Daidzin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.145651
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.10541
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.078499
MKI67 marker of proliferation Ki-67 0.0754001
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0750603
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0749633
PTMA prothymosin, alpha 0.070936
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0689074
SMC4 structural maintenance of chromosomes 4 0.0675337
EIF4B eukaryotic translation initiation factor 4B 0.0597803
TPI1 triosephosphate isomerase 1 0.0581873
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.056064
RRM2 ribonucleotide reductase M2 0.0512954
ACTG1 actin gamma 1 0.0503151
ANXA1 annexin A1 0.0484015
CENPF centromere protein F, 350/400kDa 0.0457948
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0443663
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0419533
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0386026
KIF18B kinesin family member 18B 0.0379148
AKAP12 A kinase (PRKA) anchor protein 12 0.0370085
ENO1 enolase 1, (alpha) 0.0356109
NHSL1 NHS-like 1 0.0343653
YBX1 Y box binding protein 1 0.0338726
RPS6 ribosomal protein S6 0.0334246
YAP1 Yes-associated protein 1 0.0322095
PFN1 profilin 1 0.0318829
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.031636
PDGFC platelet derived growth factor C 0.0312429
WDPCP WD repeat containing planar cell polarity effector 0.0310493
EEF1G eukaryotic translation elongation factor 1 gamma 0.0307754
PRELID2 PRELI domain containing 2 0.0307287
TRA2B transformer 2 beta homolog (Drosophila) 0.0306987
WWOX WW domain containing oxidoreductase 0.0306896
DST dystonin 0.0296239
ARRDC3 arrestin domain containing 3 0.0295131
RPS21 ribosomal protein S21 0.0293199
HDGF hepatoma-derived growth factor 0.0292606
DIAPH3 diaphanous-related formin 3 0.0276135
RPS19 ribosomal protein S19 0.0274981
ECT2 epithelial cell transforming 2 0.0269426
HSPA8 heat shock 70kDa protein 8 0.0269069
TPM3 tropomyosin 3 0.0268394
LDHA lactate dehydrogenase A 0.0266638
TPX2 TPX2, microtubule-associated 0.0259647
LDHB lactate dehydrogenase B 0.0258021
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0257422
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0255559
INCENP inner centromere protein antigens 135/155kDa 0.0254825
LRMDA leucine rich melanocyte differentiation associated 0.0253509
FAT1 FAT atypical cadherin 1 0.0252563
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0250874
RBM25 RNA binding motif protein 25 0.0246423
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0245459
MIS18BP1 MIS18 binding protein 1 0.0244196
SMC1A structural maintenance of chromosomes 1A 0.0242596
RACGAP1 Rac GTPase activating protein 1 0.0239274
HLA-A major histocompatibility complex, class I, A 0.0235292
S100A10 S100 calcium binding protein A10 0.0231292
PRDX1 peroxiredoxin 1 0.0230399
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0229512
TUBA1B tubulin, alpha 1b 0.0226453
RPS3 ribosomal protein S3 0.0225915
FUS FUS RNA binding protein 0.0225032
PABPN1 poly(A) binding protein, nuclear 1 0.021467
MATR3 matrin 3 0.021455
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0213369
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0211747
KRT18 keratin 18, type I 0.0211283
TPM4 tropomyosin 4 0.0210814
NDC80 NDC80 kinetochore complex component 0.0210764
PCDH9 protocadherin 9 0.021048
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0210053
TPT1 tumor protein, translationally-controlled 1 0.0207221
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0206636
RAD51B RAD51 paralog B 0.0204008
KIF4A kinesin family member 4A 0.0203261
TUBA1C tubulin, alpha 1c 0.0202302
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0201874
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0199253
RPS26 ribosomal protein S26 0.0198835
EPHA6 EPH receptor A6 0.0198783
SRRM2 serine/arginine repetitive matrix 2 0.0197493
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0195313
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0195027
PA2G4 proliferation-associated 2G4, 38kDa 0.01949
RPS4X ribosomal protein S4, X-linked 0.0194104
TMEM41B transmembrane protein 41B 0.0193591
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.019138
STMN1 stathmin 1 0.0190343
MYH9 myosin, heavy chain 9, non-muscle 0.0186866
SFPQ splicing factor proline/glutamine-rich 0.0185733
CBX3 chromobox homolog 3 0.0185335
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0184519
UNC13A unc-13 homolog A (C. elegans) 0.0182391
FTH1 ferritin, heavy polypeptide 1 0.0181621
CKAP5 cytoskeleton associated protein 5 0.0181543
SPAG5 sperm associated antigen 5 0.0181377
RPS8 ribosomal protein S8 0.0180465
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0180142

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.207094
MMP12 matrix metallopeptidase 12 -0.152587
