Daidzin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.312091
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.226797
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.184799
IGFBP3 insulin-like growth factor binding protein 3 0.127451
VIM vimentin 0.0866426
COL8A1 collagen, type VIII, alpha 1 0.0751724
TRIO trio Rho guanine nucleotide exchange factor 0.0743614
DLG1 discs, large homolog 1 (Drosophila) 0.0608697
VEGFA vascular endothelial growth factor A 0.0551103
TPM3 tropomyosin 3 0.0530555
NFE2L1 nuclear factor, erythroid 2-like 1 0.0522024
PSD3 pleckstrin and Sec7 domain containing 3 0.0521287
LOXL2 lysyl oxidase-like 2 0.0516301
BHLHE40 basic helix-loop-helix family, member e40 0.0514728
NDRG1 N-myc downstream regulated 1 0.0507833
B2M beta-2-microglobulin 0.0476023
ELL2 elongation factor, RNA polymerase II, 2 0.0460931
DST dystonin 0.0443685
CD109 CD109 molecule 0.0400199
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0383143
SFTPA2 surfactant protein A2 0.0382797
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0376354
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0339069
MYADM myeloid-associated differentiation marker 0.033826
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0330749
C1D C1D nuclear receptor corepressor 0.0330231
ADAM17 ADAM metallopeptidase domain 17 0.0313277
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0311619
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0308689
OPTN optineurin 0.0306347
TNIP1 TNFAIP3 interacting protein 1 0.030599
SLC22A23 solute carrier family 22, member 23 0.030348
EZR ezrin 0.0299293
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0297684
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0297394
COL1A2 collagen, type I, alpha 2 0.028063
IQGAP1 IQ motif containing GTPase activating protein 1 0.0267947
ARRDC3 arrestin domain containing 3 0.0265572
FNIP1 folliculin interacting protein 1 0.0264954
MYH9 myosin, heavy chain 9, non-muscle 0.0262226
APP amyloid beta (A4) precursor protein 0.0260719
ARL15 ADP-ribosylation factor-like 15 0.0258309
FLNB filamin B, beta 0.0254332
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0248515
RTN4 reticulon 4 0.0245662
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0241904
KMT2E lysine (K)-specific methyltransferase 2E 0.0240385
ENO2 enolase 2 (gamma, neuronal) 0.0237322
GOLGA4 golgin A4 0.0234986
ATP13A3 ATPase type 13A3 0.0226603
TMSB10 thymosin beta 10 0.0217421
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0215826
COL4A1 collagen, type IV, alpha 1 0.0211865
SDC4 syndecan 4 0.0211471
COL7A1 collagen, type VII, alpha 1 0.0207115
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0206588
KIF16B kinesin family member 16B 0.0204894
HLA-A major histocompatibility complex, class I, A 0.0203848
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0203764
ZBTB7C zinc finger and BTB domain containing 7C 0.0203568
RPS6 ribosomal protein S6 0.0203054
CALR calreticulin 0.0201935
AXL AXL receptor tyrosine kinase 0.0195132
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0193228
AKAP9 A kinase (PRKA) anchor protein 9 0.0192563
SKIC3 SKI3 subunit of superkiller complex 0.0191234
WDFY1 WD repeat and FYVE domain containing 1 0.0191067
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0189676
RPS12 ribosomal protein S12 0.0189348
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0188823
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0186835
MTCL1 microtubule crosslinking factor 1 0.0185563
FAM13A family with sequence similarity 13, member A 0.0184552
ZEB2 zinc finger E-box binding homeobox 2 0.0183334
LINGO2 leucine rich repeat and Ig domain containing 2 0.017862
EEF1G eukaryotic translation elongation factor 1 gamma 0.0178481
ZFP36L1 ZFP36 ring finger protein-like 1 0.0175669
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.0174953
SPIRE1 spire-type actin nucleation factor 1 0.0174342
NCOR2 nuclear receptor corepressor 2 0.0171505
ANO6 anoctamin 6 0.0169647
ZNF160 zinc finger protein 160 0.016955
CD99 CD99 molecule 0.0169262
MSN moesin 0.0168215
VEGFC vascular endothelial growth factor C 0.0167966
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.01675
TNNT1 troponin T type 1 (skeletal, slow) 0.016748
SYTL3 synaptotagmin-like 3 0.0166698
SLC39A11 solute carrier family 39, member 11 0.0165608
CCDC88A coiled-coil domain containing 88A 0.0164089
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0163463
FRMD4A FERM domain containing 4A 0.016277
TMF1 TATA element modulatory factor 1 0.0162139
CLU clusterin 0.0161964
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0161459
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0160707
PLAUR plasminogen activator, urokinase receptor 0.0159591
RAI1 retinoic acid induced 1 0.0159146
SHB Src homology 2 domain containing adaptor protein B 0.0158728
YBX1 Y box binding protein 1 0.0157556

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.329451
