Daidzin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Daidzin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Daidzin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.124817
ZMYND8 zinc finger, MYND-type containing 8 0.108885
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0879302
FNDC3B fibronectin type III domain containing 3B 0.0774416
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0704285
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0650871
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0613381
EZR ezrin 0.0572416
GRK3 G protein-coupled receptor kinase 3 0.0566435
ARRDC3 arrestin domain containing 3 0.0562668
TRIO trio Rho guanine nucleotide exchange factor 0.0549737
VEGFA vascular endothelial growth factor A 0.0544874
TSC22D1 TSC22 domain family, member 1 0.0533832
BHLHE40 basic helix-loop-helix family, member e40 0.0531308
PTMA prothymosin, alpha 0.052784
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0527306
APOL1 apolipoprotein L, 1 0.052714
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0518507
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0515224
TMPRSS4 transmembrane protease, serine 4 0.0512068
HLA-B major histocompatibility complex, class I, B 0.0501684
SLC22A23 solute carrier family 22, member 23 0.0495072
H1-0 H1.0 linker histone 0.047608
AHNAK AHNAK nucleoprotein 0.0461778
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0458636
B2M beta-2-microglobulin 0.0455407
PLAUR plasminogen activator, urokinase receptor 0.0453503
JUN jun proto-oncogene 0.0445084
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0443994
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0443426
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0436781
NAMPT nicotinamide phosphoribosyltransferase 0.0429314
TXNIP thioredoxin interacting protein 0.0424452
SDC4 syndecan 4 0.0423637
KLF6 Kruppel-like factor 6 0.0419683
TM4SF1 transmembrane 4 L six family member 1 0.0418407
DST dystonin 0.0417072
GOLGA4 golgin A4 0.0415762
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0414461
SLK STE20-like kinase 0.0413729
ADM adrenomedullin 0.0408615
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0397297
ATXN1 ataxin 1 0.0396575
XAF1 XIAP associated factor 1 0.039535
ITGA6 integrin, alpha 6 0.0392574
ZNF292 zinc finger protein 292 0.0389126
MT2A metallothionein 2A 0.0388637
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0380128
TPT1 tumor protein, translationally-controlled 1 0.0377311
OGA O-GlcNAcase 0.0376186
KIF16B kinesin family member 16B 0.0376041
MT1X metallothionein 1X 0.0373057
CSTB cystatin B (stefin B) 0.0369711
ERBIN erbb2 interacting protein 0.0365063
RNF149 ring finger protein 149 0.036113
ALPK1 alpha-kinase 1 0.0360507
HLA-A major histocompatibility complex, class I, A 0.0351395
MLPH melanophilin 0.0345806
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0342306
FAM13A family with sequence similarity 13, member A 0.0341078
FN1 fibronectin 1 0.0337424
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0336577
MYH9 myosin, heavy chain 9, non-muscle 0.0333196
NPSR1 neuropeptide S receptor 1 0.0331935
SQSTM1 sequestosome 1 0.0322516
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0320453
ESYT2 extended synaptotagmin-like protein 2 0.0318143
SPATA13 spermatogenesis associated 13 0.0318122
HLA-E major histocompatibility complex, class I, E 0.0317721
STYXL2 serine/threonine/tyrosine interacting like 2 0.0317176
ARHGAP26 Rho GTPase activating protein 26 0.0316751
MACC1 metastasis associated in colon cancer 1 0.0314519
VIM vimentin 0.0313233
CMIP c-Maf inducing protein 0.031196
APP amyloid beta (A4) precursor protein 0.0307343
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0305705
ABHD17C abhydrolase domain containing 17C 0.030469
IGFBP3 insulin-like growth factor binding protein 3 0.0303786
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0300118
SERF2 small EDRK-rich factor 2 0.0298465
STS steroid sulfatase (microsomal), isozyme S 0.029689
ZNF395 zinc finger protein 395 0.0296192
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0292825
PADI1 peptidyl arginine deiminase, type I 0.0291854
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0291417
DDIT4 DNA-damage-inducible transcript 4 0.0290859
BACE2 beta-site APP-cleaving enzyme 2 0.0290665
MXI1 MAX interactor 1, dimerization protein 0.0288976
DYNC2I1 dynein 2 intermediate chain 1 0.0287123
YBX3 Y box binding protein 3 0.0286377
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0285783
PTPRF protein tyrosine phosphatase, receptor type, F 0.0282179
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0265745
JMJD1C jumonji domain containing 1C 0.0265307
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0264913
AKAP12 A kinase (PRKA) anchor protein 12 0.0264212
FNIP1 folliculin interacting protein 1 0.0261367
MUC20 mucin 20, cell surface associated 0.0260892
MTUS1 microtubule associated tumor suppressor 1 0.0260562
RPL37A ribosomal protein L37a 0.0259873

decreased expression

Symbol Name Standardized Value
PDIA3 protein disulfide isomerase family A, member 3 -0.11881
