex subunit 15 | -0.0174428 |
| TAGLN2 | transgelin 2 | -0.0170701 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0168722 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0167947 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0166982 |
| RNF24 | ring finger protein 24 | -0.0166714 |
| WRN | Werner syndrome, RecQ helicase-like | -0.0166575 |
| FOCAD | focadhesin | -0.016609 |
| WDR36 | WD repeat domain 36 | -0.0165753 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0164854 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0164261 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0163036 |
| ZMYM5 | zinc finger, MYM-type 5 | -0.0160251 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | -0.015846 |
| ZNF592 | zinc finger protein 592 | -0.0158129 |
| OSMR | oncostatin M receptor | -0.0157466 |
| DENND5B | DENN/MADD domain containing 5B | -0.0155836 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0155682 |
| WDR45B | WD repeat domain 45B | -0.0154998 |
| AOPEP | aminopeptidase O (putative) | -0.0154232 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0154212 |
| WNT5B | wingless-type MMTV integration site family, member 5B | -0.0153834 |
| COL1A2 | collagen, type I, alpha 2 | -0.01536 |
| NUP54 | nucleoporin 54kDa | -0.0152824 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0152455 |
| CPNE8 | copine VIII | -0.0152392 |
| RIC1 | RAB6A GEF complex partner 1 | -0.0151414 |
| SCFD2 | sec1 family domain containing 2 | -0.0150966 |
| PALLD | palladin, cytoskeletal associated protein | -0.0150104 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0149472 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0148554 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0148298 |
| FAM222B | family with sequence similarity 222, member B | -0.0147824 |
| KLHDC10 | kelch domain containing 10 | -0.0147697 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | -0.0147688 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0147577 |
| WBP11 | WW domain binding protein 11 | -0.0147032 |
| DNMBP | dynamin binding protein | -0.0147003 |
| FUS | FUS RNA binding protein | -0.0145961 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0145493 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0144789 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0144026 |
| TNPO1 | transportin 1 | -0.0143824 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0143638 |
