| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dabrafenib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dabrafenib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.145801 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.134468 |
| VIM | vimentin | 0.132689 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.125897 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.121833 |
| CD44 | CD44 molecule (Indian blood group) | 0.115638 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0994365 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0969456 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0939074 |
| FMNL2 | formin-like 2 | 0.0907464 |
| ANGPTL4 | angiopoietin-like 4 | 0.0863353 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0804032 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0763372 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.07397 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0720695 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0718181 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0709614 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0706673 |
| ASPH | aspartate beta-hydroxylase | 0.0691155 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0667105 |
| LDHA | lactate dehydrogenase A | 0.0637171 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0636253 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0630307 |
| SQSTM1 | sequestosome 1 | 0.0615906 |
| MCL1 | myeloid cell leukemia 1 | 0.0599711 |
| SMAD3 | SMAD family member 3 | 0.059062 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0589556 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.058837 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0583393 |
| MSN | moesin | 0.0566099 |
| FLNA | filamin A, alpha | 0.0556326 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0549577 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0549328 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.054556 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0539387 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0533368 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0515562 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0515194 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0508998 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0506554 |
| ANXA1 | annexin A1 | 0.0492623 |
| MYO10 | myosin X | 0.0492582 |
| ANXA2 | annexin A2 | 0.0488703 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0484203 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0477906 |
| COG5 | component of oligomeric golgi complex 5 | 0.0475811 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0471819 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0464946 |
| RPL19 | ribosomal protein L19 | 0.0463704 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0460281 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0454468 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0453834 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.044715 |
| MT2A | metallothionein 2A | 0.0442895 |
| SVIL | supervillin | 0.0438996 |
| PYGL | phosphorylase, glycogen, liver | 0.0435083 |
| CALR | calreticulin | 0.0428204 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0413846 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0411793 |
| TUT7 | terminal uridylyl transferase 7 | 0.0410702 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0407418 |
| TMSB10 | thymosin beta 10 | 0.0401715 |
| MMP10 | matrix metallopeptidase 10 | 0.0400298 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.039371 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0393033 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0387189 |
| PLEC | plectin | 0.0381403 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.037773 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0377011 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.037539 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0373224 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0372028 |
| MYO9B | myosin IXB | 0.0369359 |
| B2M | beta-2-microglobulin | 0.0367441 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0353114 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.034942 |
| DUSP6 | dual specificity phosphatase 6 | 0.0347531 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0347507 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0347436 |
| SETX | senataxin | 0.0339467 |
| ENO1 | enolase 1, (alpha) | 0.0338923 |
| HBEGF | heparin-binding EGF-like growth factor | 0.0338759 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0336074 |
| CTTN | cortactin | 0.033376 |
| RPS12 | ribosomal protein S12 | 0.0331763 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0330163 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0328803 |
| CANX | calnexin | 0.0328424 |
| GOLGB1 | golgin B1 | 0.0322454 |
| ACTN1 | actinin, alpha 1 | 0.0321042 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0320211 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0318395 |
| ARRDC3 | arrestin domain containing 3 | 0.03172 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0316429 |
| RPS17 | ribosomal protein S17 | 0.031223 |
| SDC4 | syndecan 4 | 0.0310561 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0309367 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0308242 |
| LAMB1 | laminin, beta 1 | 0.0306959 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.030381 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253184 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0665041 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.042016 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0414416 |
| RBM39 | RNA binding motif protein 39 | -0.0397213 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0371157 |
| SNX14 | sorting nexin 14 | -0.0354804 |
| FUS | FUS RNA binding protein | -0.0346833 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0322661 |
| NAV2 | neuron navigator 2 | -0.0314833 |
| HMGA2 | high mobility group AT-hook 2 | -0.0312462 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0311373 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0302788 |
| RAD51B | RAD51 paralog B | -0.0288761 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0283621 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0283473 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0279644 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0269229 |
| EGR1 | early growth response 1 | -0.0262688 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.026263 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0261633 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0258512 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0254052 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0253138 |
| ZNF609 | zinc finger protein 609 | -0.0248337 |
| CENPE | centromere protein E, 312kDa | -0.0242043 |
| COL5A1 | collagen, type V, alpha 1 | -0.0239679 |
| ATXN1 | ataxin 1 | -0.0235408 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0228773 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0225639 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0223796 |
| VGLL4 | vestigial-like family member 4 | -0.0222928 |
| SCGB2B2 | secretoglobin, family 2B, member 2 | -0.022037 |
| SMYD3 | SET and MYND domain containing 3 | -0.0219226 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.0219016 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0217783 |
| PFN1 | profilin 1 | -0.0217778 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0217578 |
| MYOF | myoferlin | -0.0216618 |
| VCL | vinculin | -0.0215076 |
| CENPP | centromere protein P | -0.0209657 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | -0.0204258 |
| NUCB2 | nucleobindin 2 | -0.0202397 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0201918 |
| ZBTB1 | zinc finger and BTB domain containing 1 | -0.0201774 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0199501 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0198746 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0197845 |
| ANLN | anillin, actin binding protein | -0.0196551 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0195895 |
| TUT4 | terminal uridylyl transferase 4 | -0.0195748 |
| IGF2 | insulin-like growth factor 2 | -0.0193442 |
| RPLP1 | ribosomal protein, large, P1 | -0.019286 |
| MSI2 | musashi RNA-binding protein 2 | -0.0191633 |
| DENND5B | DENN/MADD domain containing 5B | -0.0191458 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0190211 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0188276 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0187984 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0187208 |
| SYCP2 | synaptonemal complex protein 2 | -0.0186787 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0186411 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.018499 |
| LAMA5 | laminin, alpha 5 | -0.0184704 |
| MTPN | myotrophin | -0.0183271 |
| EFNA5 | ephrin-A5 | -0.0183265 |
| PCED1B | PC-esterase domain containing 1B | -0.018232 |
| SEPTIN7 | septin 7 | -0.0181376 |
| S100A6 | S100 calcium binding protein A6 | -0.018114 |
| CCNI | cyclin I | -0.0180361 |
| ATXN2 | ataxin 2 | -0.0179844 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.0179339 |
| ECT2 | epithelial cell transforming 2 | -0.0178916 |
| CDK14 | cyclin-dependent kinase 14 | -0.0178462 |
| FNIP1 | folliculin interacting protein 1 | -0.0177623 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0177595 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0177104 |
| WDR45B | WD repeat domain 45B | -0.0177058 |
| HMGB1 | high mobility group box 1 | -0.0176047 |
| RPS21 | ribosomal protein S21 | -0.0173278 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0172657 |
| DEK | DEK proto-oncogene | -0.0172076 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.017046 |
| USO1 | USO1 vesicle transport factor | -0.0170322 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0170296 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0168629 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0168581 |
| SCARB2 | scavenger receptor class B, member 2 | -0.016757 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0167437 |
| TPX2 | TPX2, microtubule-associated | -0.0167218 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0166853 |
| UBE3A | ubiquitin protein ligase E3A | -0.0166444 |
| SP4 | Sp4 transcription factor | -0.0166429 |
| TP53 | tumor protein p53 | -0.016579 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0164534 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0163331 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.0162835 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0162182 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0161839 |
| PRR11 | proline rich 11 | -0.0160833 |
| PRELID2 | PRELI domain containing 2 | -0.0160563 |
