Daidzin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.138687
VEGFA vascular endothelial growth factor A 0.127646
CDH10 cadherin 10, type 2 (T2-cadherin) 0.109286
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.107195
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0998983
DST dystonin 0.0755083
LSAMP limbic system-associated membrane protein 0.0732462
MEIS2 Meis homeobox 2 0.0697523
NDRG1 N-myc downstream regulated 1 0.0688939
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0665197
MSI2 musashi RNA-binding protein 2 0.0617462
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0587205
AKAP12 A kinase (PRKA) anchor protein 12 0.0573448
PTPRD protein tyrosine phosphatase, receptor type, D 0.0523846
SEPTIN9 septin 9 0.0522565
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.048423
CD36 CD36 molecule (thrombospondin receptor) 0.0463915
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0454636
RAD51B RAD51 paralog B 0.0429371
ZMIZ1 zinc finger, MIZ-type containing 1 0.0425376
DPH6 diphthamine biosynthesis 6 0.0421112
SLITRK6 SLIT and NTRK-like family, member 6 0.0405198
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.040438
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0397896
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.039458
CENPF centromere protein F, 350/400kDa 0.0387627
IGF2 insulin-like growth factor 2 0.0387146
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0369047
EIF4B eukaryotic translation initiation factor 4B 0.0355798
NCOR2 nuclear receptor corepressor 2 0.0349061
SSBP3 single stranded DNA binding protein 3 0.034415
HELZ helicase with zinc finger 0.0337512
FNBP1 formin binding protein 1 0.0335854
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0316687
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0316608
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0313355
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030822
MACF1 microtubule-actin crosslinking factor 1 0.0307917
CASC3 cancer susceptibility candidate 3 0.0303526
DDIT4 DNA-damage-inducible transcript 4 0.0301479
ERRFI1 ERBB receptor feedback inhibitor 1 0.0295434
TRIB2 tribbles pseudokinase 2 0.029209
SOX9 SRY (sex determining region Y)-box 9 0.0289153
ASPH aspartate beta-hydroxylase 0.0284143
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0281582
ZCCHC7 zinc finger, CCHC domain containing 7 0.0278503
MYH9 myosin, heavy chain 9, non-muscle 0.0277719
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0271471
UBA6 ubiquitin-like modifier activating enzyme 6 0.0267561
NREP neuronal regeneration related protein 0.0266656
PDE8A phosphodiesterase 8A 0.0261183
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0260101
BCLAF1 BCL2-associated transcription factor 1 0.0259939
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0259443
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0254511
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0253176
EEF2 eukaryotic translation elongation factor 2 0.0251989
HILPDA hypoxia inducible lipid droplet-associated 0.0249987
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0249071
MAML2 mastermind-like 2 (Drosophila) 0.0249068
LPIN1 lipin 1 0.024905
ARRDC3 arrestin domain containing 3 0.0248961
YEATS2 YEATS domain containing 2 0.0243489
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0242441
LAMA5 laminin, alpha 5 0.0235726
SMAD3 SMAD family member 3 0.0235716
RNF150 ring finger protein 150 0.0232521
ZNF395 zinc finger protein 395 0.0231853
CDK19 cyclin-dependent kinase 19 0.0231309
SH3RF1 SH3 domain containing ring finger 1 0.0231148
NRIP1 nuclear receptor interacting protein 1 0.0230635
TCF12 transcription factor 12 0.0229548
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0228897
PRRC2C proline-rich coiled-coil 2C 0.0228466
GOLGA4 golgin A4 0.0226618
FLNB filamin B, beta 0.02256
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0224673
KDM4C lysine (K)-specific demethylase 4C 0.0223758
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0220599
FDXR ferredoxin reductase 0.0219772
ATXN1 ataxin 1 0.0219449
CEP250 centrosomal protein 250kDa 0.0219171
CADM2 cell adhesion molecule 2 0.0216759
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0215329
ANGPT1 angiopoietin 1 0.0214834
ARHGAP9 Rho GTPase activating protein 9 0.0213788
MATR3 matrin 3 0.0213003
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0212507
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0211035
ZNF148 zinc finger protein 148 0.0208178
ZFP36 ZFP36 ring finger protein 0.0208102
HSPA8 heat shock 70kDa protein 8 0.0206347
FRMD6 FERM domain containing 6 0.0205792
ZNF292 zinc finger protein 292 0.0205204
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0205053
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0203031
ANKRD36 ankyrin repeat domain 36 0.0202403
MEF2A myocyte enhancer factor 2A 0.0202244
DACH2 dachshund family transcription factor 2 0.0202172
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0201063