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212232
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.127668
FSTL1 follistatin-like 1 -0.0933107
CANX calnexin -0.0904093
CDH13 cadherin 13 -0.0810628
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0723938
RIGI RNA sensor RIG-I -0.0707125
CCND1 cyclin D1 -0.0583666
FNDC3B fibronectin type III domain containing 3B -0.0574532
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0542927
COL5A2 collagen, type V, alpha 2 -0.0531776
ABI3BP ABI family, member 3 (NESH) binding protein -0.0531727
AHNAK AHNAK nucleoprotein -0.0518687
MAP1B microtubule-associated protein 1B -0.051846
MEIS2 Meis homeobox 2 -0.0483639
POTEF POTE ankyrin domain family, member F -0.0480686
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0455159
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0444931
FN1 fibronectin 1 -0.0441043
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0439526
TPT1 tumor protein, translationally-controlled 1 -0.0438427
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0426959
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0410915
VDAC1 voltage-dependent anion channel 1 -0.0410523
LOC112694756 uncharaterized LOC112694756 -0.0407999
NAP1L1 nucleosome assembly protein 1-like 1 -0.0400551
MBNL1 muscleblind-like splicing regulator 1 -0.039584
LOX lysyl oxidase -0.039555
SAMD9 sterile alpha motif domain containing 9 -0.0392329
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0381555
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0377883
S100A10 S100 calcium binding protein A10 -0.0377196
SLC38A1 solute carrier family 38, member 1 -0.0377018
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0373111
SP100 SP100 nuclear antigen -0.0370811
RNF213 ring finger protein 213 -0.0366314
FBN1 fibrillin 1 -0.0365338
ARF1 ADP-ribosylation factor 1 -0.0364276
ACTG1 actin gamma 1 -0.0356879
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0349274
CSTB cystatin B (stefin B) -0.0345681
IFI16 interferon, gamma-inducible protein 16 -0.0338618
IARS1 isoleucyl-tRNA synthetase 1 -0.0338205
RUNX1 runt-related transcription factor 1 -0.0333857
ZFAND3 zinc finger, AN1-type domain 3 -0.0331398
RPS24 ribosomal protein S24 -0.0328447
SQSTM1 sequestosome 1 -0.0327179
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0324752
AFF4 AF4/FMR2 family, member 4 -0.0321158
ZNF207 zinc finger protein 207 -0.0320361
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0320207
FLNA filamin A, alpha -0.0316885
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0314652
CDK6 cyclin-dependent kinase 6 -0.031255
CD44 CD44 molecule (Indian blood group) -0.03109
SDK1 sidekick cell adhesion molecule 1 -0.0306774
TUBB tubulin, beta class I -0.0304755
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0302795
RNF216 ring finger protein 216 -0.0298386
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0297422
PARD3 par-3 family cell polarity regulator -0.029515
PTK2 protein tyrosine kinase 2 -0.0294173
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0291749
ANKRD10 ankyrin repeat domain 10 -0.0285744
PDIA3 protein disulfide isomerase family A, member 3 -0.0285582
LDHA lactate dehydrogenase A -0.0284963
PICALM phosphatidylinositol binding clathrin assembly protein -0.0284756
TAOK1 TAO kinase 1 -0.0284473
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0284019
ZNF217 zinc finger protein 217 -0.0283952
SUCNR1 succinate receptor 1 -0.0282296
SEPTIN7 septin 7 -0.028026
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0279658
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0279234
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0277768
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0277196
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0275863
FBXL17 F-box and leucine-rich repeat protein 17 -0.0271083
EFNA5 ephrin-A5 -0.0269983
RAB7A RAB7A, member RAS oncogene family -0.0269263
ADAR adenosine deaminase, RNA-specific -0.0268869
NIPBL Nipped-B homolog (Drosophila) -0.0267933
THBS2 thrombospondin 2 -0.026771
UBC ubiquitin C -0.0267108
RHOBTB3 Rho-related BTB domain containing 3 -0.0266601
NT5C2 5'-nucleotidase, cytosolic II -0.0266157
ALCAM activated leukocyte cell adhesion molecule -0.0263798
FBXL7 F-box and leucine-rich repeat protein 7 -0.0263792
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0263448
IFIH1 interferon induced with helicase C domain 1 -0.0262887
PCDH7 protocadherin 7 -0.0262027
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0261224
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0260708
STAU1 staufen double-stranded RNA binding protein 1 -0.0259003
IPO9 importin 9 -0.0257975
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0257968
CLTC clathrin, heavy chain (Hc) -0.025727
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0255317
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0251557