Dabrafenib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dabrafenib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dabrafenib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.148059
EXT1 exostosin glycosyltransferase 1 0.108571
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.107826
ZSWIM6 zinc finger, SWIM-type containing 6 0.104341
CXCL8 chemokine (C-X-C motif) ligand 8 0.101043
FAT1 FAT atypical cadherin 1 0.0881849
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0874425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0852807
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0844743
APLP2 amyloid beta (A4) precursor-like protein 2 0.0828402
AKAP12 A kinase (PRKA) anchor protein 12 0.0815078
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0793044
MCL1 myeloid cell leukemia 1 0.0781944
LOXL2 lysyl oxidase-like 2 0.0759875
EREG epiregulin 0.0734423
VIM vimentin 0.0725445
GRB10 growth factor receptor-bound protein 10 0.0671419
SMAD3 SMAD family member 3 0.0635349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.061802
FLNA filamin A, alpha 0.060969
NDRG1 N-myc downstream regulated 1 0.0605445
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0603059
MYH9 myosin, heavy chain 9, non-muscle 0.0592238
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0587555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0567296
ERRFI1 ERBB receptor feedback inhibitor 1 0.0566381
MACF1 microtubule-actin crosslinking factor 1 0.0550366
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0541239
SEPTIN9 septin 9 0.0538543
FN1 fibronectin 1 0.0525883
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.051068
PLEC plectin 0.0507234
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0497446
FNDC3B fibronectin type III domain containing 3B 0.0460298
EMP1 epithelial membrane protein 1 0.0455699
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0455448
RPL19 ribosomal protein L19 0.0451657
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0450614
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0448953
TFPI2 tissue factor pathway inhibitor 2 0.0443612
SOX9 SRY (sex determining region Y)-box 9 0.0443473
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0440598
PDIA4 protein disulfide isomerase family A, member 4 0.0439376
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0430244
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0429587
DUSP6 dual specificity phosphatase 6 0.0427521
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0423167
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0420059
CLIP2 CAP-GLY domain containing linker protein 2 0.0416838
TOP1 topoisomerase (DNA) I 0.0413179
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0409681
ACTN4 actinin, alpha 4 0.0403583
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0402358
SVIL supervillin 0.040212
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0401553
FAM13A family with sequence similarity 13, member A 0.0393702
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0387933
SHB Src homology 2 domain containing adaptor protein B 0.0384648
AGO2 argonaute RISC catalytic component 2 0.0381902
WWTR1 WW domain containing transcription regulator 1 0.037887
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0377751
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0375858
TPM3 tropomyosin 3 0.0368628
SOD2 superoxide dismutase 2, mitochondrial 0.0367738
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0358454
SFTPA2 surfactant protein A2 0.0350798
HSPA8 heat shock 70kDa protein 8 0.0345593
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0345051
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0338681
SIK3 SIK family kinase 3 0.033756
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0326748
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0326533
PRRC2C proline-rich coiled-coil 2C 0.0325742
FAM107B family with sequence similarity 107, member B 0.0314809
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0306717
ATXN1 ataxin 1 0.0302623
PCBP2 poly(rC) binding protein 2 0.0302261
GPATCH2L G patch domain containing 2-like 0.0302122
SGMS2 sphingomyelin synthase 2 0.0300814
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0299386
JARID2 jumonji, AT rich interactive domain 2 0.0297438
CTBP2 C-terminal binding protein 2 0.02972
PALM2AKAP2 PALM2 and AKAP2 fusion 0.029162
AREG amphiregulin 0.0289847
CSNK1A1 casein kinase 1, alpha 1 0.0289745
CALR calreticulin 0.0288016
RCOR1 REST corepressor 1 0.028481
ANXA5 annexin A5 0.0284298
ELL2 elongation factor, RNA polymerase II, 2 0.028222
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0279923
UBASH3B ubiquitin associated and SH3 domain containing B 0.0277295
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0275721
ANO6 anoctamin 6 0.0266691
RICTOR RPTOR independent companion of MTOR, complex 2 0.0266659
MBNL1 muscleblind-like splicing regulator 1 0.0265325
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0264619