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.350851
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176136
VCL vinculin -0.106821
FMN1 formin 1 -0.099119
SYT1 synaptotagmin I -0.0989895
EXT1 exostosin glycosyltransferase 1 -0.0985497
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0924679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0857129
NRG1 neuregulin 1 -0.0828185
TPST1 tyrosylprotein sulfotransferase 1 -0.0771661
EIF1 eukaryotic translation initiation factor 1 -0.0653286
ACTG1 actin gamma 1 -0.0606577
TLE4 transducin-like enhancer of split 4 -0.05919
VIM vimentin -0.0569312
RPL19 ribosomal protein L19 -0.0567505
ZFAND3 zinc finger, AN1-type domain 3 -0.056506
PLAT plasminogen activator, tissue -0.0564045
SIK2 salt-inducible kinase 2 -0.0560996
RPS24 ribosomal protein S24 -0.0551713
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0550779
RPLP1 ribosomal protein, large, P1 -0.0523782
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0520441
TPM1 tropomyosin 1 (alpha) -0.0507882
TPT1 tumor protein, translationally-controlled 1 -0.0506322
FRMD4A FERM domain containing 4A -0.0503533
RPL38 ribosomal protein L38 -0.0481531
FNDC3A fibronectin type III domain containing 3A -0.0478712
GLCCI1 glucocorticoid induced 1 -0.0478687
COL1A1 collagen, type I, alpha 1 -0.0459353
CEMIP cell migration inducing protein, hyaluronan binding -0.0459188
COL3A1 collagen, type III, alpha 1 -0.0459108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442433
PLPP1 phospholipid phosphatase 1 -0.0441572
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0433607
NCOA7 nuclear receptor coactivator 7 -0.0419958
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0415879
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0406043
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0404678
CANX calnexin -0.039914
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0397365
NPEPPS aminopeptidase puromycin sensitive -0.039658
RIGI RNA sensor RIG-I -0.0388666
H3-3B H3.3 histone B -0.0388608
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0388293
CLTC clathrin, heavy chain (Hc) -0.0385514
GPATCH8 G patch domain containing 8 -0.0379457
MAP1B microtubule-associated protein 1B -0.0375562
LOC112694756 uncharaterized LOC112694756 -0.0369181
GREM2 gremlin 2, DAN family BMP antagonist -0.0367006
B2M beta-2-microglobulin -0.0365719
KLHL13 kelch-like family member 13 -0.036507
ADGRG6 adhesion G protein-coupled receptor G6 -0.0364408
RPL35A ribosomal protein L35a -0.0360257
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0357168
ZC3H11A zinc finger CCCH-type containing 11A -0.0352275
PDIA3 protein disulfide isomerase family A, member 3 -0.0351308
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0349911
ZMYM2 zinc finger, MYM-type 2 -0.0340486
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0339558
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0338929
BPTF bromodomain PHD finger transcription factor -0.0335342
GNAS GNAS complex locus -0.0333408
CCND1 cyclin D1 -0.0327266
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0324633
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0322939
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0322475
SP100 SP100 nuclear antigen -0.031884
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0316365
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0309786
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0307035
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0304656
POGZ pogo transposable element with ZNF domain -0.030109
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0299848
HDLBP high density lipoprotein binding protein -0.0299568
SOD2 superoxide dismutase 2, mitochondrial -0.0298508
PTMA prothymosin, alpha -0.0297951
RHOBTB3 Rho-related BTB domain containing 3 -0.0297623
SPAG9 sperm associated antigen 9 -0.0294953
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0293234
ARHGAP5 Rho GTPase activating protein 5 -0.0292085
EGR1 early growth response 1 -0.0287207
DCAF7 DDB1 and CUL4 associated factor 7 -0.028699
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0286115
THBS1 thrombospondin 1 -0.0285798
NEK7 NIMA-related kinase 7 -0.0280186
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0279683
STC1 stanniocalcin 1 -0.0278728
SLIT2 slit homolog 2 (Drosophila) -0.0274388
GLG1 golgi glycoprotein 1 -0.0274289
PDE10A phosphodiesterase 10A -0.0268853
ELF2 E74-like factor 2 (ets domain transcription factor) -0.026873
RPS6 ribosomal protein S6 -0.0267503
LMAN1 lectin, mannose-binding, 1 -0.0267477
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0267126
TMSB10 thymosin beta 10 -0.0265743
STK38L serine/threonine kinase 38 like -0.0264941
FAM107B family with sequence similarity 107, member B -0.0263762
RPS14 ribosomal protein S14 -0.0263659
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0262637
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0261129