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117745
INTS6 integrator complex subunit 6 -0.116582
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103889
MAP7 microtubule-associated protein 7 -0.103398
LCN2 lipocalin 2 -0.0998687
EPSTI1 epithelial stromal interaction 1 (breast) -0.0984416
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.092221
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0830736
PKM pyruvate kinase, muscle -0.081477
RNF43 ring finger protein 43 -0.0780286
GCLC glutamate-cysteine ligase, catalytic subunit -0.0731919
PERP PERP, TP53 apoptosis effector -0.0720493
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0657386
NRIP1 nuclear receptor interacting protein 1 -0.0651261
AHI1 Abelson helper integration site 1 -0.0645178
FNDC3A fibronectin type III domain containing 3A -0.0636036
EPHB2 EPH receptor B2 -0.0627941
C6ORF132 chromosome 6 open reading frame 132 -0.0619082
IFNGR1 interferon gamma receptor 1 -0.0563208
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0560546
BTBD9 BTB (POZ) domain containing 9 -0.055189
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0538638
SP100 SP100 nuclear antigen -0.0538309
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0513357
RUNX1 runt-related transcription factor 1 -0.0498953
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0494102
ZMYM2 zinc finger, MYM-type 2 -0.049138
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0484831
PLSCR2 phospholipid scramblase 2 -0.0481479
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0471002
TM9SF2 transmembrane 9 superfamily member 2 -0.0460317
LOC112694756 uncharaterized LOC112694756 -0.0455781
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0443895
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0443309
PTBP3 polypyrimidine tract binding protein 3 -0.0435219
NF1 neurofibromin 1 -0.0431658
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0419152
PIBF1 progesterone immunomodulatory binding factor 1 -0.041833
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0408405
FOXP1 forkhead box P1 -0.0404023
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0391086
FAT1 FAT atypical cadherin 1 -0.0388352
FAF1 Fas (TNFRSF6) associated factor 1 -0.0385301
ADAR adenosine deaminase, RNA-specific -0.038525
MBNL1 muscleblind-like splicing regulator 1 -0.0384396
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0383403
TRERF1 transcriptional regulating factor 1 -0.0379497
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0376291
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0371303
POTEF POTE ankyrin domain family, member F -0.0370362
TTC3 tetratricopeptide repeat domain 3 -0.0368806
HBS1L HBS1-like translational GTPase -0.0360053
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0359892
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0357358
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0355293
RFC3 replication factor C (activator 1) 3, 38kDa -0.0350353
HDAC4 histone deacetylase 4 -0.0343678
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0338942
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0338345
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0336828
LYZ lysozyme -0.0336111
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0334922
IL20RA interleukin 20 receptor, alpha -0.0328947
SERINC5 serine incorporator 5 -0.0328369
YAP1 Yes-associated protein 1 -0.0326701
CSNK1A1 casein kinase 1, alpha 1 -0.0324295
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0320297
VWA8 von Willebrand factor A domain containing 8 -0.0320228
HM13 histocompatibility (minor) 13 -0.0313777
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0309058
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0305349
MEIS2 Meis homeobox 2 -0.030349
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0302473
RPLP1 ribosomal protein, large, P1 -0.0300916
EGR1 early growth response 1 -0.0300415
EFNB2 ephrin-B2 -0.029958
ACTG1 actin gamma 1 -0.0296417
RB1 retinoblastoma 1 -0.0296214
SETX senataxin -0.0295963
COG6 component of oligomeric golgi complex 6 -0.0291127
DIAPH3 diaphanous-related formin 3 -0.0290762
VMP1 vacuole membrane protein 1 -0.0290478
DIAPH1 diaphanous-related formin 1 -0.0289985
USP3 ubiquitin specific peptidase 3 -0.028332
ZNF207 zinc finger protein 207 -0.028238
BRD4 bromodomain containing 4 -0.0282254
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0279964
MRPS10 mitochondrial ribosomal protein S10 -0.0279713
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.027834
RAB7A RAB7A, member RAS oncogene family -0.0276907
RABGAP1L RAB GTPase activating protein 1-like -0.027585
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.027553
SENP5 SUMO1/sentrin specific peptidase 5 -0.0274861
METTL15 methyltransferase like 15 -0.0274189
ZNFX1 zinc finger, NFX1-type containing 1 -0.0268496
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.026697
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0266179
SGK1 serum/glucocorticoid regulated kinase 1 -0.0260124
STAU1 staufen double-stranded RNA binding protein 1 -0.0258224