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.127647
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.104917
SLC38A2 solute carrier family 38, member 2 -0.0984224
ZBTB20 zinc finger and BTB domain containing 20 -0.0892032
DPYD dihydropyrimidine dehydrogenase -0.0883005
TXNRD1 thioredoxin reductase 1 -0.0854863
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0779937
PCDH7 protocadherin 7 -0.074268
CELF2 CUGBP, Elav-like family member 2 -0.0683078
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0654315
PDE4D phosphodiesterase 4D, cAMP-specific -0.0624518
EXOC6B exocyst complex component 6B -0.0618577
VIM vimentin -0.061029
CLDN1 claudin 1 -0.0607932
AREG amphiregulin -0.0571369
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0571257
ZNF804A zinc finger protein 804A -0.0568727
FTL ferritin, light polypeptide -0.0556714
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0546639
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532882
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0494652
ADGRG6 adhesion G protein-coupled receptor G6 -0.0491938
FBXO11 F-box protein 11 -0.048441
TSC22D2 TSC22 domain family, member 2 -0.0475848
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0473936
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0458989
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458475
NIPBL Nipped-B homolog (Drosophila) -0.0448745
RPS2 ribosomal protein S2 -0.04453
NABP1 nucleic acid binding protein 1 -0.043366
CXADR coxsackie virus and adenovirus receptor -0.0426199
USP34 ubiquitin specific peptidase 34 -0.0425005
HMGA2 high mobility group AT-hook 2 -0.0421604
ZFAND3 zinc finger, AN1-type domain 3 -0.0421586
AHNAK AHNAK nucleoprotein -0.0406748
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0404791
RAB1A RAB1A, member RAS oncogene family -0.0403676
RASAL2 RAS protein activator like 2 -0.0401743
RAB10 RAB10, member RAS oncogene family -0.040132
DLC1 DLC1 Rho GTPase activating protein -0.0399178
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0397581
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0390466
EIF1 eukaryotic translation initiation factor 1 -0.0387447
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0387442
SPAG9 sperm associated antigen 9 -0.0387401
RNF13 ring finger protein 13 -0.0384777
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0379341
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0370888
CLTC clathrin, heavy chain (Hc) -0.036288
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0362675
AFF4 AF4/FMR2 family, member 4 -0.0362482
BIRC3 baculoviral IAP repeat containing 3 -0.0360911
TMEM131 transmembrane protein 131 -0.0359079
CARD16 caspase recruitment domain family, member 16 -0.0357394
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0352633
FBXL20 F-box and leucine-rich repeat protein 20 -0.0350332
ELP4 elongator acetyltransferase complex subunit 4 -0.0343796
LMO7 LIM domain 7 -0.0340959
CCND1 cyclin D1 -0.0334951
CAMKMT calmodulin-lysine N-methyltransferase -0.0334059
WASF2 WAS protein family, member 2 -0.0332058
IL6ST interleukin 6 signal transducer -0.03305
ERBIN erbb2 interacting protein -0.0329841
ZNF638 zinc finger protein 638 -0.032442
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0324373
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0317579
BCHE butyrylcholinesterase -0.0316779
BIRC6 baculoviral IAP repeat containing 6 -0.0314321
ARB2A ARB2 cotranscriptional regulator A -0.0311835
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0309226
NCOR1 nuclear receptor corepressor 1 -0.0308507
EDN1 endothelin 1 -0.0307567
NF1 neurofibromin 1 -0.0305368
VDAC1 voltage-dependent anion channel 1 -0.0302208
BCAS3 breast carcinoma amplified sequence 3 -0.0301317
PDCD10 programmed cell death 10 -0.0300606
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0300405
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0298032
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0296005
XPO1 exportin 1 -0.0295942
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0295737
CANX calnexin -0.0293325
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0289886
RABGAP1L RAB GTPase activating protein 1-like -0.0289336
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.02856
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0283698
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0282116
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0281509
BIRC2 baculoviral IAP repeat containing 2 -0.0277795
CPNE1 copine I -0.0276043
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.027593
SEC62 SEC62 homolog (S. cerevisiae) -0.0275889
RAD21 RAD21 homolog (S. pombe) -0.0273845
LMAN1 lectin, mannose-binding, 1 -0.0273303
USP15 ubiquitin specific peptidase 15 -0.0272817
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0272603
EGFR epidermal growth factor receptor -0.0271723
RTN3 reticulon 3 -0.0270189