PICALM phosphatidylinositol binding clathrin assembly protein 0.0263568
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0263547
MYO10 myosin X 0.026329
PTK2 protein tyrosine kinase 2 0.0263107

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.30963
NRG1 neuregulin 1 -0.19747
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.187689
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0933246
SQSTM1 sequestosome 1 -0.0896219
HLA-B major histocompatibility complex, class I, B -0.0741288
PTMA prothymosin, alpha -0.0731497
FTL ferritin, light polypeptide -0.0638809
SYT1 synaptotagmin I -0.0611848
TMSB10 thymosin beta 10 -0.0591313
IFI27 interferon, alpha-inducible protein 27 -0.0583193
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0561798
SOS1 son of sevenless homolog 1 (Drosophila) -0.0535272
SOX4 SRY (sex determining region Y)-box 4 -0.0504207
ITGA1 integrin, alpha 1 -0.0491404
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0483971
OSMR oncostatin M receptor -0.046839
MRPS6 mitochondrial ribosomal protein S6 -0.0458044
RPL35A ribosomal protein L35a -0.0455599
FTH1 ferritin, heavy polypeptide 1 -0.0445438
KLHL5 kelch-like family member 5 -0.0439181
S100A6 S100 calcium binding protein A6 -0.0434311
HMGA2 high mobility group AT-hook 2 -0.0425662
RPS6 ribosomal protein S6 -0.0403115
TMEM165 transmembrane protein 165 -0.0399372
ZMYND8 zinc finger, MYND-type containing 8 -0.038079
LOC102724023 ES1 protein homolog, mitochondrial -0.0372208
DNAH5 dynein, axonemal, heavy chain 5 -0.0371843
TPT1 tumor protein, translationally-controlled 1 -0.0370517
TMEM156 transmembrane protein 156 -0.0366878
TAS2R14 taste receptor, type 2, member 14 -0.0366115
ETV1 ets variant 1 -0.0362342
TNS3 tensin 3 -0.0360723
ACTG1 actin gamma 1 -0.0359588
AOPEP aminopeptidase O (putative) -0.035523
POTEF POTE ankyrin domain family, member F -0.0336433
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0328349
CENPF centromere protein F, 350/400kDa -0.0321045
PLIN2 perilipin 2 -0.0318736
MBD5 methyl-CpG binding domain protein 5 -0.0316194
RUNX2 runt-related transcription factor 2 -0.0315298
WSB1 WD repeat and SOCS box containing 1 -0.0313278
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0307143
LIMCH1 LIM and calponin homology domains 1 -0.030482
NPEPPS aminopeptidase puromycin sensitive -0.0296794
ETV6 ets variant 6 -0.0294631
GLUL glutamate-ammonia ligase -0.028248
EFNA5 ephrin-A5 -0.0281699
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0281572
TGFA transforming growth factor, alpha -0.0278463
IFI16 interferon, gamma-inducible protein 16 -0.0278411
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0278199
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0273277
CTSD cathepsin D -0.0271719
LRP5 low density lipoprotein receptor-related protein 5 -0.0271379
DPYD dihydropyrimidine dehydrogenase -0.0270158
IER3 immediate early response 3 -0.0268426
CD109 CD109 molecule -0.0268176
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0265627
LY6E lymphocyte antigen 6 complex, locus E -0.0261509
RTN4 reticulon 4 -0.0259096
FAM20C family with sequence similarity 20, member C -0.0253247
TGFB2 transforming growth factor, beta 2 -0.0248499
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0248255
TENM4 teneurin transmembrane protein 4 -0.0246801
GLIS3 GLIS family zinc finger 3 -0.0245487
NPC1 Niemann-Pick disease, type C1 -0.0239629
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0238522
RPL38 ribosomal protein L38 -0.0237274
NAMPT nicotinamide phosphoribosyltransferase -0.0236577
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.023599
RPS21 ribosomal protein S21 -0.0234034
RBM25 RNA binding motif protein 25 -0.0229418
ZBTB20 zinc finger and BTB domain containing 20 -0.0228944
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0228789
GNAS GNAS complex locus -0.0228605
KPNB1 karyopherin (importin) beta 1 -0.0215386
ANKRD12 ankyrin repeat domain 12 -0.0214078
RBM47 RNA binding motif protein 47 -0.0211445
IL6 interleukin 6 -0.0210553
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.020932
S100A9 S100 calcium binding protein A9 -0.0208386
BABAM2 BRISC and BRCA1 A complex member 2 -0.0208366
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.020232
LRMDA leucine rich melanocyte differentiation associated -0.0201954
LCORL ligand dependent nuclear receptor corepressor-like -0.0198026
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0197756
CP ceruloplasmin (ferroxidase) -0.0194821
SMOX spermine oxidase -0.0193399
UGCG UDP-glucose ceramide glucosyltransferase -0.0191958
RANBP17 RAN binding protein 17 -0.0191067
PNISR PNN-interacting serine/arginine-rich protein -0.0190665
NT5C2 5'-nucleotidase, cytosolic II -0.0190536
KRT81 keratin 81, type II -0.0190113
SKAP2 src kinase associated phosphoprotein 2 -0.0187647
STC2 stanniocalcin 2 -0.0185997
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0185866
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0185633
MKI67 marker of proliferation Ki-67 -0.0184883
RPL34 ribosomal protein L34 -0.0183734